Detailed information NTG0585186

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: KU530_RS13400
• Genome accession: NZ_CP077921
• Coordinates: 2723136..2724179 (+)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain 276
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2718136..2729179

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
KU530_RS13370 (KU530_13310)	-	2718503..2718613 (+)	111	WP_001790257.1	hypothetical protein	-
KU530_RS13375 (KU530_13315)	-	2718642..2719055 (+)	414	WP_001566709.1	hypothetical protein	-
KU530_RS13380 (KU530_13320)	-	2719545..2720531 (-)	987	WP_000999713.1	FUSC family protein	-
KU530_RS13385 (KU530_13325)	map	2721062..2721820 (+)	759	WP_000636142.1	type I methionyl aminopeptidase	-
KU530_RS13390 (KU530_13330)	-	2722037..2722423 (+)	387	WP_001110179.1	hypothetical protein	-
KU530_RS13395 (KU530_13335)	liaF	2722438..2723139 (+)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
KU530_RS13400 (KU530_13340)	vraS	2723136..2724179 (+)	1044	WP_001017131.1	sensor histidine kinase	Regulator
KU530_RS13405 (KU530_13345)	vraR	2724169..2724798 (+)	630	WP_000153536.1	two-component system response regulator VraR	Regulator
KU530_RS13410 (KU530_13350)	-	2724910..2726127 (-)	1218	WP_000037079.1	YihY/virulence factor BrkB family protein	-
KU530_RS13415 (KU530_13355)	-	2726405..2726680 (-)	276	WP_000428172.1	YtxH domain-containing protein	-
KU530_RS13420 (KU530_13360)	-	2726687..2727151 (-)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
KU530_RS13425 (KU530_13365)	-	2727298..2727498 (+)	201	WP_000180460.1	DUF1128 family protein	-
KU530_RS13430 (KU530_13370)	-	2727501..2728757 (+)	1257	WP_072419726.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=585186 KU530_RS13400 WP_001017131.1 2723136..2724179(+) (vraS) [Staphylococcus aureus strain 276]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=585186 KU530_RS13400 WP_001017131.1 2723136..2724179(+) (vraS) [Staphylococcus aureus strain 276]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTAATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGCATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCATACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAATTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTGGCTCGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGTTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCGATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1