Detailed information    

insolico Bioinformatically predicted

Overview

Name   agrA   Type   Regulator
Locus tag   KU530_RS12945 Genome accession   NZ_CP077921
Coordinates   2637491..2638207 (-) Length   238 a.a.
NCBI ID   WP_000688498.1    Uniprot ID   Q2VG52
Organism   Staphylococcus aureus strain 276     
Function   promote expression of competence genes (predicted from homology)   
Competence regulation

Genomic Context

Location: 2632491..2643207
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  KU530_RS12925 (KU530_12875) - 2633583..2634533 (+) 951 WP_000790329.1 LacI family DNA-binding transcriptional regulator -
  KU530_RS12930 (KU530_12880) - 2634682..2636166 (+) 1485 WP_000141411.1 sucrose-6-phosphate hydrolase -
  KU530_RS12935 (KU530_12885) - 2636163..2637122 (+) 960 WP_001253291.1 carbohydrate kinase family protein -
  KU530_RS12940 (KU530_12890) - 2637310..2637419 (-) 110 Protein_2512 hypothetical protein -
  KU530_RS12945 (KU530_12895) agrA 2637491..2638207 (-) 717 WP_000688498.1 quorum-sensing response regulator AgrA Regulator
  KU530_RS12950 (KU530_12900) agrC 2638226..2639509 (-) 1284 WP_047928561.1 quorum-sensing sensor histidine kinase AgrC -
  KU530_RS12955 (KU530_12905) agrD 2639539..2639682 (-) 144 WP_001094921.1 cyclic lactone autoinducer peptide AgrD -
  KU530_RS12960 (KU530_12910) - 2639685..2640248 (-) 564 WP_001105696.1 accessory gene regulator AgrB -
  KU530_RS13485 hld 2640538..2640618 (+) 81 WP_000046022.1 delta-hemolysin -
  KU530_RS12970 (KU530_12920) - 2641218..2642003 (-) 786 WP_000867950.1 carbon-nitrogen family hydrolase -
  KU530_RS12975 (KU530_12925) - 2642364..2642990 (-) 627 WP_225806585.1 nitroreductase family protein -

Sequence

Protein


Download         Length: 238 a.a.        Molecular weight: 27933.91 Da        Isoelectric Point: 6.0927

>NTDB_id=585185 KU530_RS12945 WP_000688498.1 2637491..2638207(-) (agrA) [Staphylococcus aureus strain 276]
MKIFICEDDPKQRENMVTIIKNYIMIEEKPMEIALATDNPYEVLEQAKNMNDIGCYFLDIQLSTDINGIKLGSEIRKHDP
VGNIIFVTSHSELTYLTFVYKVAAMDFIFKDDPAELRTRIIDCLETAHTRLQLLSRDNSVETIELKRGSNSVYVQYDDIM
FFESSTKSHRLIAHLDNRQIEFYGNLKELSQLDDRFFRCHNSFVVNRHNIESIDSKERIVYFKNKEHCYASVRNVKKI

Nucleotide


Download         Length: 717 bp        

>NTDB_id=585185 KU530_RS12945 WP_000688498.1 2637491..2638207(-) (agrA) [Staphylococcus aureus strain 276]
ATGAAAATTTTCATTTGCGAAGACGATCCAAAACAAAGAGAAAACATGGTTACCATTATTAAAAATTATATAATGATAGA
AGAAAAGCCTATGGAAATTGCCCTCGCAACTGATAATCCTTATGAGGTGCTTGAGCAAGCTAAAAATATGAATGACATAG
GCTGTTACTTTTTAGATATTCAACTTTCAACTGATATTAATGGTATCAAATTAGGCAGTGAAATTCGTAAGCATGACCCA
GTTGGTAACATTATTTTCGTTACGAGTCACAGTGAACTTACCTATTTAACATTTGTCTACAAAGTTGCAGCGATGGATTT
TATTTTTAAAGATGATCCAGCAGAATTAAGAACTCGAATTATAGATTGTTTAGAAACTGCACATACACGTTTACAATTAT
TATCAAGAGATAATAGCGTTGAAACGATTGAATTAAAACGTGGCAGTAATTCAGTGTATGTTCAATATGATGATATTATG
TTTTTTGAATCATCAACAAAATCTCACAGACTCATTGCCCATTTAGATAACCGTCAAATTGAATTTTATGGTAATTTAAA
AGAACTGAGTCAATTAGATGATCGTTTCTTTAGATGTCATAATAGCTTTGTCGTCAATCGCCATAATATTGAATCTATAG
ATTCGAAAGAGCGAATTGTCTATTTTAAAAATAAAGAACACTGCTATGCATCGGTGAGAAACGTTAAAAAAATATAA

Domains

Predicted by InterproScan.

LytTr DNA-binding domain (LytTR)

(151-237)

Response regulator receiver domain (Response_reg)

(3-120)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB Q2VG52

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  agrA Staphylococcus aureus N315

99.58

100

0.996