Detailed information NTG0585122

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: KU525_RS09945
• Genome accession: NZ_CP077920
• Coordinates: 2015975..2017018 (+)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain 277
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2010975..2022018

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
KU525_RS09915 (KU525_09955)	-	2011342..2011452 (+)	111	WP_001790257.1	hypothetical protein	-
KU525_RS09920 (KU525_09960)	-	2011481..2011894 (+)	414	WP_001670387.1	hypothetical protein	-
KU525_RS09925 (KU525_09965)	-	2012384..2013370 (-)	987	WP_000999716.1	FUSC family protein	-
KU525_RS09930 (KU525_09970)	map	2013901..2014659 (+)	759	WP_000636142.1	type I methionyl aminopeptidase	-
KU525_RS09935 (KU525_09975)	-	2014876..2015262 (+)	387	WP_001110179.1	hypothetical protein	-
KU525_RS09940 (KU525_09980)	liaF	2015277..2015978 (+)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
KU525_RS09945 (KU525_09985)	vraS	2015975..2017018 (+)	1044	WP_001017131.1	sensor histidine kinase	Regulator
KU525_RS09950 (KU525_09990)	vraR	2017008..2017637 (+)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
KU525_RS09955 (KU525_09995)	-	2017753..2018970 (-)	1218	WP_000037075.1	YihY/virulence factor BrkB family protein	-
KU525_RS09960 (KU525_10000)	-	2019248..2019523 (-)	276	WP_000428171.1	hypothetical protein	-
KU525_RS09965 (KU525_10005)	-	2019530..2019994 (-)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
KU525_RS09970 (KU525_10010)	-	2020141..2020341 (+)	201	WP_000180460.1	DUF1128 family protein	-
KU525_RS09975 (KU525_10015)	-	2020344..2021600 (+)	1257	WP_001789555.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=585122 KU525_RS09945 WP_001017131.1 2015975..2017018(+) (vraS) [Staphylococcus aureus strain 277]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=585122 KU525_RS09945 WP_001017131.1 2015975..2017018(+) (vraS) [Staphylococcus aureus strain 277]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTATTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCATACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAGTTGCATAAGTTGCGACTTAAAACTCAAAATTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTGGCTCGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTTTCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1