Detailed information NTG0585100

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: KU514_RS13210
• Genome accession: NZ_CP077919
• Coordinates: 2647653..2648696 (+)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain 278
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2642653..2653696

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
KU514_RS13180 (KU514_13095)	-	2643020..2643130 (+)	111	WP_001790257.1	hypothetical protein	-
KU514_RS13185 (KU514_13100)	-	2643159..2643572 (+)	414	WP_001566709.1	hypothetical protein	-
KU514_RS13190 (KU514_13105)	-	2644062..2645048 (-)	987	WP_000999713.1	aromatic acid exporter family protein	-
KU514_RS13195 (KU514_13110)	map	2645579..2646337 (+)	759	WP_000636142.1	type I methionyl aminopeptidase	-
KU514_RS13200 (KU514_13115)	-	2646554..2646940 (+)	387	WP_001110179.1	hypothetical protein	-
KU514_RS13205 (KU514_13120)	liaF	2646955..2647656 (+)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
KU514_RS13210 (KU514_13125)	vraS	2647653..2648696 (+)	1044	WP_001017131.1	sensor histidine kinase	Regulator
KU514_RS13215 (KU514_13130)	vraR	2648686..2649315 (+)	630	WP_000153536.1	two-component system response regulator VraR	Regulator
KU514_RS13220 (KU514_13135)	-	2649427..2650644 (-)	1218	WP_000037079.1	YihY/virulence factor BrkB family protein	-
KU514_RS13225 (KU514_13140)	-	2650922..2651197 (-)	276	WP_000428172.1	YtxH domain-containing protein	-
KU514_RS13230 (KU514_13145)	-	2651204..2651668 (-)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
KU514_RS13235 (KU514_13150)	-	2651815..2652015 (+)	201	WP_000180460.1	DUF1128 family protein	-
KU514_RS13240 (KU514_13155)	-	2652018..2653274 (+)	1257	WP_072419726.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=585100 KU514_RS13210 WP_001017131.1 2647653..2648696(+) (vraS) [Staphylococcus aureus strain 278]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=585100 KU514_RS13210 WP_001017131.1 2647653..2648696(+) (vraS) [Staphylococcus aureus strain 278]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTAATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGCATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCATACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAATTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTGGCTCGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGTTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCGATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1