Detailed information NTG0584981

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: KU502_RS01215
• Genome accession: NZ_CP077916
• Coordinates: 229998..231041 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain 281
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 224998..236041

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
KU502_RS01185 (KU502_01180)	-	225416..226672 (-)	1257	WP_001789555.1	aminopeptidase	-
KU502_RS01190 (KU502_01185)	-	226675..226875 (-)	201	WP_000180460.1	DUF1128 family protein	-
KU502_RS01195 (KU502_01190)	-	227022..227486 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
KU502_RS01200 (KU502_01195)	-	227493..227768 (+)	276	WP_000428171.1	hypothetical protein	-
KU502_RS01205 (KU502_01200)	-	228046..229263 (+)	1218	WP_000037075.1	YihY/virulence factor BrkB family protein	-
KU502_RS01210 (KU502_01205)	vraR	229379..230008 (-)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
KU502_RS01215 (KU502_01210)	vraS	229998..231041 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
KU502_RS01220 (KU502_01215)	liaF	231038..231739 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
KU502_RS01225 (KU502_01220)	-	231754..232140 (-)	387	WP_001110179.1	hypothetical protein	-
KU502_RS01230 (KU502_01225)	map	232357..233115 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
KU502_RS01235 (KU502_01230)	-	233646..234632 (+)	987	WP_000999716.1	FUSC family protein	-
KU502_RS01240 (KU502_01235)	-	235122..235535 (-)	414	WP_001670387.1	hypothetical protein	-
KU502_RS01245 (KU502_01240)	-	235564..235674 (-)	111	WP_001790257.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=584981 KU502_RS01215 WP_001017131.1 229998..231041(-) (vraS) [Staphylococcus aureus strain 281]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=584981 KU502_RS01215 WP_001017131.1 229998..231041(-) (vraS) [Staphylococcus aureus strain 281]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTATTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCATACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAGTTGCATAAGTTGCGACTTAAAACTCAAAATTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTGGCTCGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTTTCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1