Detailed information    

insolico Bioinformatically predicted

Overview

Name   agrA   Type   Regulator
Locus tag   KU535_RS12430 Genome accession   NZ_CP077915
Coordinates   2561628..2562344 (-) Length   238 a.a.
NCBI ID   WP_000688498.1    Uniprot ID   Q2VG52
Organism   Staphylococcus aureus strain 282     
Function   promote expression of competence genes (predicted from homology)   
Competence regulation

Genomic Context

Location: 2556628..2567344
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  KU535_RS12410 (KU535_12355) - 2557720..2558670 (+) 951 WP_000790329.1 LacI family DNA-binding transcriptional regulator -
  KU535_RS12415 (KU535_12360) - 2558819..2560303 (+) 1485 WP_000141411.1 sucrose-6-phosphate hydrolase -
  KU535_RS12420 (KU535_12365) - 2560300..2561259 (+) 960 WP_001253291.1 carbohydrate kinase family protein -
  KU535_RS12425 (KU535_12370) - 2561447..2561556 (-) 110 Protein_2446 hypothetical protein -
  KU535_RS12430 (KU535_12375) agrA 2561628..2562344 (-) 717 WP_000688498.1 quorum-sensing response regulator AgrA Regulator
  KU535_RS12435 (KU535_12380) agrC 2562363..2563646 (-) 1284 WP_047928561.1 quorum-sensing sensor histidine kinase AgrC -
  KU535_RS12440 (KU535_12385) agrD 2563676..2563819 (-) 144 WP_001094921.1 cyclic lactone autoinducer peptide AgrD -
  KU535_RS12445 (KU535_12390) - 2563822..2564385 (-) 564 WP_001105696.1 accessory gene regulator AgrB -
  KU535_RS13500 hld 2564675..2564755 (+) 81 WP_000046022.1 delta-hemolysin -
  KU535_RS12455 (KU535_12400) - 2565355..2566140 (-) 786 WP_000867950.1 carbon-nitrogen family hydrolase -
  KU535_RS12460 (KU535_12405) - 2566501..2567127 (-) 627 WP_225806585.1 nitroreductase family protein -

Sequence

Protein


Download         Length: 238 a.a.        Molecular weight: 27933.91 Da        Isoelectric Point: 6.0927

>NTDB_id=584972 KU535_RS12430 WP_000688498.1 2561628..2562344(-) (agrA) [Staphylococcus aureus strain 282]
MKIFICEDDPKQRENMVTIIKNYIMIEEKPMEIALATDNPYEVLEQAKNMNDIGCYFLDIQLSTDINGIKLGSEIRKHDP
VGNIIFVTSHSELTYLTFVYKVAAMDFIFKDDPAELRTRIIDCLETAHTRLQLLSRDNSVETIELKRGSNSVYVQYDDIM
FFESSTKSHRLIAHLDNRQIEFYGNLKELSQLDDRFFRCHNSFVVNRHNIESIDSKERIVYFKNKEHCYASVRNVKKI

Nucleotide


Download         Length: 717 bp        

>NTDB_id=584972 KU535_RS12430 WP_000688498.1 2561628..2562344(-) (agrA) [Staphylococcus aureus strain 282]
ATGAAAATTTTCATTTGCGAAGACGATCCAAAACAAAGAGAAAACATGGTTACCATTATTAAAAATTATATAATGATAGA
AGAAAAGCCTATGGAAATTGCCCTCGCAACTGATAATCCTTATGAGGTGCTTGAGCAAGCTAAAAATATGAATGACATAG
GCTGTTACTTTTTAGATATTCAACTTTCAACTGATATTAATGGTATCAAATTAGGCAGTGAAATTCGTAAGCATGACCCA
GTTGGTAACATTATTTTCGTTACGAGTCACAGTGAACTTACCTATTTAACATTTGTCTACAAAGTTGCAGCGATGGATTT
TATTTTTAAAGATGATCCAGCAGAATTAAGAACTCGAATTATAGATTGTTTAGAAACTGCACATACACGTTTACAATTAT
TATCAAGAGATAATAGCGTTGAAACGATTGAATTAAAACGTGGCAGTAATTCAGTGTATGTTCAATATGATGATATTATG
TTTTTTGAATCATCAACAAAATCTCACAGACTCATTGCCCATTTAGATAACCGTCAAATTGAATTTTATGGTAATTTAAA
AGAACTGAGTCAATTAGATGATCGTTTCTTTAGATGTCATAATAGCTTTGTCGTCAATCGCCATAATATTGAATCTATAG
ATTCGAAAGAGCGAATTGTCTATTTTAAAAATAAAGAACACTGCTATGCATCGGTGAGAAACGTTAAAAAAATATAA

Domains

Predicted by InterproScan.

LytTr DNA-binding domain (LytTR)

(151-237)

Response regulator receiver domain (Response_reg)

(3-120)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB Q2VG52

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  agrA Staphylococcus aureus N315

99.58

100

0.996