Detailed information NTG0584925

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: KU501_RS10265
• Genome accession: NZ_CP077911
• Coordinates: 2074109..2075152 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain 318
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2069109..2080152

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
KU501_RS10235 (KU501_10175)	-	2069530..2070786 (-)	1257	WP_001793983.1	aminopeptidase	-
KU501_RS10240 (KU501_10180)	-	2070789..2070989 (-)	201	WP_000180460.1	DUF1128 family protein	-
KU501_RS10245 (KU501_10185)	-	2071136..2071600 (+)	465	WP_000228670.1	low molecular weight protein-tyrosine-phosphatase	-
KU501_RS10250 (KU501_10190)	-	2071607..2071882 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
KU501_RS10255 (KU501_10195)	-	2072160..2073377 (+)	1218	WP_000037081.1	YihY/virulence factor BrkB family protein	-
KU501_RS10260 (KU501_10200)	vraR	2073490..2074119 (-)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
KU501_RS10265 (KU501_10205)	vraS	2074109..2075152 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
KU501_RS10270 (KU501_10210)	liaF	2075149..2075850 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
KU501_RS10275 (KU501_10215)	-	2075865..2076251 (-)	387	WP_001110178.1	hypothetical protein	-
KU501_RS10280 (KU501_10220)	map	2076468..2077226 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
KU501_RS10285 (KU501_10225)	-	2077926..2078912 (+)	987	WP_001014423.1	FUSC family protein	-
KU501_RS10290 (KU501_10230)	-	2079101..2079514 (-)	414	WP_001643743.1	hypothetical protein	-
KU501_RS10295 (KU501_10235)	-	2079543..2079653 (-)	111	WP_001790257.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=584925 KU501_RS10265 WP_001017131.1 2074109..2075152(-) (vraS) [Staphylococcus aureus strain 318]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=584925 KU501_RS10265 WP_001017131.1 2074109..2075152(-) (vraS) [Staphylococcus aureus strain 318]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGACTT
ATACCATACACTTGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTTTCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGCTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1