Detailed information NTG0584872

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: KU527_RS05255
• Genome accession: NZ_CP077908
• Coordinates: 1063762..1064805 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain 322
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1058762..1069805

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
KU527_RS05225 (KU527_05205)	-	1059183..1060373 (-)	1191	WP_411896787.1	aminopeptidase	-
KU527_RS05230 (KU527_05210)	-	1060442..1060642 (-)	201	WP_000180459.1	DUF1128 family protein	-
KU527_RS05235 (KU527_05215)	-	1060789..1061253 (+)	465	WP_000228668.1	low molecular weight protein-tyrosine-phosphatase	-
KU527_RS05240 (KU527_05220)	-	1061260..1061535 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
KU527_RS05245 (KU527_05225)	-	1061813..1063030 (+)	1218	WP_000037083.1	YihY/virulence factor BrkB family protein	-
KU527_RS05250 (KU527_05230)	vraR	1063143..1063772 (-)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
KU527_RS05255 (KU527_05235)	vraS	1063762..1064805 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
KU527_RS05260 (KU527_05240)	liaF	1064802..1065503 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
KU527_RS05265 (KU527_05245)	-	1065518..1065904 (-)	387	WP_001110184.1	hypothetical protein	-
KU527_RS05270 (KU527_05250)	map	1066121..1066879 (-)	759	WP_000636137.1	type I methionyl aminopeptidase	-
KU527_RS05275 (KU527_05255)	-	1067410..1068396 (+)	987	WP_000999713.1	FUSC family protein	-
KU527_RS05280 (KU527_05260)	-	1068574..1068987 (-)	414	WP_001622129.1	hypothetical protein	-
KU527_RS05285 (KU527_05265)	-	1069016..1069125 (-)	110	Protein_1012	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=584872 KU527_RS05255 WP_001017131.1 1063762..1064805(-) (vraS) [Staphylococcus aureus strain 322]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=584872 KU527_RS05255 WP_001017131.1 1063762..1064805(-) (vraS) [Staphylococcus aureus strain 322]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTACCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTCGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1