Detailed information NTG0584841

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: KU505_RS10015
• Genome accession: NZ_CP077899
• Coordinates: 2062998..2064041 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain 324
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2057998..2069041

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
KU505_RS09985 (KU505_09920)	-	2058419..2059675 (-)	1257	WP_001793983.1	aminopeptidase	-
KU505_RS09990 (KU505_09925)	-	2059678..2059878 (-)	201	WP_000180460.1	DUF1128 family protein	-
KU505_RS09995 (KU505_09930)	-	2060025..2060489 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
KU505_RS10000 (KU505_09935)	-	2060496..2060771 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
KU505_RS10005 (KU505_09940)	-	2061049..2062266 (+)	1218	WP_000037083.1	YihY/virulence factor BrkB family protein	-
KU505_RS10010 (KU505_09945)	vraR	2062379..2063008 (-)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
KU505_RS10015 (KU505_09950)	vraS	2062998..2064041 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
KU505_RS10020 (KU505_09955)	liaF	2064038..2064739 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
KU505_RS10025 (KU505_09960)	-	2064754..2065140 (-)	387	WP_001110184.1	hypothetical protein	-
KU505_RS10030 (KU505_09965)	map	2065357..2066115 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
KU505_RS10035 (KU505_09970)	-	2066646..2067632 (+)	987	WP_000999713.1	FUSC family protein	-
KU505_RS10040 (KU505_09975)	-	2067808..2068224 (-)	417	WP_225806085.1	hypothetical protein	-
KU505_RS10045 (KU505_09980)	-	2068253..2068363 (-)	111	WP_031926705.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=584841 KU505_RS10015 WP_001017131.1 2062998..2064041(-) (vraS) [Staphylococcus aureus strain 324]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=584841 KU505_RS10015 WP_001017131.1 2062998..2064041(-) (vraS) [Staphylococcus aureus strain 324]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAGTTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGATCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTACCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTCGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1