Detailed information NTG0584739

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: KU544_RS10110
• Genome accession: NZ_CP077897
• Coordinates: 2015496..2016539 (+)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain 328
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2010496..2021539

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
KU544_RS10080 (KU544_10055)	-	2011176..2011285 (+)	110	Protein_1982	hypothetical protein	-
KU544_RS10085 (KU544_10060)	-	2011314..2011727 (+)	414	WP_001622129.1	hypothetical protein	-
KU544_RS10090 (KU544_10065)	-	2011905..2012891 (-)	987	WP_000999713.1	FUSC family protein	-
KU544_RS10095 (KU544_10070)	map	2013422..2014180 (+)	759	WP_000636137.1	type I methionyl aminopeptidase	-
KU544_RS10100 (KU544_10075)	-	2014397..2014783 (+)	387	WP_001110184.1	hypothetical protein	-
KU544_RS10105 (KU544_10080)	liaF	2014798..2015499 (+)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
KU544_RS10110 (KU544_10085)	vraS	2015496..2016539 (+)	1044	WP_001017131.1	sensor histidine kinase	Regulator
KU544_RS10115 (KU544_10090)	vraR	2016529..2017158 (+)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
KU544_RS10120 (KU544_10095)	-	2017271..2018488 (-)	1218	WP_000037083.1	YihY/virulence factor BrkB family protein	-
KU544_RS10125 (KU544_10100)	-	2018766..2019041 (-)	276	WP_000428172.1	YtxH domain-containing protein	-
KU544_RS10130 (KU544_10105)	-	2019048..2019512 (-)	465	WP_000228668.1	low molecular weight protein-tyrosine-phosphatase	-
KU544_RS10135 (KU544_10110)	-	2019659..2019859 (+)	201	WP_000180459.1	DUF1128 family protein	-
KU544_RS10140 (KU544_10115)	-	2019928..2021118 (+)	1191	WP_411896787.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=584739 KU544_RS10110 WP_001017131.1 2015496..2016539(+) (vraS) [Staphylococcus aureus strain 328]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=584739 KU544_RS10110 WP_001017131.1 2015496..2016539(+) (vraS) [Staphylococcus aureus strain 328]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTACCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTCGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1