Detailed information NTG0584687

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: KU540_RS06725
• Genome accession: NZ_CP077894
• Coordinates: 1345325..1346368 (+)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain 329
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1340325..1351368

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
KU540_RS06695 (KU540_06655)	-	1341003..1341113 (+)	111	WP_031926705.1	hypothetical protein	-
KU540_RS06700 (KU540_06660)	-	1341142..1341558 (+)	417	WP_225806085.1	hypothetical protein	-
KU540_RS06705 (KU540_06665)	-	1341734..1342720 (-)	987	WP_000999713.1	FUSC family protein	-
KU540_RS06710 (KU540_06670)	map	1343251..1344009 (+)	759	WP_000636142.1	type I methionyl aminopeptidase	-
KU540_RS06715 (KU540_06675)	-	1344226..1344612 (+)	387	WP_001110184.1	hypothetical protein	-
KU540_RS06720 (KU540_06680)	liaF	1344627..1345328 (+)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
KU540_RS06725 (KU540_06685)	vraS	1345325..1346368 (+)	1044	WP_001017131.1	sensor histidine kinase	Regulator
KU540_RS06730 (KU540_06690)	vraR	1346358..1346987 (+)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
KU540_RS06735 (KU540_06695)	-	1347100..1348317 (-)	1218	WP_000037083.1	YihY/virulence factor BrkB family protein	-
KU540_RS06740 (KU540_06700)	-	1348595..1348870 (-)	276	WP_000428172.1	YtxH domain-containing protein	-
KU540_RS06745 (KU540_06705)	-	1348877..1349341 (-)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
KU540_RS06750 (KU540_06710)	-	1349488..1349688 (+)	201	WP_000180460.1	DUF1128 family protein	-
KU540_RS06755 (KU540_06715)	-	1349691..1350947 (+)	1257	WP_001793983.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=584687 KU540_RS06725 WP_001017131.1 1345325..1346368(+) (vraS) [Staphylococcus aureus strain 329]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=584687 KU540_RS06725 WP_001017131.1 1345325..1346368(+) (vraS) [Staphylococcus aureus strain 329]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAGTTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGATCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTACCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTCGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1