Detailed information
Bioinformatically predicted
Overview
| Name | agrA | Type | Regulator |
| Locus tag | KU540_RS05895 | Genome accession | NZ_CP077894 |
| Coordinates | 1214029..1214745 (-) | Length | 238 a.a. |
| NCBI ID | WP_000688492.1 | Uniprot ID | A0A7U7IEW1 |
| Organism | Staphylococcus aureus strain 329 | ||
| Function | promote expression of competence genes (predicted from homology) Competence regulation |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| ICE | 1177012..1229515 | 1214029..1214745 | within | 0 |
Gene organization within MGE regions
Location: 1177012..1229515
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KU540_RS05710 (KU540_05675) | - | 1177980..1179338 (-) | 1359 | WP_001251190.1 | FtsK/SpoIIIE domain-containing protein | - |
| KU540_RS05715 (KU540_05680) | - | 1179401..1179667 (-) | 267 | WP_000453449.1 | hypothetical protein | - |
| KU540_RS05720 (KU540_05685) | - | 1179905..1180381 (+) | 477 | WP_001031902.1 | hypothetical protein | - |
| KU540_RS05725 (KU540_05690) | - | 1180554..1183049 (-) | 2496 | WP_001049261.1 | ATP-binding protein | - |
| KU540_RS05730 (KU540_05695) | - | 1183084..1183467 (-) | 384 | WP_000358144.1 | TcpE family conjugal transfer membrane protein | - |
| KU540_RS05735 (KU540_05700) | - | 1183479..1183739 (-) | 261 | WP_000015639.1 | TcpD family membrane protein | - |
| KU540_RS05740 (KU540_05705) | - | 1183744..1184799 (-) | 1056 | WP_000692002.1 | conjugal transfer protein | - |
| KU540_RS05745 (KU540_05710) | - | 1184860..1185951 (-) | 1092 | WP_000173102.1 | replication initiation factor domain-containing protein | - |
| KU540_RS05750 (KU540_05715) | - | 1186126..1186428 (-) | 303 | WP_225805900.1 | hypothetical protein | - |
| KU540_RS05755 (KU540_05720) | - | 1186442..1186762 (-) | 321 | WP_000805734.1 | DUF961 family protein | - |
| KU540_RS05760 (KU540_05725) | - | 1186913..1187197 (-) | 285 | WP_000134542.1 | hypothetical protein | - |
| KU540_RS05765 (KU540_05730) | - | 1187296..1187712 (+) | 417 | WP_000688537.1 | hypothetical protein | - |
| KU540_RS05770 (KU540_05735) | ilvA | 1187789..1189056 (-) | 1268 | Protein_1124 | threonine ammonia-lyase IlvA | - |
| KU540_RS05775 (KU540_05740) | leuD | 1189071..1189643 (-) | 573 | WP_000718956.1 | 3-isopropylmalate dehydratase small subunit | - |
| KU540_RS05780 (KU540_05745) | leuC | 1189644..1191014 (-) | 1371 | WP_000531827.1 | 3-isopropylmalate dehydratase large subunit | - |
| KU540_RS05785 (KU540_05750) | leuB | 1191028..1192074 (-) | 1047 | WP_000221939.1 | 3-isopropylmalate dehydrogenase | - |
| KU540_RS05790 (KU540_05755) | - | 1192077..1193606 (-) | 1530 | WP_000094576.1 | 2-isopropylmalate synthase | - |
| KU540_RS05795 (KU540_05760) | ilvC | 1193636..1194640 (-) | 1005 | WP_000214552.1 | ketol-acid reductoisomerase | - |
| KU540_RS05800 (KU540_05765) | - | 1194777..1195031 (-) | 255 | WP_000196911.1 | ACT domain-containing protein | - |
| KU540_RS05805 (KU540_05770) | ilvB | 1195031..1196800 (-) | 1770 | WP_225805899.1 | biosynthetic-type acetolactate synthase large subunit | - |
| KU540_RS05810 (KU540_05775) | ilvD | 1196833..1198521 (-) | 1689 | WP_001255780.1 | dihydroxy-acid dehydratase | - |
| KU540_RS05815 (KU540_05780) | - | 1198839..1198994 (-) | 156 | WP_001791591.1 | hypothetical protein | - |
| KU540_RS05820 (KU540_05785) | tsaE | 1199032..1199493 (+) | 462 | WP_000590801.1 | tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex ATPase subunit type 1 TsaE | - |
| KU540_RS05825 (KU540_05790) | tsaB | 1199474..1200136 (+) | 663 | WP_001086733.1 | tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex dimerization subunit type 1 TsaB | - |
| KU540_RS05830 (KU540_05795) | rimI | 1200109..1200573 (+) | 465 | WP_000372753.1 | ribosomal protein S18-alanine N-acetyltransferase | - |
| KU540_RS05835 (KU540_05800) | tsaD | 1200566..1201591 (+) | 1026 | WP_000159047.1 | tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex transferase subunit TsaD | - |
| KU540_RS05840 (KU540_05805) | - | 1202023..1203633 (-) | 1611 | WP_060649654.1 | MutS family DNA mismatch repair protein | - |
| KU540_RS05845 (KU540_05810) | - | 1203722..1203835 (+) | 114 | WP_078064143.1 | hypothetical protein | - |
| KU540_RS05850 (KU540_05815) | - | 1203995..1205923 (-) | 1929 | WP_000602061.1 | ABC-F family ATP-binding cassette domain-containing protein | - |
| KU540_RS05855 (KU540_05820) | - | 1206176..1206811 (+) | 636 | WP_001283612.1 | redox-sensing transcriptional repressor Rex | - |
| KU540_RS05860 (KU540_05825) | - | 1207115..1208194 (+) | 1080 | WP_225805898.1 | YeeE/YedE family protein | - |
| KU540_RS05865 (KU540_05830) | - | 1208254..1208478 (+) | 225 | WP_000581077.1 | sulfurtransferase TusA family protein | - |
| KU540_RS05870 (KU540_05835) | - | 1208687..1209937 (+) | 1251 | WP_001052281.1 | ammonium transporter | - |
| KU540_RS05875 (KU540_05840) | - | 1210121..1211071 (+) | 951 | WP_000790314.1 | LacI family DNA-binding transcriptional regulator | - |
| KU540_RS05880 (KU540_05845) | - | 1211220..1212704 (+) | 1485 | WP_000141419.1 | sucrose-6-phosphate hydrolase | - |
| KU540_RS05885 (KU540_05850) | - | 1212701..1213660 (+) | 960 | WP_001253296.1 | carbohydrate kinase family protein | - |
| KU540_RS05890 (KU540_05855) | - | 1213850..1213957 (-) | 108 | WP_031785433.1 | hypothetical protein | - |
| KU540_RS05895 (KU540_05860) | agrA | 1214029..1214745 (-) | 717 | WP_000688492.1 | quorum-sensing response regulator AgrA | Regulator |
| KU540_RS05900 (KU540_05865) | agrC | 1214764..1216056 (-) | 1293 | WP_001657119.1 | quorum-sensing sensor histidine kinase AgrC | - |
| KU540_RS05905 (KU540_05870) | agrD | 1216081..1216221 (-) | 141 | WP_001093929.1 | cyclic lactone autoinducer peptide AgrD | - |
| KU540_RS05910 (KU540_05875) | agrB | 1216218..1216787 (-) | 570 | WP_001105708.1 | accessory gene regulator AgrB | - |
| KU540_RS14340 | hld | 1217077..1217157 (+) | 81 | WP_000046022.1 | delta-hemolysin | - |
| KU540_RS05920 (KU540_05885) | - | 1217757..1218542 (-) | 786 | WP_000867944.1 | carbon-nitrogen family hydrolase | - |
| KU540_RS05925 (KU540_05890) | - | 1219012..1219638 (-) | 627 | WP_000522375.1 | nitroreductase family protein | - |
| KU540_RS05930 (KU540_05895) | - | 1219835..1221043 (+) | 1209 | WP_000120328.1 | SdrH family protein | - |
| KU540_RS05935 (KU540_05900) | mroQ | 1221068..1221811 (-) | 744 | WP_000197628.1 | CPBP family intramembrane glutamic endopeptidase MroQ | - |
| KU540_RS05940 (KU540_05905) | groES | 1221986..1222270 (+) | 285 | WP_000917289.1 | co-chaperone GroES | - |
| KU540_RS05945 (KU540_05910) | groL | 1222346..1223962 (+) | 1617 | WP_000240652.1 | chaperonin GroEL | - |
| KU540_RS05950 (KU540_05915) | - | 1224031..1225203 (-) | 1173 | WP_111187478.1 | tyrosine-type recombinase/integrase | - |
| KU540_RS05955 (KU540_05920) | - | 1225217..1225939 (-) | 723 | WP_000672427.1 | helix-turn-helix domain-containing protein | - |
| KU540_RS05960 (KU540_05925) | - | 1226092..1226298 (+) | 207 | WP_000794657.1 | helix-turn-helix domain-containing protein | - |
| KU540_RS05965 (KU540_05930) | - | 1226302..1226619 (+) | 318 | WP_000481971.1 | helix-turn-helix domain-containing protein | - |
| KU540_RS05970 (KU540_05935) | - | 1226616..1226771 (+) | 156 | WP_053016798.1 | hypothetical protein | - |
| KU540_RS05975 (KU540_05940) | - | 1226756..1226959 (+) | 204 | WP_111187479.1 | pathogenicity island protein | - |
| KU540_RS05980 (KU540_05945) | - | 1226961..1227344 (+) | 384 | WP_060649652.1 | hypothetical protein | - |
| KU540_RS05985 (KU540_05950) | tscT | 1227345..1227638 (+) | 294 | WP_001103953.1 | type II toxin-antitoxin system toxin TscT | - |
| KU540_RS05990 (KU540_05955) | - | 1227726..1228595 (+) | 870 | WP_225805897.1 | primase alpha helix C-terminal domain-containing protein | - |
Sequence
Protein
Download Length: 238 a.a. Molecular weight: 27905.90 Da Isoelectric Point: 6.0927
>NTDB_id=584686 KU540_RS05895 WP_000688492.1 1214029..1214745(-) (agrA) [Staphylococcus aureus strain 329]
MKIFICEDDPKQRENMVTIIKNYIMIEEKPMEIALATDNPYEVLEQAKNMNDIGCYFLDIQLSTDINGIKLGSEIRKHDP
VGNIIFVTSHSELTYLTFVYKVAAMDFIFKDDPAELRTRIIDCLETAHTRLQLLSKDNSVETIELKRGSNSVYVQYDDIM
FFESSTKSHRLIAHLDNRQIEFYGNLKELSQLDDRFFRCHNSFVVNRHNIESIDSKERIVYFKNKEHCYASVRNVKKI
MKIFICEDDPKQRENMVTIIKNYIMIEEKPMEIALATDNPYEVLEQAKNMNDIGCYFLDIQLSTDINGIKLGSEIRKHDP
VGNIIFVTSHSELTYLTFVYKVAAMDFIFKDDPAELRTRIIDCLETAHTRLQLLSKDNSVETIELKRGSNSVYVQYDDIM
FFESSTKSHRLIAHLDNRQIEFYGNLKELSQLDDRFFRCHNSFVVNRHNIESIDSKERIVYFKNKEHCYASVRNVKKI
Nucleotide
Download Length: 717 bp
>NTDB_id=584686 KU540_RS05895 WP_000688492.1 1214029..1214745(-) (agrA) [Staphylococcus aureus strain 329]
ATGAAAATTTTCATTTGCGAAGACGATCCAAAACAAAGAGAAAACATGGTTACCATTATCAAAAATTATATAATGATAGA
AGAAAAGCCTATGGAAATTGCCCTCGCAACTGATAATCCTTATGAGGTGCTTGAGCAAGCTAAAAATATGAATGACATAG
GCTGTTACTTTTTAGATATTCAACTTTCAACTGATATTAATGGTATCAAATTAGGCAGTGAAATTCGTAAGCATGACCCA
GTTGGTAACATTATTTTCGTTACGAGTCACAGTGAACTTACGTATTTAACATTTGTCTACAAAGTTGCAGCGATGGATTT
TATTTTTAAGGATGATCCAGCAGAATTAAGAACACGTATTATAGACTGTTTAGAAACTGCACATACACGCTTACAATTAT
TATCAAAAGATAATAGCGTTGAAACGATTGAGTTAAAACGTGGCAGTAATTCTGTGTATGTTCAATATGATGATATTATG
TTTTTTGAATCATCAACTAAGTCACACAGACTCATTGCGCATTTAGACAATCGTCAAATTGAATTTTATGGTAATTTAAA
AGAACTGAGTCAATTAGATGATCGCTTCTTCAGATGTCATAATAGCTTTGTCGTCAATCGCCATAATATTGAATCTATTG
ATTCGAAAGAGCGAATTGTCTATTTTAAAAATAAAGAACACTGCTATGCATCGGTGAGAAACGTTAAAAAAATATAA
ATGAAAATTTTCATTTGCGAAGACGATCCAAAACAAAGAGAAAACATGGTTACCATTATCAAAAATTATATAATGATAGA
AGAAAAGCCTATGGAAATTGCCCTCGCAACTGATAATCCTTATGAGGTGCTTGAGCAAGCTAAAAATATGAATGACATAG
GCTGTTACTTTTTAGATATTCAACTTTCAACTGATATTAATGGTATCAAATTAGGCAGTGAAATTCGTAAGCATGACCCA
GTTGGTAACATTATTTTCGTTACGAGTCACAGTGAACTTACGTATTTAACATTTGTCTACAAAGTTGCAGCGATGGATTT
TATTTTTAAGGATGATCCAGCAGAATTAAGAACACGTATTATAGACTGTTTAGAAACTGCACATACACGCTTACAATTAT
TATCAAAAGATAATAGCGTTGAAACGATTGAGTTAAAACGTGGCAGTAATTCTGTGTATGTTCAATATGATGATATTATG
TTTTTTGAATCATCAACTAAGTCACACAGACTCATTGCGCATTTAGACAATCGTCAAATTGAATTTTATGGTAATTTAAA
AGAACTGAGTCAATTAGATGATCGCTTCTTCAGATGTCATAATAGCTTTGTCGTCAATCGCCATAATATTGAATCTATTG
ATTCGAAAGAGCGAATTGTCTATTTTAAAAATAAAGAACACTGCTATGCATCGGTGAGAAACGTTAAAAAAATATAA
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| agrA | Staphylococcus aureus N315 |
100 |
100 |
1 |