Detailed information NTG0584642

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: KU542_RS03570
• Genome accession: NZ_CP077893
• Coordinates: 676736..677779 (+)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain 332
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 671736..682779

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
KU542_RS03540 (KU542_03540)	-	672120..672230 (+)	111	WP_001790257.1	hypothetical protein	-
KU542_RS03545 (KU542_03545)	-	672259..672672 (+)	414	WP_001549145.1	hypothetical protein	-
KU542_RS03550 (KU542_03550)	-	673103..674075 (-)	973	Protein_697	FUSC family protein	-
KU542_RS03555 (KU542_03555)	map	674662..675420 (+)	759	WP_000636142.1	type I methionyl aminopeptidase	-
KU542_RS03560 (KU542_03560)	-	675637..676023 (+)	387	WP_001110179.1	hypothetical protein	-
KU542_RS03565 (KU542_03565)	liaF	676038..676739 (+)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
KU542_RS03570 (KU542_03570)	vraS	676736..677779 (+)	1044	WP_001017131.1	sensor histidine kinase	Regulator
KU542_RS03575 (KU542_03575)	vraR	677769..678398 (+)	630	WP_000153530.1	two-component system response regulator VraR	Regulator
KU542_RS03580 (KU542_03580)	-	678514..679731 (-)	1218	WP_000037075.1	YihY/virulence factor BrkB family protein	-
KU542_RS03585 (KU542_03585)	-	680009..680284 (-)	276	WP_000428172.1	YtxH domain-containing protein	-
KU542_RS03590 (KU542_03590)	-	680291..680755 (-)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
KU542_RS03595 (KU542_03595)	-	680902..681102 (+)	201	WP_000180461.1	DUF1128 family protein	-
KU542_RS03600 (KU542_03600)	-	681105..682361 (+)	1257	WP_001795438.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=584642 KU542_RS03570 WP_001017131.1 676736..677779(+) (vraS) [Staphylococcus aureus strain 332]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=584642 KU542_RS03570 WP_001017131.1 676736..677779(+) (vraS) [Staphylococcus aureus strain 332]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTGAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTTTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
TATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGATAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1