Detailed information NTG0584473

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: KU497_RS02755
• Genome accession: NZ_CP077880
• Coordinates: 535470..536513 (+)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain 356
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 530470..541513

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
KU497_RS02725 (KU497_02715)	-	530840..530950 (+)	111	WP_001790257.1	hypothetical protein	-
KU497_RS02730 (KU497_02720)	-	530979..531392 (+)	414	WP_001549145.1	hypothetical protein	-
KU497_RS02735 (KU497_02725)	-	531882..532868 (-)	987	WP_000999713.1	FUSC family protein	-
KU497_RS02740 (KU497_02730)	map	533396..534154 (+)	759	WP_000636142.1	type I methionyl aminopeptidase	-
KU497_RS02745 (KU497_02735)	-	534371..534757 (+)	387	WP_031896188.1	hypothetical protein	-
KU497_RS02750 (KU497_02740)	liaF	534772..535473 (+)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
KU497_RS02755 (KU497_02745)	vraS	535470..536513 (+)	1044	WP_001017131.1	sensor histidine kinase	Regulator
KU497_RS02760 (KU497_02750)	vraR	536503..537132 (+)	630	WP_000153530.1	two-component system response regulator VraR	Regulator
KU497_RS02765 (KU497_02755)	-	537248..538465 (-)	1218	WP_000037075.1	YihY/virulence factor BrkB family protein	-
KU497_RS02770 (KU497_02760)	-	538743..539018 (-)	276	WP_000428172.1	YtxH domain-containing protein	-
KU497_RS02775 (KU497_02765)	-	539025..539489 (-)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
KU497_RS02780 (KU497_02770)	-	539636..539836 (+)	201	WP_000180461.1	DUF1128 family protein	-
KU497_RS02785 (KU497_02775)	-	539839..541095 (+)	1257	WP_001795438.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=584473 KU497_RS02755 WP_001017131.1 535470..536513(+) (vraS) [Staphylococcus aureus strain 356]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=584473 KU497_RS02755 WP_001017131.1 535470..536513(+) (vraS) [Staphylococcus aureus strain 356]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTTTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
TATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGATAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1