Detailed information NTG0584384

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: KU513_RS00635
• Genome accession: NZ_CP077872
• Coordinates: 124590..125633 (+)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain 358
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 119590..130633

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
KU513_RS00605 (KU513_00605)	-	119960..120070 (+)	111	WP_001790257.1	hypothetical protein	-
KU513_RS00610 (KU513_00610)	-	120099..120512 (+)	414	WP_001549145.1	hypothetical protein	-
KU513_RS00615 (KU513_00615)	-	121002..121988 (-)	987	WP_000999713.1	FUSC family protein	-
KU513_RS00620 (KU513_00620)	map	122516..123274 (+)	759	WP_000636142.1	type I methionyl aminopeptidase	-
KU513_RS00625 (KU513_00625)	-	123491..123877 (+)	387	WP_031896188.1	hypothetical protein	-
KU513_RS00630 (KU513_00630)	liaF	123892..124593 (+)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
KU513_RS00635 (KU513_00635)	vraS	124590..125633 (+)	1044	WP_001017131.1	sensor histidine kinase	Regulator
KU513_RS00640 (KU513_00640)	vraR	125623..126252 (+)	630	WP_000153530.1	two-component system response regulator VraR	Regulator
KU513_RS00645 (KU513_00645)	-	126368..127585 (-)	1218	WP_000037075.1	YihY/virulence factor BrkB family protein	-
KU513_RS00650 (KU513_00650)	-	127863..128138 (-)	276	WP_000428172.1	YtxH domain-containing protein	-
KU513_RS00655 (KU513_00655)	-	128145..128609 (-)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
KU513_RS00660 (KU513_00660)	-	128756..128956 (+)	201	WP_000180461.1	DUF1128 family protein	-
KU513_RS00665 (KU513_00665)	-	128959..130215 (+)	1257	WP_001795438.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=584384 KU513_RS00635 WP_001017131.1 124590..125633(+) (vraS) [Staphylococcus aureus strain 358]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=584384 KU513_RS00635 WP_001017131.1 124590..125633(+) (vraS) [Staphylococcus aureus strain 358]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTTTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
TATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGATAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1