Detailed information NTG0584376

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: KU523_RS10315
• Genome accession: NZ_CP077870
• Coordinates: 2049989..2051032 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain 360
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2044989..2056032

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
KU523_RS10285 (KU523_10265)	-	2045407..2046663 (-)	1257	WP_001795438.1	aminopeptidase	-
KU523_RS10290 (KU523_10270)	-	2046666..2046866 (-)	201	WP_000180461.1	DUF1128 family protein	-
KU523_RS10295 (KU523_10275)	-	2047013..2047477 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
KU523_RS10300 (KU523_10280)	-	2047484..2047759 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
KU523_RS10305 (KU523_10285)	-	2048037..2049254 (+)	1218	WP_000037075.1	YihY/virulence factor BrkB family protein	-
KU523_RS10310 (KU523_10290)	vraR	2049370..2049999 (-)	630	WP_000153530.1	two-component system response regulator VraR	Regulator
KU523_RS10315 (KU523_10295)	vraS	2049989..2051032 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
KU523_RS10320 (KU523_10300)	liaF	2051029..2051730 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
KU523_RS10325 (KU523_10305)	-	2051745..2052131 (-)	387	WP_031896188.1	hypothetical protein	-
KU523_RS10330 (KU523_10310)	map	2052348..2053106 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
KU523_RS10335 (KU523_10315)	-	2053634..2054620 (+)	987	WP_000999713.1	FUSC family protein	-
KU523_RS10340 (KU523_10320)	-	2055110..2055523 (-)	414	WP_001549145.1	hypothetical protein	-
KU523_RS10345 (KU523_10325)	-	2055552..2055662 (-)	111	WP_001790257.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=584376 KU523_RS10315 WP_001017131.1 2049989..2051032(-) (vraS) [Staphylococcus aureus strain 360]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=584376 KU523_RS10315 WP_001017131.1 2049989..2051032(-) (vraS) [Staphylococcus aureus strain 360]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTTTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
TATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGATAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1