Detailed information NTG0584331

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: KU517_RS08680
• Genome accession: NZ_CP077869
• Coordinates: 1734986..1736029 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain 365
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1729986..1741029

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
KU517_RS08650 (KU517_08620)	-	1730407..1731663 (-)	1257	WP_078065149.1	aminopeptidase	-
KU517_RS08655 (KU517_08625)	-	1731666..1731866 (-)	201	WP_000180460.1	DUF1128 family protein	-
KU517_RS08660 (KU517_08630)	-	1732013..1732477 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
KU517_RS08665 (KU517_08635)	-	1732484..1732759 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
KU517_RS08670 (KU517_08640)	-	1733037..1734254 (+)	1218	WP_000037087.1	YihY/virulence factor BrkB family protein	-
KU517_RS08675 (KU517_08645)	vraR	1734367..1734996 (-)	630	WP_000153526.1	two-component system response regulator VraR	Regulator
KU517_RS08680 (KU517_08650)	vraS	1734986..1736029 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
KU517_RS08685 (KU517_08655)	liaF	1736026..1736727 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
KU517_RS08690 (KU517_08660)	-	1736742..1737128 (-)	387	WP_001110179.1	hypothetical protein	-
KU517_RS08695 (KU517_08665)	map	1737345..1738103 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
KU517_RS08700 (KU517_08670)	-	1738632..1739618 (+)	987	WP_000999708.1	FUSC family protein	-
KU517_RS08705 (KU517_08675)	-	1740051..1740464 (-)	414	WP_025174552.1	hypothetical protein	-
KU517_RS08710 (KU517_08680)	-	1740493..1740603 (-)	111	WP_001790257.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=584331 KU517_RS08680 WP_001017131.1 1734986..1736029(-) (vraS) [Staphylococcus aureus strain 365]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=584331 KU517_RS08680 WP_001017131.1 1734986..1736029(-) (vraS) [Staphylococcus aureus strain 365]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTTTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGTATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAACGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGATCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1