Detailed information NTG0584246

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: KU500_RS11955
• Genome accession: NZ_CP077867
• Coordinates: 2465747..2466790 (+)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain 367
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2460747..2471790

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
KU500_RS11925 (KU500_11890)	-	2461173..2461283 (+)	111	WP_001790257.1	hypothetical protein	-
KU500_RS11930 (KU500_11895)	-	2461312..2461725 (+)	414	WP_025174552.1	hypothetical protein	-
KU500_RS11935 (KU500_11900)	-	2462158..2463144 (-)	987	WP_000999708.1	FUSC family protein	-
KU500_RS11940 (KU500_11905)	map	2463673..2464431 (+)	759	WP_000636142.1	type I methionyl aminopeptidase	-
KU500_RS11945 (KU500_11910)	-	2464648..2465034 (+)	387	WP_001110179.1	hypothetical protein	-
KU500_RS11950 (KU500_11915)	liaF	2465049..2465750 (+)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
KU500_RS11955 (KU500_11920)	vraS	2465747..2466790 (+)	1044	WP_001017131.1	sensor histidine kinase	Regulator
KU500_RS11960 (KU500_11925)	vraR	2466780..2467409 (+)	630	WP_000153526.1	two-component system response regulator VraR	Regulator
KU500_RS11965 (KU500_11930)	-	2467522..2468739 (-)	1218	WP_000037087.1	YihY/virulence factor BrkB family protein	-
KU500_RS11970 (KU500_11935)	-	2469017..2469292 (-)	276	WP_000428172.1	YtxH domain-containing protein	-
KU500_RS11975 (KU500_11940)	-	2469299..2469763 (-)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
KU500_RS11980 (KU500_11945)	-	2469910..2470110 (+)	201	WP_000180460.1	DUF1128 family protein	-
KU500_RS11985 (KU500_11950)	-	2470113..2471369 (+)	1257	WP_078065149.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=584246 KU500_RS11955 WP_001017131.1 2465747..2466790(+) (vraS) [Staphylococcus aureus strain 367]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=584246 KU500_RS11955 WP_001017131.1 2465747..2466790(+) (vraS) [Staphylococcus aureus strain 367]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTTTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGTATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAACGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGATCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1