Detailed information NTG0584192

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: KU528_RS02965
• Genome accession: NZ_CP077865
• Coordinates: 576683..577726 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain 370
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 571683..582726

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
KU528_RS02935 (KU528_02910)	-	572104..573360 (-)	1257	WP_078065149.1	aminopeptidase	-
KU528_RS02940 (KU528_02915)	-	573363..573563 (-)	201	WP_000180460.1	DUF1128 family protein	-
KU528_RS02945 (KU528_02920)	-	573710..574174 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
KU528_RS02950 (KU528_02925)	-	574181..574456 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
KU528_RS02955 (KU528_02930)	-	574734..575951 (+)	1218	WP_000037087.1	YihY/virulence factor BrkB family protein	-
KU528_RS02960 (KU528_02935)	vraR	576064..576693 (-)	630	WP_000153526.1	two-component system response regulator VraR	Regulator
KU528_RS02965 (KU528_02940)	vraS	576683..577726 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
KU528_RS02970 (KU528_02945)	liaF	577723..578424 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
KU528_RS02975 (KU528_02950)	-	578439..578825 (-)	387	WP_001110179.1	hypothetical protein	-
KU528_RS02980 (KU528_02955)	map	579042..579800 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
KU528_RS02985 (KU528_02960)	-	580329..581315 (+)	987	WP_000999708.1	FUSC family protein	-
KU528_RS02990 (KU528_02965)	-	581748..582161 (-)	414	WP_025174552.1	hypothetical protein	-
KU528_RS02995 (KU528_02970)	-	582190..582300 (-)	111	WP_001790257.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=584192 KU528_RS02965 WP_001017131.1 576683..577726(-) (vraS) [Staphylococcus aureus strain 370]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=584192 KU528_RS02965 WP_001017131.1 576683..577726(-) (vraS) [Staphylococcus aureus strain 370]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTTTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGTATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAACGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGATCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1