Detailed information NTG0584153

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: KU524_RS11085
• Genome accession: NZ_CP077863
• Coordinates: 2309046..2310089 (+)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain 371
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2304046..2315089

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
KU524_RS11055 (KU524_11025)	-	2304472..2304582 (+)	111	WP_001790257.1	hypothetical protein	-
KU524_RS11060 (KU524_11030)	-	2304611..2305024 (+)	414	WP_025174552.1	hypothetical protein	-
KU524_RS11065 (KU524_11035)	-	2305457..2306443 (-)	987	WP_000999708.1	FUSC family protein	-
KU524_RS11070 (KU524_11040)	map	2306972..2307730 (+)	759	WP_000636142.1	type I methionyl aminopeptidase	-
KU524_RS11075 (KU524_11045)	-	2307947..2308333 (+)	387	WP_001110179.1	hypothetical protein	-
KU524_RS11080 (KU524_11050)	liaF	2308348..2309049 (+)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
KU524_RS11085 (KU524_11055)	vraS	2309046..2310089 (+)	1044	WP_001017131.1	sensor histidine kinase	Regulator
KU524_RS11090 (KU524_11060)	vraR	2310079..2310708 (+)	630	WP_000153526.1	two-component system response regulator VraR	Regulator
KU524_RS11095 (KU524_11065)	-	2310821..2312038 (-)	1218	WP_000037087.1	YihY/virulence factor BrkB family protein	-
KU524_RS11100 (KU524_11070)	-	2312316..2312591 (-)	276	WP_000428172.1	YtxH domain-containing protein	-
KU524_RS11105 (KU524_11075)	-	2312598..2313062 (-)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
KU524_RS11110 (KU524_11080)	-	2313209..2313409 (+)	201	WP_000180460.1	DUF1128 family protein	-
KU524_RS11115 (KU524_11085)	-	2313412..2314668 (+)	1257	WP_078065149.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=584153 KU524_RS11085 WP_001017131.1 2309046..2310089(+) (vraS) [Staphylococcus aureus strain 371]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=584153 KU524_RS11085 WP_001017131.1 2309046..2310089(+) (vraS) [Staphylococcus aureus strain 371]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTTTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGTATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAACGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGATCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1