Detailed information NTG0584068

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: KU521_RS04305
• Genome accession: NZ_CP077860
• Coordinates: 877884..878927 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain AC4
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 872884..883927

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
KU521_RS04275 (KU521_04265)	-	873305..874561 (-)	1257	WP_001795108.1	aminopeptidase	-
KU521_RS04280 (KU521_04270)	-	874564..874764 (-)	201	WP_000180460.1	DUF1128 family protein	-
KU521_RS04285 (KU521_04275)	-	874911..875375 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
KU521_RS04290 (KU521_04280)	-	875382..875657 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
KU521_RS04295 (KU521_04285)	-	875935..877152 (+)	1218	WP_000037075.1	YihY/virulence factor BrkB family protein	-
KU521_RS04300 (KU521_04290)	vraR	877265..877894 (-)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
KU521_RS04305 (KU521_04295)	vraS	877884..878927 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
KU521_RS04310 (KU521_04300)	liaF	878924..879625 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
KU521_RS04315 (KU521_04305)	-	879640..880026 (-)	387	WP_001110179.1	hypothetical protein	-
KU521_RS04320 (KU521_04310)	map	880243..881001 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
KU521_RS04325 (KU521_04315)	-	881532..882518 (+)	987	WP_000999717.1	FUSC family protein	-
KU521_RS04330 (KU521_04320)	-	882949..883362 (-)	414	WP_001557448.1	hypothetical protein	-
KU521_RS04335 (KU521_04325)	-	883391..883501 (-)	111	WP_001790257.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=584068 KU521_RS04305 WP_001017131.1 877884..878927(-) (vraS) [Staphylococcus aureus strain AC4]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=584068 KU521_RS04305 WP_001017131.1 877884..878927(-) (vraS) [Staphylococcus aureus strain AC4]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTATTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCATACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACGCTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCTCGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTTTCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGATAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1