Detailed information NTG0584002

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: KU543_RS13625
• Genome accession: NZ_CP077858
• Coordinates: 2743498..2744541 (+)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain AC6
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2738498..2749541

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
KU543_RS13595 (KU543_13530)	-	2738924..2739034 (+)	111	WP_001790257.1	hypothetical protein	-
KU543_RS13600 (KU543_13535)	-	2739063..2739476 (+)	414	WP_001557448.1	hypothetical protein	-
KU543_RS13605 (KU543_13540)	-	2739907..2740893 (-)	987	WP_000999717.1	FUSC family protein	-
KU543_RS13610 (KU543_13545)	map	2741424..2742182 (+)	759	WP_000636142.1	type I methionyl aminopeptidase	-
KU543_RS13615 (KU543_13550)	-	2742399..2742785 (+)	387	WP_001110179.1	hypothetical protein	-
KU543_RS13620 (KU543_13555)	liaF	2742800..2743501 (+)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
KU543_RS13625 (KU543_13560)	vraS	2743498..2744541 (+)	1044	WP_001017131.1	sensor histidine kinase	Regulator
KU543_RS13630 (KU543_13565)	vraR	2744531..2745160 (+)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
KU543_RS13635 (KU543_13570)	-	2745273..2746490 (-)	1218	WP_000037075.1	YihY/virulence factor BrkB family protein	-
KU543_RS13640 (KU543_13575)	-	2746768..2747043 (-)	276	WP_000428172.1	YtxH domain-containing protein	-
KU543_RS13645 (KU543_13580)	-	2747050..2747514 (-)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
KU543_RS13650 (KU543_13585)	-	2747661..2747861 (+)	201	WP_000180460.1	DUF1128 family protein	-
KU543_RS13655 (KU543_13590)	-	2747864..2749120 (+)	1257	WP_001795108.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=584002 KU543_RS13625 WP_001017131.1 2743498..2744541(+) (vraS) [Staphylococcus aureus strain AC6]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=584002 KU543_RS13625 WP_001017131.1 2743498..2744541(+) (vraS) [Staphylococcus aureus strain AC6]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTATTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCATACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACGCTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCTCGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTTTCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGATAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1