Detailed information NTG0583960

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: KU533_RS13620
• Genome accession: NZ_CP077857
• Coordinates: 2743018..2744061 (+)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain L4
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2738018..2749061

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
KU533_RS13590 (KU533_13525)	-	2738444..2738554 (+)	111	WP_001790257.1	hypothetical protein	-
KU533_RS13595 (KU533_13530)	-	2738583..2738996 (+)	414	WP_001557448.1	hypothetical protein	-
KU533_RS13600 (KU533_13535)	-	2739427..2740413 (-)	987	WP_000999717.1	FUSC family protein	-
KU533_RS13605 (KU533_13540)	map	2740944..2741702 (+)	759	WP_000636142.1	type I methionyl aminopeptidase	-
KU533_RS13610 (KU533_13545)	-	2741919..2742305 (+)	387	WP_001110179.1	hypothetical protein	-
KU533_RS13615 (KU533_13550)	liaF	2742320..2743021 (+)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
KU533_RS13620 (KU533_13555)	vraS	2743018..2744061 (+)	1044	WP_001017131.1	sensor histidine kinase	Regulator
KU533_RS13625 (KU533_13560)	vraR	2744051..2744680 (+)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
KU533_RS13630 (KU533_13565)	-	2744793..2746010 (-)	1218	WP_000037075.1	YihY/virulence factor BrkB family protein	-
KU533_RS13635 (KU533_13570)	-	2746288..2746563 (-)	276	WP_000428172.1	YtxH domain-containing protein	-
KU533_RS13640 (KU533_13575)	-	2746570..2747034 (-)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
KU533_RS13645 (KU533_13580)	-	2747181..2747381 (+)	201	WP_000180460.1	DUF1128 family protein	-
KU533_RS13650 (KU533_13585)	-	2747384..2748640 (+)	1257	WP_001795108.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=583960 KU533_RS13620 WP_001017131.1 2743018..2744061(+) (vraS) [Staphylococcus aureus strain L4]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=583960 KU533_RS13620 WP_001017131.1 2743018..2744061(+) (vraS) [Staphylococcus aureus strain L4]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTATTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCATACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACGCTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCTCGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTTTCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGATAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1