Detailed information NTG0583918

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: KU529_RS13450
• Genome accession: NZ_CP077856
• Coordinates: 2730971..2732014 (+)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain L5
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2725971..2737014

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
KU529_RS13420 (KU529_13360)	-	2726397..2726507 (+)	111	WP_001790257.1	hypothetical protein	-
KU529_RS13425 (KU529_13365)	-	2726536..2726949 (+)	414	WP_001557448.1	hypothetical protein	-
KU529_RS13430 (KU529_13370)	-	2727380..2728366 (-)	987	WP_000999717.1	FUSC family protein	-
KU529_RS13435 (KU529_13375)	map	2728897..2729655 (+)	759	WP_000636142.1	type I methionyl aminopeptidase	-
KU529_RS13440 (KU529_13380)	-	2729872..2730258 (+)	387	WP_001110179.1	hypothetical protein	-
KU529_RS13445 (KU529_13385)	liaF	2730273..2730974 (+)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
KU529_RS13450 (KU529_13390)	vraS	2730971..2732014 (+)	1044	WP_001017131.1	sensor histidine kinase	Regulator
KU529_RS13455 (KU529_13395)	vraR	2732004..2732633 (+)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
KU529_RS13460 (KU529_13400)	-	2732746..2733963 (-)	1218	WP_000037075.1	YihY/virulence factor BrkB family protein	-
KU529_RS13465 (KU529_13405)	-	2734241..2734516 (-)	276	WP_000428172.1	YtxH domain-containing protein	-
KU529_RS13470 (KU529_13410)	-	2734523..2734987 (-)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
KU529_RS13475 (KU529_13415)	-	2735134..2735334 (+)	201	WP_000180460.1	DUF1128 family protein	-
KU529_RS13480 (KU529_13420)	-	2735337..2736593 (+)	1257	WP_001795108.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=583918 KU529_RS13450 WP_001017131.1 2730971..2732014(+) (vraS) [Staphylococcus aureus strain L5]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=583918 KU529_RS13450 WP_001017131.1 2730971..2732014(+) (vraS) [Staphylococcus aureus strain L5]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTATTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCATACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACGCTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCTCGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTTTCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGATAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1