Detailed information NTG0583841

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: KU520_RS02640
• Genome accession: NZ_CP077855
• Coordinates: 488525..489568 (+)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain L6
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 483525..494568

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
KU520_RS02610 (KU520_02585)	-	483951..484061 (+)	111	WP_001790257.1	hypothetical protein	-
KU520_RS02615 (KU520_02590)	-	484090..484503 (+)	414	WP_001557448.1	hypothetical protein	-
KU520_RS02620 (KU520_02595)	-	484934..485920 (-)	987	WP_000999717.1	FUSC family protein	-
KU520_RS02625 (KU520_02600)	map	486451..487209 (+)	759	WP_000636142.1	type I methionyl aminopeptidase	-
KU520_RS02630 (KU520_02605)	-	487426..487812 (+)	387	WP_001110179.1	hypothetical protein	-
KU520_RS02635 (KU520_02610)	liaF	487827..488528 (+)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
KU520_RS02640 (KU520_02615)	vraS	488525..489568 (+)	1044	WP_001017131.1	sensor histidine kinase	Regulator
KU520_RS02645 (KU520_02620)	vraR	489558..490187 (+)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
KU520_RS02650 (KU520_02625)	-	490300..491517 (-)	1218	WP_000037075.1	YihY/virulence factor BrkB family protein	-
KU520_RS02655 (KU520_02630)	-	491795..492070 (-)	276	WP_000428172.1	YtxH domain-containing protein	-
KU520_RS02660 (KU520_02635)	-	492077..492541 (-)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
KU520_RS02665 (KU520_02640)	-	492688..492888 (+)	201	WP_000180460.1	DUF1128 family protein	-
KU520_RS02670 (KU520_02645)	-	492891..494147 (+)	1257	WP_001795108.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=583841 KU520_RS02640 WP_001017131.1 488525..489568(+) (vraS) [Staphylococcus aureus strain L6]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=583841 KU520_RS02640 WP_001017131.1 488525..489568(+) (vraS) [Staphylococcus aureus strain L6]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTATTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCATACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACGCTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCTCGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTTTCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGATAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1