Detailed information NTG0583711

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: KU516_RS00145
• Genome accession: NZ_CP077852
• Coordinates: 27063..28106 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain N6
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 22063..33106

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
KU516_RS00115 (KU516_00115)	-	22484..23740 (-)	1257	WP_001795108.1	aminopeptidase	-
KU516_RS00120 (KU516_00120)	-	23743..23943 (-)	201	WP_000180460.1	DUF1128 family protein	-
KU516_RS00125 (KU516_00125)	-	24090..24554 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
KU516_RS00130 (KU516_00130)	-	24561..24836 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
KU516_RS00135 (KU516_00135)	-	25114..26331 (+)	1218	WP_000037075.1	YihY/virulence factor BrkB family protein	-
KU516_RS00140 (KU516_00140)	vraR	26444..27073 (-)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
KU516_RS00145 (KU516_00145)	vraS	27063..28106 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
KU516_RS00150 (KU516_00150)	liaF	28103..28804 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
KU516_RS00155 (KU516_00155)	-	28819..29205 (-)	387	WP_001110179.1	hypothetical protein	-
KU516_RS00160 (KU516_00160)	map	29422..30180 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
KU516_RS00165 (KU516_00165)	-	30711..31697 (+)	987	WP_000999717.1	FUSC family protein	-
KU516_RS00170 (KU516_00170)	-	32128..32541 (-)	414	WP_001557448.1	hypothetical protein	-
KU516_RS00175 (KU516_00175)	-	32570..32680 (-)	111	WP_001790257.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=583711 KU516_RS00145 WP_001017131.1 27063..28106(-) (vraS) [Staphylococcus aureus strain N6]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=583711 KU516_RS00145 WP_001017131.1 27063..28106(-) (vraS) [Staphylococcus aureus strain N6]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTATTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCATACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACGCTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCTCGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTTTCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGATAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1