Detailed information    

insolico Bioinformatically predicted

Overview

Name   pepF   Type   Regulator
Locus tag   VB13_RS05265 Genome accession   NZ_CP077685
Coordinates   1064937..1066742 (-) Length   601 a.a.
NCBI ID   WP_009880654.1    Uniprot ID   -
Organism   Streptococcus pyogenes strain M49 591     
Function   degradation of XIP; competence shut-off (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
ICE 1044641..1091733 1064937..1066742 within 0


Gene organization within MGE regions


Location: 1044641..1091733
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  VB13_RS05185 (VB13_05345) - 1044679..1045953 (-) 1275 WP_012560787.1 polysaccharide deacetylase family protein -
  VB13_RS05190 (VB13_05350) - 1046048..1047475 (-) 1428 WP_023611678.1 NADP-dependent glyceraldehyde-3-phosphate dehydrogenase -
  VB13_RS05195 (VB13_05355) ptsP 1047660..1049393 (-) 1734 WP_002984033.1 phosphoenolpyruvate--protein phosphotransferase -
  VB13_RS05200 (VB13_05360) - 1049398..1049661 (-) 264 WP_002984031.1 phosphocarrier protein HPr -
  VB13_RS05205 (VB13_05365) - 1050054..1050272 (+) 219 WP_002989242.1 redoxin NrdH -
  VB13_RS05210 (VB13_05370) nrdE 1050292..1052451 (+) 2160 WP_012560790.1 class 1b ribonucleoside-diphosphate reductase subunit alpha -
  VB13_RS05215 (VB13_05375) nrdF 1052784..1053743 (+) 960 WP_009880539.1 class 1b ribonucleoside-diphosphate reductase subunit beta -
  VB13_RS05220 (VB13_05380) - 1053805..1055031 (+) 1227 WP_009880538.1 chloride channel protein -
  VB13_RS05225 - 1055185..1056326 (+) 1142 Protein_988 IS3 family transposase -
  VB13_RS05230 (VB13_05400) - 1056419..1057114 (-) 696 WP_002995750.1 CPBP family intramembrane glutamic endopeptidase -
  VB13_RS05235 (VB13_05405) - 1057133..1057894 (-) 762 WP_002995753.1 DUF3169 family protein -
  VB13_RS05240 (VB13_05410) - 1057891..1058106 (-) 216 WP_002989220.1 helix-turn-helix transcriptional regulator -
  VB13_RS05245 (VB13_05415) alaS 1058467..1061085 (-) 2619 WP_219050250.1 alanine--tRNA ligase -
  VB13_RS05250 (VB13_05420) prsA 1061472..1062527 (-) 1056 WP_002984003.1 peptidylprolyl isomerase PrsA -
  VB13_RS05255 (VB13_05425) - 1062590..1063297 (-) 708 WP_219050252.1 O-methyltransferase -
  VB13_RS05260 (VB13_05430) - 1063363..1064559 (-) 1197 WP_002995765.1 OFA family MFS transporter -
  VB13_RS05265 (VB13_05435) pepF 1064937..1066742 (-) 1806 WP_009880654.1 oligoendopeptidase F Regulator
  VB13_RS05270 (VB13_05440) - 1066755..1067717 (-) 963 WP_009880653.1 competence protein CoiA -
  VB13_RS05275 (VB13_05445) - 1068014..1068730 (-) 717 WP_009880652.1 pseudouridine synthase -
  VB13_RS05280 (VB13_05450) nagB 1068849..1069553 (-) 705 WP_009880651.1 glucosamine-6-phosphate deaminase -
  VB13_RS05285 (VB13_05455) queA 1069755..1070783 (+) 1029 WP_002995782.1 tRNA preQ1(34) S-adenosylmethionine ribosyltransferase-isomerase QueA -
  VB13_RS05290 (VB13_05460) - 1070790..1072010 (+) 1221 WP_012560799.1 DUF3114 domain-containing protein -
  VB13_RS05295 (VB13_05465) - 1072124..1072714 (-) 591 WP_012560800.1 serine hydrolase -
  VB13_RS05300 (VB13_05470) - 1072711..1072959 (-) 249 WP_009881160.1 hypothetical protein -
  VB13_RS05305 (VB13_05475) - 1072944..1073171 (-) 228 WP_011054657.1 hypothetical protein -
  VB13_RS05310 (VB13_05480) sodA 1073333..1073938 (-) 606 WP_002983977.1 superoxide dismutase SodA -
  VB13_RS05315 (VB13_05485) holA 1074035..1075075 (-) 1041 WP_011054659.1 DNA polymerase III subunit delta -
  VB13_RS05320 (VB13_05490) - 1075146..1077389 (-) 2244 WP_009880877.1 DNA internalization-related competence protein ComEC/Rec2 -
  VB13_RS05325 (VB13_05495) - 1077370..1078032 (-) 663 WP_012560803.1 ComEA family DNA-binding protein -
  VB13_RS05330 (VB13_05500) - 1078232..1078972 (-) 741 WP_012560804.1 1-acyl-sn-glycerol-3-phosphate acyltransferase -
  VB13_RS05335 (VB13_05505) - 1079090..1079866 (+) 777 WP_079891413.1 tRNA1(Val) (adenine(37)-N6)-methyltransferase -
  VB13_RS05340 (VB13_05510) - 1079856..1080134 (+) 279 WP_002989164.1 GIY-YIG nuclease family protein -
  VB13_RS05345 (VB13_05515) - 1080158..1082158 (-) 2001 WP_012560805.1 potassium transporter Kup -
  VB13_RS05350 (VB13_05520) - 1082286..1083905 (-) 1620 WP_002989158.1 DEAD/DEAH box helicase -
  VB13_RS05355 (VB13_05525) - 1084212..1085756 (-) 1545 WP_012560807.1 peptide chain release factor 3 -
  VB13_RS05360 (VB13_05530) - 1086004..1086699 (-) 696 WP_002983946.1 TIGR02206 family membrane protein -
  VB13_RS05365 (VB13_05535) murF 1086779..1088170 (-) 1392 WP_012560808.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
  VB13_RS05370 (VB13_05540) - 1088361..1089407 (-) 1047 WP_002989146.1 D-alanine--D-alanine ligase -
  VB13_RS05375 (VB13_05545) recR 1089508..1090104 (-) 597 WP_002983939.1 recombination mediator RecR -
  VB13_RS08790 - 1090151..1090342 (-) 192 WP_012560809.1 hypothetical protein -
  VB13_RS05380 (VB13_05550) - 1090902..1091681 (-) 780 WP_014407680.1 formate/nitrite transporter family protein -

Sequence

Protein


Download         Length: 601 a.a.        Molecular weight: 69434.51 Da        Isoelectric Point: 4.8042

>NTDB_id=582242 VB13_RS05265 WP_009880654.1 1064937..1066742(-) (pepF) [Streptococcus pyogenes strain M49 591]
MTDNRSHLEEKYTWDLSTIFATDKDWEAEVSDLATEVEASKGFAGHLLDSSANLLKVTKTYLELARRVEKVYVYAHMKND
QDTTVAKYQEYQAKASGLYAKFSEVFSFYDPEVMMLHQEDYQAFLTETPELKVYNHFFDKLFQAREHVLSQAEEELLAGA
QEIFNGAEETFSILDNADIVFPIVRNDKGENIELTHGNFISLMESKDRSVRQAAYEAMYSTYEQFQHTYAKTLQTNVKVQ
NYKARVHKYDSARQAAMAANFIPEAVYDTLLETVNKHLPLLHRYLKLRQEVLGLDDLKMYDVYTPLSETDLAIGYDEALE
KAEKVLAVFGKDYADRVHRAFTERWIDVHVNKGKRSGAYSGGSYDTNAFMLLNWQDTLDNLYTLVHETGHSLHSTFTRET
QPYVYGDYSIFLAEIASTTNENIMTEALLNEVQDEKERFAILNHYLDGFRGTVFRQTQFAEFEHAIHQADQKGEVLTSEY
LNQLYADLNEKYYGLSKKDNHFIQYEWARIPHFYYNYYVYQYATGFAAASYLADKIVHGTQDDIDYYLAYLKSGNSDYPL
EVIAKAGVDMAKGDYLEAAFKVFDERLTELEVLVSKGIHKS

Nucleotide


Download         Length: 1806 bp        

>NTDB_id=582242 VB13_RS05265 WP_009880654.1 1064937..1066742(-) (pepF) [Streptococcus pyogenes strain M49 591]
ATGACTGATAATCGCAGCCATTTAGAAGAAAAATACACTTGGGATTTGAGCACTATTTTTGCAACAGATAAGGATTGGGA
AGCTGAAGTCAGTGACTTAGCTACTGAAGTTGAGGCATCTAAAGGTTTTGCTGGTCATTTGCTGGATTCTAGTGCTAATT
TGTTAAAGGTTACAAAAACATATTTAGAATTGGCTCGTCGTGTGGAGAAAGTCTATGTTTATGCTCACATGAAAAATGAC
CAAGACACTACTGTTGCCAAGTATCAAGAATACCAAGCTAAGGCTTCAGGCTTGTATGCAAAGTTTAGCGAAGTCTTTTC
ATTCTATGATCCAGAAGTGATGATGCTTCATCAAGAAGACTATCAGGCTTTCCTTACTGAAACCCCTGAGTTGAAAGTGT
ACAACCATTTCTTTGACAAATTATTCCAAGCCCGCGAACATGTTCTTAGTCAAGCAGAAGAGGAATTATTAGCAGGAGCT
CAAGAAATTTTCAATGGTGCGGAAGAAACCTTTAGTATTCTTGATAACGCTGACATTGTTTTCCCGATAGTCAGAAATGA
TAAAGGTGAAAACATTGAATTAACCCATGGTAACTTCATTAGCCTAATGGAATCTAAGGACCGTAGCGTTCGCCAAGCTG
CTTATGAAGCCATGTATAGTACTTATGAACAGTTCCAACATACTTACGCTAAAACCTTGCAAACCAATGTGAAAGTGCAA
AACTATAAGGCGCGTGTTCATAAATACGATTCAGCACGTCAAGCTGCCATGGCTGCTAACTTTATTCCAGAAGCTGTTTA
CGACACTTTATTAGAAACGGTTAACAAACATTTACCACTCTTACACCGTTATTTGAAATTGCGTCAAGAGGTTCTTGGTT
TAGACGATTTGAAGATGTATGATGTTTACACACCATTATCTGAAACAGATTTAGCCATTGGTTATGATGAGGCTTTGGAA
AAGGCTGAGAAGGTTTTGGCTGTTTTTGGTAAGGATTACGCAGATCGTGTACATCGTGCTTTTACCGAACGTTGGATTGA
TGTTCACGTCAATAAAGGGAAGCGCTCTGGGGCTTATTCAGGTGGTTCCTATGATACCAATGCCTTCATGCTGTTGAACT
GGCAAGATACACTTGATAATCTTTACACACTTGTCCACGAAACAGGCCACAGTTTGCATTCTACTTTCACTCGTGAAACA
CAGCCTTATGTGTATGGGGATTATAGTATCTTCTTGGCAGAAATTGCATCCACAACGAATGAAAACATCATGACAGAAGC
TCTCTTAAATGAGGTTCAAGATGAGAAAGAACGCTTTGCCATTTTAAACCATTACCTCGATGGTTTCCGTGGAACAGTTT
TCCGTCAAACCCAATTTGCTGAGTTTGAACATGCCATTCATCAAGCTGATCAAAAAGGAGAAGTGTTAACAAGTGAATAC
CTTAACCAGCTATACGCTGATTTAAATGAAAAATATTATGGTTTAAGTAAAAAAGATAATCATTTTATTCAGTATGAATG
GGCACGTATTCCTCATTTCTATTACAATTATTATGTTTACCAATATGCAACAGGTTTTGCAGCTGCAAGCTATTTAGCGG
ATAAGATTGTGCATGGCACACAAGATGATATCGATTATTACTTGGCCTACCTCAAGTCAGGAAATTCTGATTACCCACTT
GAAGTGATTGCTAAAGCAGGCGTTGATATGGCAAAAGGTGATTATTTGGAAGCCGCCTTTAAAGTCTTTGACGAACGTCT
AACAGAACTTGAAGTACTCGTGTCCAAAGGCATACACAAAAGCTAA

Domains

Predicted by InterproScan.

Peptidase family M3 (Peptidase_M3)

(202-581)

Oligopeptidase F (Peptidase_M3_N)

(112-181)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  pepF Streptococcus salivarius strain HSISS4

70.549

100

0.705