Detailed information    

insolico Bioinformatically predicted

Overview

Name   comD/comD1   Type   Regulator
Locus tag   SPN994039_RS10885 Genome accession   NC_021005
Coordinates   2022065..2023390 (-) Length   441 a.a.
NCBI ID   WP_014632435.1    Uniprot ID   -
Organism   Streptococcus pneumoniae SPN994039     
Function   phosphorylation of ComE (predicted from homology)   
Competence regulation

Genomic Context

Location: 2017065..2028390
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SPN994039_RS13280 - 2018751..2020425 (-) 1675 Protein_2048 YhgE/Pip domain-containing protein -
  SPN994039_RS10865 (SPN994039_19690) - 2020532..2021074 (+) 543 WP_001158255.1 TetR/AcrR family transcriptional regulator -
  SPN994039_RS10880 (SPN994039_19700) comE 2021316..2022068 (-) 753 WP_000866065.1 competence system response regulator transcription factor ComE Regulator
  SPN994039_RS10885 (SPN994039_19710) comD/comD1 2022065..2023390 (-) 1326 WP_014632435.1 competence system sensor histidine kinase ComD Regulator
  SPN994039_RS10890 (SPN994039_19720) comC/comC1 2023411..2023536 (-) 126 WP_000799689.1 competence-stimulating peptide ComC Regulator
  SPN994039_RS10900 (SPN994039_19730) rlmH 2023819..2024298 (-) 480 WP_000695929.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  SPN994039_RS10905 (SPN994039_19740) htrA 2024481..2025662 (+) 1182 WP_000681597.1 trypsin-like peptidase domain-containing protein Regulator
  SPN994039_RS10910 (SPN994039_19750) spo0J 2025720..2026478 (+) 759 WP_000410383.1 ParB/RepB/Spo0J family partition protein Regulator

Sequence

Protein


Download         Length: 441 a.a.        Molecular weight: 51197.70 Da        Isoelectric Point: 6.9339

>NTDB_id=57985 SPN994039_RS10885 WP_014632435.1 2022065..2023390(-) (comD/comD1) [Streptococcus pneumoniae SPN994039]
MDLFGFGTVIVHFLIISHSYHLICKGQINRKELFVFGAYTLLTEIVFDFPLYILYLDGLGIATFLFPLGLYSYFRWIKQY
ERDRGLFLSLLLSLLYESTHNFLPVTFSSITGDNFVLQYHFPFFFVVTVLTYFVTLKIIYYFHLELAYFDKDYLYPFLKK
VFFALLLLHIVSFVSDMVSTIKHLNSFGSILSSIVFISLLLTFFAMNSHKVQMEKEIALKQKKFEQKHLQNYTDEIVGLY
NEIRGFRHDYAGMLVSMQMAIDSGNLQEIDRIYNEVLVKANHKLRSDKYTYFDLNNIEDSALRSLVAQSIVYARNNGVEF
TLEVKDTITKLPIELLDLVRIMSVLLNNAVEGSADSYKKQMEVAVIKMETETVIVIQNSCKMTMTPSGDLFALGFSTKGR
NRGVGLNNVKELLDKYNNIILETEMEGSTFRQIIRFKREFE

Nucleotide


Download         Length: 1326 bp        

>NTDB_id=57985 SPN994039_RS10885 WP_014632435.1 2022065..2023390(-) (comD/comD1) [Streptococcus pneumoniae SPN994039]
ATGGATTTATTTGGATTTGGGACAGTTATTGTTCATTTTTTAATTATTAGTCACAGCTACCATTTAATTTGTAAAGGTCA
AATAAATAGAAAAGAATTATTCGTTTTTGGTGCTTATACATTACTAACAGAAATAGTATTTGATTTTCCCTTATATATTC
TATATTTAGATGGGTTAGGGATTGCAACATTTTTATTTCCTTTGGGCCTATATTCCTATTTTCGATGGATAAAACAGTAT
GAGAGGGATAGAGGACTATTCCTAAGTTTACTACTATCTCTTTTATATGAGAGCACTCATAACTTTCTGCCCGTAACTTT
CTCCTCTATAACAGGAGATAATTTTGTTTTACAATATCATTTCCCATTCTTTTTCGTTGTGACGGTGTTGACCTATTTTG
TTACATTAAAAATCATTTATTATTTCCATTTGGAACTAGCCTATTTTGACAAGGACTACCTTTATCCTTTCTTGAAAAAA
GTATTTTTTGCTTTACTATTGCTACATATTGTATCTTTCGTTTCAGATATGGTAAGTACGATTAAACATTTGAATAGTTT
TGGAAGTATTTTGTCATCTATTGTCTTTATCTCTCTCCTTTTGACCTTCTTTGCAATGAATTCTCATAAAGTTCAAATGG
AGAAAGAGATTGCTTTGAAGCAGAAGAAATTTGAACAGAAACATTTACAGAATTACACAGATGAAATTGTTGGTCTGTAT
AATGAAATCCGTGGTTTTCGACATGATTATGCTGGAATGCTTGTCAGCATGCAGATGGCAATTGACAGTGGTAATTTACA
GGAAATTGACAGAATTTACAATGAAGTTTTAGTCAAAGCAAATCATAAATTGCGTTCAGATAAGTACACTTACTTTGATT
TGAACAACATAGAAGACTCAGCTTTACGAAGTTTGGTTGCTCAGTCAATTGTCTATGCTCGAAATAATGGTGTAGAGTTT
ACACTGGAAGTAAAAGATACGATTACCAAGCTTCCAATTGAACTATTGGATTTGGTTCGTATCATGAGCGTTTTATTGAA
TAATGCTGTCGAAGGATCGGCTGATAGCTATAAAAAGCAGATGGAAGTAGCAGTTATTAAGATGGAAACTGAAACAGTTA
TTGTGATTCAGAATTCATGTAAAATGACGATGACTCCTTCAGGAGATCTATTTGCCTTAGGATTCTCCACTAAGGGAAGA
AATCGCGGAGTCGGATTAAATAATGTGAAAGAACTACTAGATAAGTACAACAATATTATTTTAGAAACAGAGATGGAAGG
CAGTACATTTAGACAAATCATTAGATTTAAGAGGGAATTTGAATGA

Domains

Predicted by InterproScan.

GHKL domain (HATPase_c_5)

(334-434)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comD/comD1 Streptococcus pneumoniae Rx1

98.639

100

0.986
  comD/comD1 Streptococcus pneumoniae D39

98.639

100

0.986
  comD/comD1 Streptococcus pneumoniae R6

98.639

100

0.986
  comD/comD2 Streptococcus pneumoniae TIGR4

96.372

100

0.964
  comD Streptococcus mitis SK321

92.517

100

0.925
  comD Streptococcus mitis NCTC 12261

86.395

100

0.864
  comD/comD1 Streptococcus gordonii str. Challis substr. CH1

49.202

85.261

0.42
  comD/comD2 Streptococcus gordonii strain NCTC7865

48.936

85.261

0.417

Multiple sequence alignment