Detailed information    

insolico Bioinformatically predicted

Overview

Name   clpC   Type   Regulator
Locus tag   SPYKS030_RS06710 Genome accession   NZ_AP018337
Coordinates   1234304..1236403 (+) Length   699 a.a.
NCBI ID   WP_010922175.1    Uniprot ID   A0A0H2UU50
Organism   Streptococcus pyogenes strain KS030     
Function   degradation of ComX (predicted from homology)   
Competence regulation

Genomic Context

Location: 1229304..1241403
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SPYKS030_RS06685 (SPYKS030_12570) deoD 1229325..1230038 (-) 714 WP_002990147.1 purine-nucleoside phosphorylase -
  SPYKS030_RS06690 (SPYKS030_12580) - 1230701..1231510 (-) 810 WP_010922178.1 purine-nucleoside phosphorylase -
  SPYKS030_RS06695 (SPYKS030_12590) arsC 1231494..1231934 (-) 441 WP_010922177.1 arsenate reductase (glutaredoxin) -
  SPYKS030_RS06700 (SPYKS030_12600) - 1231953..1233164 (-) 1212 WP_002994004.1 phosphopentomutase -
  SPYKS030_RS06705 (SPYKS030_12610) rpiA 1233241..1233924 (-) 684 WP_010922176.1 ribose-5-phosphate isomerase RpiA -
  SPYKS030_RS06710 (SPYKS030_12620) clpC 1234304..1236403 (+) 2100 WP_010922175.1 AAA family ATPase Regulator
  SPYKS030_RS06715 (SPYKS030_12630) - 1236456..1237202 (-) 747 WP_011054380.1 hypothetical protein -
  SPYKS030_RS06720 (SPYKS030_12640) yihA 1237350..1237949 (-) 600 WP_011054379.1 ribosome biogenesis GTP-binding protein YihA/YsxC -
  SPYKS030_RS06725 (SPYKS030_12650) clpX 1237959..1239188 (-) 1230 WP_002984948.1 ATP-dependent Clp protease ATP-binding subunit ClpX Regulator
  SPYKS030_RS06730 (SPYKS030_12660) - 1239318..1239488 (-) 171 WP_002984950.1 hypothetical protein -
  SPYKS030_RS06735 (SPYKS030_12670) - 1239508..1240005 (-) 498 WP_002984955.1 dihydrofolate reductase -
  SPYKS030_RS06740 (SPYKS030_12680) - 1240085..1240924 (-) 840 WP_010922172.1 thymidylate synthase -

Sequence

Protein


Download         Length: 699 a.a.        Molecular weight: 77347.42 Da        Isoelectric Point: 5.6670

>NTDB_id=57985 SPYKS030_RS06710 WP_010922175.1 1234304..1236403(+) (clpC) [Streptococcus pyogenes strain KS030]
MTHFSGKDPFVNMDDIFNQLMANMGGYRSENPRYLVNGREITPEEFQHYRQTGQLPVATTKATNSQMLTPKADSVLTQLG
TNLTQEARQGHLDPVIGRNKEIQDTAEILARRTKNNPVLVGDAGVGKTAVIEGLAQAIVNGDVPAAIKNKEIVSIDISSL
EAGTQYRGSFEETIQNLIQEVKEAGNIILFFDEIHQIVGAGATSSDSGSKGLADILKPALSRGELTLIGATTQDEYRNTI
LKNAALARRFNEVKVNAPSAEDTFHILMGIRNLYEQHHHITLPDNVLKAAVDYSIQYIPQRSLPDKAIDLLDMTAAHLAA
QHPVTDLKTLETEIAKQKESQEKAVAKEDFEKALAAKTRIETLQKQIEQHNQSQNVTATVNDIAESVERLTGIPVSNMGT
NDLERLKGISSRLKSHVIGQDEAVAAVARAIRRNRAGFDDGKRPIGSFLFVGPTGVGKTELAKQLALDLFGSKDAIIRLD
MSEYNDRTAVSKLIGTTAGYVGYDDNNNTLTERVRRNPYAIVLLDEIEKADPQIITLLLQVLDDGRLTDGQGNTINFKNT
VIIATSNAGFGQQDTETSESNIMDRIAPYFRPEFLNRFNSIIKFNHLQKESLEEIVDLMLAEVNQTTAKKGISLTITDDA
KAHLIDLGYNHAMGARPLRRIIEQEIRDRITDYYLDHPEVKKLQAILKEGQLVIRQNDQ

Nucleotide


Download         Length: 2100 bp        

>NTDB_id=57985 SPYKS030_RS06710 WP_010922175.1 1234304..1236403(+) (clpC) [Streptococcus pyogenes strain KS030]
ATGACACATTTTTCTGGTAAAGATCCTTTTGTAAATATGGATGATATTTTCAATCAATTAATGGCAAACATGGGTGGTTA
TCGTAGCGAAAATCCCCGCTATCTCGTTAACGGTCGCGAAATAACTCCCGAAGAATTCCAACACTATCGTCAAACAGGAC
AACTCCCTGTAGCGACAACCAAAGCAACAAATTCTCAAATGTTAACACCTAAAGCTGATAGTGTATTGACTCAACTCGGA
ACTAACTTAACACAAGAAGCTCGTCAAGGGCATCTTGACCCCGTCATTGGTCGTAACAAAGAAATTCAAGATACCGCTGA
AATCTTGGCACGACGAACTAAAAATAATCCTGTCCTTGTCGGAGATGCTGGTGTCGGTAAAACTGCAGTCATTGAAGGTT
TAGCTCAAGCCATTGTTAATGGAGATGTCCCAGCTGCTATTAAAAACAAGGAAATCGTATCAATTGATATTTCTAGTCTT
GAAGCTGGTACACAGTATCGTGGTTCCTTTGAAGAGACCATTCAAAACTTGATTCAAGAAGTAAAAGAAGCTGGGAATAT
CATCTTATTTTTTGATGAAATTCATCAAATAGTTGGTGCTGGTGCCACAAGCAGTGATTCAGGCTCAAAGGGACTTGCAG
ATATTCTTAAACCAGCCTTGTCACGAGGAGAATTAACACTGATTGGTGCTACTACTCAAGACGAATACCGCAATACTATT
TTAAAAAATGCTGCTCTTGCTCGTCGCTTTAATGAAGTTAAAGTGAATGCACCATCAGCTGAAGATACTTTTCACATTTT
AATGGGTATTCGTAATCTTTATGAACAACACCACCATATTACCCTTCCTGATAATGTTCTAAAAGCTGCTGTTGATTATT
CTATTCAATACATCCCACAGCGTAGCCTGCCAGATAAAGCAATTGACTTACTGGATATGACAGCTGCTCATTTAGCTGCG
CAACACCCGGTCACTGACTTAAAAACACTCGAAACTGAAATAGCTAAACAAAAAGAGAGTCAAGAAAAAGCTGTCGCCAA
AGAAGACTTTGAAAAAGCTTTAGCAGCAAAAACACGGATTGAAACATTACAAAAGCAAATTGAGCAACATAACCAAAGCC
AAAATGTCACTGCTACAGTCAATGATATCGCAGAGTCTGTAGAGCGCTTAACTGGTATTCCTGTCTCTAACATGGGGACT
AATGATTTAGAAAGGCTCAAAGGAATTAGCAGCCGCTTAAAAAGCCATGTCATCGGACAAGATGAGGCTGTCGCAGCAGT
AGCACGTGCTATTCGACGAAATCGGGCAGGTTTTGATGATGGTAAACGTCCAATAGGTTCTTTCCTTTTTGTGGGTCCAA
CTGGTGTTGGTAAAACAGAGTTAGCTAAACAATTAGCACTTGATTTATTTGGTTCCAAAGATGCTATTATTCGACTTGAT
ATGTCCGAATATAACGATCGCACTGCTGTGTCAAAATTGATTGGGACAACGGCTGGTTATGTTGGCTACGATGATAATAA
TAATACCCTAACTGAGCGTGTTCGTCGTAACCCTTATGCTATTGTCTTACTAGATGAAATTGAAAAAGCTGATCCTCAAA
TTATTACACTTCTTCTACAAGTATTAGATGATGGACGATTGACAGATGGACAAGGAAATACTATTAACTTTAAAAATACC
GTTATTATTGCTACATCAAATGCCGGTTTTGGCCAACAAGATACGGAAACTTCTGAGTCTAACATTATGGATCGCATTGC
ACCTTATTTCAGACCAGAGTTTTTGAACCGTTTTAATAGTATCATTAAATTTAATCATCTGCAAAAAGAAAGTTTAGAAG
AAATTGTTGATTTAATGCTAGCTGAAGTAAATCAAACCACCGCAAAAAAAGGTATTAGTTTAACGATTACTGATGACGCT
AAAGCTCATTTGATAGATTTAGGGTACAATCACGCTATGGGAGCTCGTCCATTACGACGTATTATCGAACAGGAAATTCG
TGACCGTATAACTGATTATTATCTTGACCATCCAGAAGTCAAAAAACTTCAGGCAATCCTAAAAGAAGGACAACTAGTGA
TTAGGCAAAACGATCAGTAA

Domains

Predicted by InterProScan.

C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small)

(607-678)

ATPase family associated with various cellular activities (AAA) (AAA)

(118-250)

AAA domain (Cdc48 subfamily) (AAA_2)

(443-600)

AAA lid domain (AAA_lid_9)

(259-353)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A0H2UU50

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  clpC Lactococcus lactis subsp. cremoris KW2

46.942

100

0.472
  clpE Streptococcus mutans UA159

49.068

92.132

0.452
  clpE Streptococcus pneumoniae TIGR4

49.278

89.127

0.439
  clpE Streptococcus pneumoniae Rx1

49.278

89.127

0.439
  clpE Streptococcus pneumoniae D39

49.278

89.127

0.439
  clpE Streptococcus pneumoniae R6

49.278

89.127

0.439
  clpC Bacillus subtilis subsp. subtilis str. 168

44.962

95.136

0.428
  clpC Streptococcus pneumoniae Rx1

42.025

93.276

0.392
  clpC Streptococcus pneumoniae D39

42.025

93.276

0.392
  clpC Streptococcus thermophilus LMD-9

42.947

91.273

0.392
  clpC Streptococcus thermophilus LMG 18311

42.79

91.273

0.391
  clpC Lactococcus lactis subsp. lactis strain DGCC12653

41.501

93.419

0.388
  clpC Streptococcus pneumoniae TIGR4

43.016

90.129

0.388
  clpC Streptococcus mutans UA159

41.875

91.559

0.383

Multiple sequence alignment