Detailed information    

insolico Bioinformatically predicted

Overview

Name   comE/blpR   Type   Regulator
Locus tag   SPN994039_RS02575 Genome accession   NC_021005
Coordinates   478795..479532 (+) Length   245 a.a.
NCBI ID   WP_001219127.1    Uniprot ID   A0A4J1ZS24
Organism   Streptococcus pneumoniae SPN994039     
Function   activate transcription of early competence genes; regulation of comX expression (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Prophage 475127..484671 478795..479532 within 0


Gene organization within MGE regions


Location: 475127..484671
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SPN994039_RS02545 (SPN994039_04720) - 475127..475414 (-) 288 WP_000777760.1 hypothetical protein -
  SPN994039_RS02550 (SPN994039_04730) - 475424..475834 (-) 411 WP_001278301.1 HIT family protein -
  SPN994039_RS02555 (SPN994039_04740) pptA 475902..476633 (+) 732 WP_000889923.1 ABC transporter ATP-binding protein Regulator
  SPN994039_RS02560 (SPN994039_04750) - 476630..477679 (+) 1050 WP_000653752.1 ABC transporter permease -
  SPN994039_RS02565 (SPN994039_04760) - 477847..478176 (-) 330 WP_000132570.1 hypothetical protein -
  SPN994039_RS02570 (SPN994039_04770) - 478452..478790 (+) 339 WP_000682119.1 LytTR family DNA-binding domain-containing protein -
  SPN994039_RS02575 (SPN994039_04780) comE/blpR 478795..479532 (+) 738 WP_001219127.1 response regulator transcription factor Regulator
  SPN994039_RS02580 (SPN994039_04790) - 479546..480886 (+) 1341 WP_001017622.1 sensor histidine kinase -
  SPN994039_RS02585 (SPN994039_04800) blpC 480928..481083 (-) 156 WP_000358813.1 quorum-sensing system pheromone BlpC -
  SPN994039_RS02590 (SPN994039_04810) - 481140..482501 (-) 1362 WP_001069092.1 bacteriocin secretion accessory protein -
  SPN994039_RS13305 comA/nlmT 482512..483000 (-) 489 WP_307774349.1 ATP-binding cassette domain-containing protein Regulator
  SPN994039_RS13310 comA/nlmT 482984..483424 (-) 441 WP_001808911.1 ATP-binding cassette domain-containing protein Regulator
  SPN994039_RS13315 comA/nlmT 483414..484139 (-) 726 WP_167750760.1 ABC transporter transmembrane domain-containing protein Regulator
  SPN994039_RS13320 (SPN994039_04830) comA/nlmT 484084..484671 (-) 588 WP_000205166.1 cysteine peptidase family C39 domain-containing protein Regulator

Sequence

Protein


Download         Length: 245 a.a.        Molecular weight: 28683.81 Da        Isoelectric Point: 6.0431

>NTDB_id=57926 SPN994039_RS02575 WP_001219127.1 478795..479532(+) (comE/blpR) [Streptococcus pneumoniae SPN994039]
MRIFVLEDDFSQQTRIETTIEKLLKAHHIIPSSFEVFGKPDQLLAEVHEKGAHQLFFLDIEIRNEEMKGLEVARKIREQD
PYALIVFVTTHSEFMPLSFRYQVSALDYIDKALSAEEFESRIETALLYANSQDSKSLAEDCFYFKSKFAQFQYPFKEVYY
LETSPRPHRVILYTKTDRLEFTASLEEVFKQEPSLLQCHRSFLINPANVVHLDKKEKLLFFPNGGSCLIARYKVREVSEA
INNLH

Nucleotide


Download         Length: 738 bp        

>NTDB_id=57926 SPN994039_RS02575 WP_001219127.1 478795..479532(+) (comE/blpR) [Streptococcus pneumoniae SPN994039]
ATGAGAATATTTGTTTTAGAAGATGATTTTTCCCAACAGACTAGAATTGAAACGACGATTGAGAAACTTTTGAAAGCACA
TCATATCATTCCTAGCTCTTTTGAGGTATTTGGCAAGCCGGACCAACTGCTGGCAGAGGTACATGAGAAGGGGGCCCATC
AGCTATTCTTTTTGGATATTGAGATTCGAAATGAAGAGATGAAGGGACTGGAAGTAGCTAGAAAGATTCGGGAACAAGAC
CCTTATGCCCTAATCGTCTTTGTGACGACTCACTCGGAGTTTATGCCTCTGTCCTTTCGCTACCAAGTGTCAGCTTTGGA
CTACATTGATAAGGCCCTTTCGGCAGAGGAGTTTGAATCTCGTATCGAGACAGCCCTCCTCTATGCCAATAGTCAAGATA
GTAAAAGTCTGGCGGAAGATTGCTTTTACTTTAAATCAAAATTTGCCCAATTCCAATATCCTTTCAAAGAGGTTTACTAT
CTCGAAACATCCCCAAGACCCCATCGTGTTATTCTCTATACCAAGACGGACAGGCTAGAATTTACGGCGAGTTTAGAGGA
GGTTTTTAAGCAGGAACCCAGTCTCTTGCAGTGCCATCGCTCTTTTCTCATCAATCCTGCAAATGTGGTGCATTTGGATA
AGAAAGAAAAACTCCTTTTCTTTCCCAATGGTGGAAGCTGTCTGATCGCGCGTTATAAGGTCAGGGAAGTGTCTGAGGCT
ATTAATAACTTACACTGA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(3-122)

LytTr DNA-binding domain (LytTR)

(151-241)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A4J1ZS24

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comE/blpR Streptococcus mutans UA159

53.498

99.184

0.531
  comE/comE1 Streptococcus equinus JB1

43.46

96.735

0.42
  comE/comE2 Streptococcus equinus JB1

38.843

98.776

0.384

Multiple sequence alignment