Detailed information NTG0578342

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: KQY23_RS09575
• Genome accession: NZ_CP076823
• Coordinates: 1960699..1961742 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain ST59
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1955699..1966742

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
KQY23_RS09545 (KQY23_09545)	-	1956120..1957376 (-)	1257	WP_078065149.1	aminopeptidase	-
KQY23_RS09550 (KQY23_09550)	-	1957379..1957579 (-)	201	WP_000180460.1	DUF1128 family protein	-
KQY23_RS09555 (KQY23_09555)	-	1957726..1958190 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
KQY23_RS09560 (KQY23_09560)	-	1958197..1958472 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
KQY23_RS09565 (KQY23_09565)	-	1958750..1959967 (+)	1218	WP_000037087.1	YihY/virulence factor BrkB family protein	-
KQY23_RS09570 (KQY23_09570)	vraR	1960080..1960709 (-)	630	WP_000153526.1	two-component system response regulator VraR	Regulator
KQY23_RS09575 (KQY23_09575)	vraS	1960699..1961742 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
KQY23_RS09580 (KQY23_09580)	liaF	1961739..1962440 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
KQY23_RS09585 (KQY23_09585)	-	1962455..1962841 (-)	387	WP_001110179.1	hypothetical protein	-
KQY23_RS09590 (KQY23_09590)	map	1963058..1963816 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
KQY23_RS09595 (KQY23_09595)	-	1964345..1965331 (+)	987	WP_000999708.1	aromatic acid exporter family protein	-
KQY23_RS09600 (KQY23_09600)	-	1965764..1966177 (-)	414	WP_025174552.1	hypothetical protein	-
KQY23_RS09605 (KQY23_09605)	-	1966206..1966316 (-)	111	WP_001790257.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=578342 KQY23_RS09575 WP_001017131.1 1960699..1961742(-) (vraS) [Staphylococcus aureus strain ST59]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=578342 KQY23_RS09575 WP_001017131.1 1960699..1961742(-) (vraS) [Staphylococcus aureus strain ST59]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGTATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAACGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGATCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1