Detailed information NTG0057230

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: SAI2T2_RS09525
• Genome accession: NC_020564
• Coordinates: 1925742..1926785 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus subsp. aureus ST228
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1920742..1931785

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SAI2T2_RS09495 (SAI2T2_1014240)	-	1921163..1922419 (-)	1257	WP_001795108.1	aminopeptidase	-
SAI2T2_RS09500	-	1922422..1922622 (-)	201	WP_078066076.1	DUF1128 family protein	-
SAI2T2_RS09505 (SAI2T2_1014250)	-	1922769..1923233 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
SAI2T2_RS09510	-	1923240..1923515 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
SAI2T2_RS09515 (SAI2T2_1014260)	-	1923793..1925010 (+)	1218	WP_000037075.1	YihY/virulence factor BrkB family protein	-
SAI2T2_RS09520 (SAI2T2_1014270)	vraR	1925123..1925752 (-)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
SAI2T2_RS09525 (SAI2T2_1014280)	vraS	1925742..1926785 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
SAI2T2_RS09530 (SAI2T2_1014290)	liaF	1926782..1927483 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
SAI2T2_RS09535	-	1927498..1927884 (-)	387	WP_001110179.1	hypothetical protein	-
SAI2T2_RS09540 (SAI2T2_1014300)	map	1928101..1928859 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
SAI2T2_RS09550 (SAI2T2_1014310)	-	1929390..1930376 (+)	987	WP_000999717.1	aromatic acid exporter family protein	-
SAI2T2_RS09555 (SAI2T2_1014320)	-	1930807..1931220 (-)	414	WP_001557448.1	hypothetical protein	-
SAI2T2_RS14830	-	1931249..1931359 (-)	111	WP_001790257.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=57230 SAI2T2_RS09525 WP_001017131.1 1925742..1926785(-) (vraS) [Staphylococcus aureus subsp. aureus ST228]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=57230 SAI2T2_RS09525 WP_001017131.1 1925742..1926785(-) (vraS) [Staphylococcus aureus subsp. aureus ST228]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTATTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCATACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCTCGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTTTCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGATAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1