Detailed information NTG0571889

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: KMZ21_RS09215
• Genome accession: NZ_CP076105
• Coordinates: 1892048..1893091 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus subsp. aureus RN4220
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1887048..1898091

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
KMZ21_RS09185 (KMZ21_09185)	-	1887466..1888722 (-)	1257	WP_001795438.1	aminopeptidase	-
KMZ21_RS09190 (KMZ21_09190)	-	1888725..1888925 (-)	201	WP_000180461.1	DUF1128 family protein	-
KMZ21_RS09195 (KMZ21_09195)	-	1889072..1889536 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
KMZ21_RS09200 (KMZ21_09200)	-	1889543..1889818 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
KMZ21_RS09205 (KMZ21_09205)	-	1890096..1891313 (+)	1218	WP_000037075.1	YihY/virulence factor BrkB family protein	-
KMZ21_RS09210 (KMZ21_09210)	vraR	1891429..1892058 (-)	630	WP_000153530.1	two-component system response regulator VraR	Regulator
KMZ21_RS09215 (KMZ21_09215)	vraS	1892048..1893091 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
KMZ21_RS09220 (KMZ21_09220)	liaF	1893088..1893789 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
KMZ21_RS09225 (KMZ21_09225)	-	1893804..1894190 (-)	387	WP_001110179.1	hypothetical protein	-
KMZ21_RS09230 (KMZ21_09230)	map	1894407..1895165 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
KMZ21_RS09235 (KMZ21_09235)	-	1895693..1896679 (+)	987	WP_000999713.1	aromatic acid exporter family protein	-
KMZ21_RS09240 (KMZ21_09240)	-	1897109..1897522 (-)	414	WP_001549145.1	hypothetical protein	-
KMZ21_RS09245 (KMZ21_09245)	-	1897551..1897661 (-)	111	WP_001790257.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=571889 KMZ21_RS09215 WP_001017131.1 1892048..1893091(-) (vraS) [Staphylococcus aureus subsp. aureus RN4220]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=571889 KMZ21_RS09215 WP_001017131.1 1892048..1893091(-) (vraS) [Staphylococcus aureus subsp. aureus RN4220]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTTTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
TATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGATAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1