Detailed information NTG0057098

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: M1GAS476_RS06285
• Genome accession: NC_020540
• Coordinates: 1239408..1240445 (-)
• Length: 345 a.a.
• NCBI ID: WP_010922499.1
• Uniprot ID: A0A4U9I5V9
• Organism: Streptococcus pyogenes M1 476
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 1234408..1245445

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
M1GAS476_RS06265 (M1GAS476_1941)	-	1235159..1235785 (+)	627	WP_010922497.1	prepilin peptidase	-
M1GAS476_RS06270 (M1GAS476_1326)	rlmN	1235867..1236946 (-)	1080	WP_002992788.1	23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN	-
M1GAS476_RS06275 (M1GAS476_1327)	-	1236950..1237570 (-)	621	WP_011285637.1	YutD family protein	-
M1GAS476_RS06280 (M1GAS476_1328)	-	1238018..1238994 (-)	977	Protein_1214	LacI family DNA-binding transcriptional regulator	-
M1GAS476_RS06285 (M1GAS476_1330)	sepM	1239408..1240445 (-)	1038	WP_010922499.1	SepM family pheromone-processing serine protease	Regulator
M1GAS476_RS06290 (M1GAS476_1331)	coaD	1240432..1240923 (-)	492	WP_002983821.1	pantetheine-phosphate adenylyltransferase	-
M1GAS476_RS06295 (M1GAS476_1332)	rsmD	1240913..1241452 (-)	540	WP_002983819.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
M1GAS476_RS06300 (M1GAS476_1333)	asnA	1241575..1242567 (-)	993	WP_010922500.1	aspartate--ammonia ligase	-
M1GAS476_RS06305 (M1GAS476_1334)	arcC	1242880..1243830 (-)	951	WP_010922501.1	carbamate kinase	-
M1GAS476_RS06310 (M1GAS476_1335)	-	1243850..1245181 (-)	1332	WP_011285641.1	dipeptidase	-

Sequence

Protein

• Length: 345 a.a.
• Molecular weight: 37541.24 Da
• Isoelectric Point: 9.6692

>NTDB_id=57098 M1GAS476_RS06285 WP_010922499.1 1239408..1240445(-) (sepM) [Streptococcus pyogenes M1 476]
MKRLKKIKWWLVGLLALISLLLALFFPLPYYIEMPGGAYDIRTVLQVNGKEDKRKGAYQFVAVGISRASLAQLLYAWLTP
FTEISTAEDTTGGYSDADFLRINQFYMETSQNAAIYQALSLAGKPVTLDYKGVYVLDVNNESTFKGTLHLADTVTGVNGK
QFTSSAELIDYVSHLKLGDEVTVQFTSDNKPKKGVGRIIKLKNGKNGIGIALTDHTSVNSEDTVIFSTKGVGGPSAGLMF
TLDIYDQITKEDLRKGRTIAGTGTIGKDGEVGDIGGAGLKVVAAAEAGADIFFVPNNPVDKEIKKVNPNAISNYEEAKRA
AKRLKTKMKIVPVTTVQEALVYLRK

Nucleotide

• Length: 1038 bp

>NTDB_id=57098 M1GAS476_RS06285 WP_010922499.1 1239408..1240445(-) (sepM) [Streptococcus pyogenes M1 476]
ATGAAAAGACTTAAAAAAATCAAATGGTGGTTAGTGGGTCTGCTAGCTTTAATCTCTTTGTTGCTAGCGTTATTTTTTCC
GCTACCTTATTATATTGAAATGCCTGGAGGCGCTTACGATATTCGGACTGTCTTACAAGTCAATGGCAAAGAAGACAAAC
GAAAAGGAGCTTACCAGTTTGTTGCAGTGGGCATTAGTCGTGCCAGCCTCGCTCAGCTATTATATGCTTGGCTGACACCG
TTTACTGAAATTAGTACAGCAGAAGATACAACAGGCGGATACAGCGATGCTGATTTCCTTCGAATTAATCAATTTTACAT
GGAAACATCACAAAATGCAGCTATTTATCAAGCTTTATCCTTAGCTGGAAAACCAGTTACATTAGATTATAAAGGCGTAT
ATGTTTTAGACGTAAACAACGAATCTACTTTTAAAGGAACGCTACACTTAGCAGATACTGTAACAGGTGTAAATGGTAAA
CAGTTTACTAGTTCAGCAGAACTTATTGACTATGTTTCTCACCTAAAACTAGGGGATGAAGTTACGGTTCAGTTTACGAG
TGATAATAAGCCTAAAAAAGGAGTTGGCCGTATTATCAAACTGAAAAATGGGAAAAATGGGATTGGCATTGCCTTGACTG
ATCATACAAGTGTCAATTCAGAAGACACAGTGATCTTTAGTACTAAAGGAGTAGGAGGACCTAGTGCTGGTCTAATGTTT
ACTCTTGATATATATGATCAAATAACTAAAGAAGATTTACGCAAGGGCCGTACAATTGCAGGTACAGGAACTATTGGCAA
GGATGGCGAAGTAGGAGATATTGGTGGTGCAGGTCTTAAAGTAGTTGCAGCAGCTGAAGCTGGTGCAGATATATTTTTTG
TTCCGAATAATCCTGTTGATAAGGAAATTAAAAAAGTTAATCCAAATGCTATAAGTAATTACGAAGAAGCCAAACGGGCA
GCCAAACGACTAAAGACCAAAATGAAGATTGTTCCTGTTACGACTGTTCAAGAGGCACTGGTTTATCTTCGCAAATAA

Domains

Predicted by InterproScan.

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (233-309)

• PDZ domain (PDZ_2) (129-192)

3D structure

• AlphaFold DB: A0A4U9I5V9

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	69.275	100	0.693