Detailed information NTG0056973

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: SAI4T8_RS09535
• Genome accession: NC_020533
• Coordinates: 1925687..1926730 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus subsp. aureus ST228
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1920687..1931730

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SAI4T8_RS09505 (SAI4T8_1014240)	-	1921108..1922364 (-)	1257	WP_001795108.1	aminopeptidase	-
SAI4T8_RS09510	-	1922367..1922567 (-)	201	WP_078066076.1	DUF1128 family protein	-
SAI4T8_RS09515 (SAI4T8_1014250)	-	1922714..1923178 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
SAI4T8_RS09520	-	1923185..1923460 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
SAI4T8_RS09525 (SAI4T8_1014260)	-	1923738..1924955 (+)	1218	WP_000037075.1	YihY/virulence factor BrkB family protein	-
SAI4T8_RS09530 (SAI4T8_1014270)	vraR	1925068..1925697 (-)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
SAI4T8_RS09535 (SAI4T8_1014280)	vraS	1925687..1926730 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
SAI4T8_RS09540 (SAI4T8_1014290)	liaF	1926727..1927428 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
SAI4T8_RS09545	-	1927443..1927829 (-)	387	WP_001110179.1	hypothetical protein	-
SAI4T8_RS09550 (SAI4T8_1014300)	map	1928046..1928804 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
SAI4T8_RS09560 (SAI4T8_1014310)	-	1929335..1930321 (+)	987	WP_000999717.1	aromatic acid exporter family protein	-
SAI4T8_RS09565 (SAI4T8_1014320)	-	1930752..1931165 (-)	414	WP_001557448.1	hypothetical protein	-
SAI4T8_RS09570	-	1931194..1931304 (-)	111	WP_001790257.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=56973 SAI4T8_RS09535 WP_001017131.1 1925687..1926730(-) (vraS) [Staphylococcus aureus subsp. aureus ST228]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=56973 SAI4T8_RS09535 WP_001017131.1 1925687..1926730(-) (vraS) [Staphylococcus aureus subsp. aureus ST228]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTATTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCATACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCTCGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTTTCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGATAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1