NTDB

Overview

Name	ciaR	Type	Regulator
Locus tag	MKK05_RS22140	Genome accession	NZ_CP092634
Coordinates	4758635..4759306 (-)	Length	223 a.a.
NCBI ID	WP_003085524.1	Uniprot ID	A0A0H2Z6L5
Organism	Pseudomonas aeruginosa strain LS.2c
Function	repress competence development; post-transcriptional repression of CSP production (predicted from homology) Competence regulation

Genomic Context

Location: 4753635..4764306

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
MKK05_RS22115 (MKK05_22115)	-	4754408..4754860 (-)	453	WP_023092191.1	protein YgfX	-
MKK05_RS22120 (MKK05_22120)	-	4754844..4755098 (-)	255	WP_003085532.1	succinate dehydrogenase assembly factor 2	-
MKK05_RS22125 (MKK05_22125)	-	4755371..4756315 (+)	945	WP_033990008.1	folate-binding protein YgfZ	-
MKK05_RS22130 (MKK05_22130)	-	4756416..4757252 (+)	837	WP_003085528.1	HDOD domain-containing protein	-
MKK05_RS22135 (MKK05_22135)	-	4757260..4758642 (-)	1383	WP_003085526.1	sensor histidine kinase	-
MKK05_RS22140 (MKK05_22140)	ciaR	4758635..4759306 (-)	672	WP_003085524.1	response regulator	Regulator
MKK05_RS22145 (MKK05_22145)	-	4759517..4760800 (+)	1284	WP_003140943.1	OprD family porin	-
MKK05_RS22150 (MKK05_22150)	-	4760830..4761813 (+)	984	WP_003085519.1	tripartite tricarboxylate transporter substrate binding protein	-
MKK05_RS22155 (MKK05_22155)	-	4761862..4762332 (+)	471	WP_021264282.1	tripartite tricarboxylate transporter TctB family protein	-
MKK05_RS22160 (MKK05_22160)	-	4762343..4763860 (+)	1518	WP_003085514.1	tripartite tricarboxylate transporter permease	-

Sequence

Protein

Download Length: 223 a.a. Molecular weight: 24431.24 Da Isoelectric Point: 5.1881

                                >NTDB_id=567487 MKK05_RS22140 WP_003085524.1 4758635..4759306(-) (ciaR) [Pseudomonas aeruginosa strain LS.2c]

MRILLVEDHPQLAESVVQALKGAGWTVDLLQDGVAADLALASEEYALAILDVGLPRMDGFEVLARLRGRGKTLPVLMLTA

RGEVKDRVHGLNLGADDYLAKPFELSELEARVKALLRRSVLGGEQLQRCGALVYDLGTRRFSLDEQPLTLTSREQAVLEA

MIARPGRVMSKEQLAAQVFGLDEEASADAIEIYVHRLRKKLEGGAVRIVTFRGLGYLLEAQGD

Nucleotide

Download Length: 672 bp

                                >NTDB_id=567487 MKK05_RS22140 WP_003085524.1 4758635..4759306(-) (ciaR) [Pseudomonas aeruginosa strain LS.2c]

ATGCGCATCCTTCTGGTGGAAGATCATCCGCAGCTCGCCGAAAGCGTGGTCCAGGCGCTCAAGGGCGCTGGCTGGACGGT

AGACCTGCTGCAGGACGGGGTGGCCGCCGACCTGGCCCTGGCCAGCGAGGAGTACGCCCTGGCGATTCTCGACGTCGGCC

TGCCGCGGATGGACGGCTTCGAGGTGCTGGCGCGCCTGCGCGGGCGCGGCAAGACCTTGCCGGTGCTGATGCTGACTGCG

CGCGGCGAGGTGAAGGACCGGGTGCACGGCCTCAATCTCGGCGCCGACGACTACCTGGCAAAGCCTTTCGAACTGTCCGA

GCTGGAGGCGCGGGTCAAGGCCCTGCTGCGCCGCAGCGTGCTCGGCGGCGAACAGTTGCAGCGCTGCGGCGCCCTGGTCT

ACGACCTCGGCACTCGGCGCTTCAGCCTCGACGAGCAGCCGCTGACCCTGACCTCGCGGGAACAGGCGGTGCTGGAAGCG

ATGATCGCCCGTCCGGGGCGGGTGATGAGCAAGGAGCAACTGGCCGCCCAGGTCTTCGGCCTGGACGAGGAGGCCAGCGC

CGACGCCATCGAGATCTACGTCCACCGCCTGCGCAAGAAGCTGGAAGGCGGCGCCGTGCGCATCGTCACCTTCCGCGGCC

TCGGCTACCTGCTGGAGGCGCAGGGTGACTGA

Domains

Predicted by InterProScan.

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(146-218)

Response regulator receiver domain (Response_reg)

(3-112)

Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.

3D structure

Source	ID	Structure
AlphaFold DB	A0A0H2Z6L5

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.

Visualization of predicted probability:

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	H_a-value
ciaR	Streptococcus pneumoniae Rx1	37.668	100	0.377
ciaR	Streptococcus pneumoniae D39	37.668	100	0.377
ciaR	Streptococcus pneumoniae R6	37.668	100	0.377
ciaR	Streptococcus pneumoniae TIGR4	37.668	100	0.377
covR	Lactococcus lactis subsp. lactis strain DGCC12653	37.668	100	0.377

Detailed information NTG0567487