Detailed information    

insolico Bioinformatically predicted

Overview

Name   clpC   Type   Regulator
Locus tag   LILO_RS02850 Genome accession   NC_020450
Coordinates   557688..560138 (+) Length   816 a.a.
NCBI ID   WP_012897346.1    Uniprot ID   S6FJR3
Organism   Lactococcus lactis subsp. lactis IO-1     
Function   degradation of ComX (predicted from homology)   
Competence regulation

Genomic Context

Location: 552688..565138
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  LILO_RS02825 (lilo_0519) - 553452..553964 (+) 513 WP_012897343.1 adenine phosphoribosyltransferase -
  LILO_RS02830 (lilo_0520) rpoE 554181..554744 (+) 564 WP_012897344.1 DNA-directed RNA polymerase subunit delta -
  LILO_RS02835 (lilo_0521) mltG 554881..556533 (+) 1653 WP_042230133.1 endolytic transglycosylase MltG -
  LILO_RS02840 (lilo_0522) greA 556593..557066 (+) 474 WP_025016857.1 transcription elongation factor GreA -
  LILO_RS02845 (lilo_0523) - 557243..557698 (+) 456 WP_010905471.1 CtsR family transcriptional regulator -
  LILO_RS02850 (lilo_0524) clpC 557688..560138 (+) 2451 WP_012897346.1 ATP-dependent Clp protease ATP-binding subunit Regulator
  LILO_RS02855 (lilo_0525) hpf 560273..560830 (+) 558 WP_003129564.1 ribosome hibernation-promoting factor, HPF/YfiA family -
  LILO_RS02860 (lilo_0526) eno 561021..562322 (+) 1302 WP_010905473.1 surface-displayed alpha-enolase -
  LILO_RS02865 (lilo_0527) - 562437..563108 (-) 672 WP_015425956.1 ABC transporter ATP-binding protein -
  LILO_RS02870 (lilo_0528) - 563111..564184 (-) 1074 WP_015425957.1 ABC transporter permease -
  LILO_RS02875 (lilo_0529) - 564196..564765 (-) 570 WP_015425958.1 TetR/AcrR family transcriptional regulator -

Sequence

Protein


Download         Length: 816 a.a.        Molecular weight: 90425.82 Da        Isoelectric Point: 6.5300

>NTDB_id=56463 LILO_RS02850 WP_012897346.1 557688..560138(+) (clpC) [Lactococcus lactis subsp. lactis IO-1]
MKFENIKYTPTLDRILEKAEEYAHQYQYGTIESAHLLAAMATTSGSIAYSLLAGMNVDSSDLLIDLEDLSSHVKVKRSTL
RFSPRAEEVMTAASFLAIHNNSEAVGTEHLLYALLQVEDGFGLQLLKLQKINIVSLRKELEKRTGLKVPESKKAVTPMSK
RKMAKGVAENSTTPTLDSVSSDLTEEARLGKLDPMIGREAEIDRLIHILSRRTKNNPVLVGEPGVGKSAIIEGLAQRIVN
GQVPIGLMNSRIMALNMATVVAGTKFRGEFEDRLTAIVEEVSSDPDVIIFIDELHTIIGAGGGMDSVNDAANILKPALAR
GDFQMVGATTYHEYQKYIEKDEALERRLARINVDEPSPDEAIAILQGLREKFEDYHQVKFTDQAIKSAVMLSVRYMTSRK
LPDKAIDLLDEAAAAVKISVKNQQTKRLDLEKELAEAQEELSEAVIKLDIKASRTKEKAVEKIADKIYKFSVKEDKRQEV
TDQAVVAVASTLTGVPITQMTKSESDRLINLEKELHKRVVGQEEAISAVSRAIRRARSGVADSRRPMGSFMFLGPTGVGK
TELAKALADSVFGSEDNMIRVDMSEFMEKHSTSRLIGAPPGYVGYDEGGQLTERVRNKPYSVVLLDEVEKAHPDVFNIML
QILDDGFVTDTKGRKVDFRNTIIIMTSNLGATALRDDKTVGFGAKNITADYSAMKSRILEELKRHYRPEFLNRIDENIVF
HSLESQEIEQIVKIMSKSLIKRLAEQDIHVKLTPSAVKLIAEVGFDPEYGARPLRKALQKEVEDLLSEQLLSGEIKAGNH
VSIGASNKKIKIAQIV

Nucleotide


Download         Length: 2451 bp        

>NTDB_id=56463 LILO_RS02850 WP_012897346.1 557688..560138(+) (clpC) [Lactococcus lactis subsp. lactis IO-1]
ATGAAATTTGAAAATATAAAATATACACCAACGCTTGACCGAATTTTAGAAAAAGCGGAAGAGTATGCTCACCAATATCA
ATATGGCACCATTGAAAGTGCTCATTTACTGGCTGCAATGGCAACGACCTCAGGCTCAATTGCTTACAGCCTTCTTGCTG
GAATGAATGTTGATTCTTCTGACTTACTGATTGATTTAGAGGATTTATCAAGTCATGTTAAGGTCAAACGTTCAACTTTA
CGTTTTTCACCTCGTGCAGAAGAAGTGATGACTGCGGCAAGTTTTTTAGCAATTCATAATAACTCAGAAGCCGTTGGAAC
AGAACACCTGCTTTATGCCCTACTTCAAGTAGAAGATGGATTTGGTCTTCAACTTCTGAAATTACAAAAAATCAATATTG
TATCTTTGCGAAAAGAGCTTGAGAAAAGAACTGGACTCAAAGTTCCAGAAAGTAAAAAAGCTGTGACTCCAATGTCAAAA
CGTAAGATGGCAAAGGGAGTTGCAGAAAATTCAACGACGCCAACGTTAGACTCTGTATCCTCAGATTTAACCGAAGAAGC
TCGCTTGGGTAAACTTGACCCAATGATTGGACGAGAAGCTGAAATTGACCGTTTGATTCATATTCTCAGCCGCAGAACAA
AAAATAACCCTGTCTTAGTTGGAGAGCCCGGTGTTGGGAAATCAGCAATTATTGAAGGTTTGGCTCAAAGAATTGTCAAT
GGTCAAGTTCCAATTGGTTTGATGAATAGTCGAATTATGGCTTTGAATATGGCGACTGTTGTTGCTGGGACAAAATTTAG
AGGTGAATTTGAGGATCGCTTGACAGCTATTGTTGAAGAAGTTAGCAGTGATCCAGATGTCATTATTTTCATTGATGAAT
TACACACAATCATCGGTGCTGGTGGCGGAATGGATTCTGTCAATGATGCCGCAAATATTTTGAAACCAGCGCTTGCTCGT
GGTGATTTTCAAATGGTCGGAGCAACAACCTATCATGAATATCAAAAATATATTGAAAAAGATGAAGCTTTAGAACGGCG
TTTGGCGAGAATAAATGTTGACGAGCCAAGTCCAGATGAAGCGATTGCTATCTTGCAAGGCTTACGTGAAAAATTTGAAG
ACTATCATCAAGTGAAATTTACTGACCAAGCCATTAAAAGTGCCGTAATGCTCAGCGTTCGCTATATGACTAGCCGAAAA
TTGCCTGACAAAGCCATTGATTTACTTGATGAAGCTGCAGCAGCAGTGAAAATTTCTGTCAAAAATCAACAAACAAAACG
TCTTGATTTAGAAAAAGAACTAGCGGAAGCTCAAGAAGAATTATCAGAAGCTGTCATTAAACTTGATATCAAAGCGTCTC
GTACAAAAGAAAAAGCAGTTGAAAAAATTGCTGACAAGATTTATAAATTCTCAGTAAAAGAAGATAAACGTCAAGAAGTT
ACTGATCAAGCTGTTGTTGCTGTTGCCTCAACACTGACAGGCGTTCCAATCACACAAATGACTAAGTCTGAAAGTGATCG
TTTAATCAATCTTGAAAAAGAATTACACAAACGGGTTGTTGGACAAGAAGAAGCTATTTCTGCCGTTTCAAGAGCCATTC
GTCGGGCACGTTCTGGTGTTGCTGACAGCCGCCGTCCAATGGGTTCTTTCATGTTCCTTGGACCAACAGGGGTCGGTAAA
ACCGAACTTGCTAAAGCACTGGCTGACAGTGTGTTTGGTAGTGAAGATAATATGATTCGTGTTGACATGAGTGAATTCAT
GGAAAAACATTCAACTTCACGCTTGATTGGAGCTCCTCCAGGGTATGTAGGTTATGATGAGGGTGGTCAATTGACAGAAC
GCGTTCGTAATAAACCTTATTCTGTTGTTCTTTTAGATGAAGTCGAAAAAGCTCATCCTGACGTTTTCAACATCATGTTG
CAAATTCTAGATGATGGCTTTGTGACTGATACTAAAGGTCGCAAAGTTGATTTCAGAAATACAATTATTATCATGACTTC
AAACTTGGGAGCGACTGCTCTTCGTGACGATAAGACAGTTGGTTTTGGCGCTAAAAATATCACAGCTGATTATTCAGCCA
TGAAATCAAGAATATTAGAAGAGCTTAAACGTCATTATCGTCCTGAGTTTCTTAATCGAATTGATGAAAATATTGTTTTC
CATTCATTGGAAAGTCAAGAGATTGAACAAATTGTTAAAATTATGAGTAAATCTTTGATTAAACGTCTGGCAGAACAAGA
TATTCATGTTAAACTCACACCGTCAGCGGTGAAACTAATTGCTGAGGTAGGTTTTGACCCAGAATATGGTGCACGTCCGC
TTCGTAAGGCACTTCAAAAAGAAGTCGAAGACCTTTTAAGTGAACAATTGCTCTCTGGTGAAATCAAAGCAGGTAATCAT
GTTTCAATTGGTGCATCTAATAAAAAAATTAAAATCGCTCAAATTGTTTGA

Domains

Predicted by InterproScan.

C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small)

(723-802)

Clp amino terminal domain, pathogenicity island component (Clp_N)

(19-69)

Clp amino terminal domain, pathogenicity island component (Clp_N)

(96-144)

ATPase family associated with various cellular activities (AAA) (AAA)

(218-334)

AAA domain (Cdc48 subfamily) (AAA_2)

(545-716)

AAA lid domain (AAA_lid_9)

(357-453)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB S6FJR3

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  clpC Lactococcus lactis subsp. lactis strain DGCC12653

100

100

1
  clpC Streptococcus thermophilus LMD-9

50.542

100

0.515
  clpC Streptococcus thermophilus LMG 18311

50.421

100

0.513
  clpC Streptococcus pneumoniae Rx1

48.798

100

0.498
  clpC Streptococcus pneumoniae D39

48.798

100

0.498
  clpC Bacillus subtilis subsp. subtilis str. 168

50.499

98.284

0.496
  clpC Streptococcus pneumoniae TIGR4

48.678

100

0.496
  clpC Streptococcus mutans UA159

48.558

100

0.495
  clpE Streptococcus mutans UA159

47.846

79.657

0.381
  clpC Lactococcus lactis subsp. cremoris KW2

47.023

80.27

0.377
  clpE Streptococcus pneumoniae TIGR4

47.687

76.838

0.366
  clpE Streptococcus pneumoniae Rx1

47.687

76.838

0.366
  clpE Streptococcus pneumoniae D39

47.687

76.838

0.366
  clpE Streptococcus pneumoniae R6

47.687

76.838

0.366

Multiple sequence alignment