Detailed information NTG0564580

Bioinformatically predicted

Overview

• Name: clpC
• Type: Regulator
• Locus tag: MCS24_RS00060
• Genome accession: NZ_CP092050
• Coordinates: 8915..11494 (+)
• Length: 859 a.a.
• NCBI ID: WP_005873897.1
• Uniprot ID: Q7MXY4
• Organism: Porphyromonas gingivalis strain W50/BR1
• Function: degradation of ComK; degradation of DegU (predicted from homology) Competence regulation

Genomic Context

Location: 3915..16494

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
MCS24_RS00030 (MCS24_00030)	-	5094..6473 (-)	1380	WP_005874765.1	MATE family efflux transporter	-
MCS24_RS00045 (MCS24_00045)	-	6933..7025 (-)	93	WP_230456082.1	DUF1661 domain-containing protein	-
MCS24_RS00050 (MCS24_00050)	-	6994..7092 (+)	99	WP_230456081.1	DUF1661 domain-containing protein	-
MCS24_RS00060 (MCS24_00060)	clpC	8915..11494 (+)	2580	WP_005873897.1	ATP-dependent Clp protease ATP-binding subunit	Regulator
MCS24_RS00065 (MCS24_00065)	-	11634..14645 (+)	3012	WP_005873896.1	glycoside hydrolase family 3 N-terminal domain-containing protein	-
MCS24_RS00070 (MCS24_00070)	-	14693..15721 (+)	1029	WP_004583413.1	histidinol-phosphate transaminase	-

Sequence

Protein

• Length: 859 a.a.
• Molecular weight: 95426.89 Da
• Isoelectric Point: 4.7314

>NTDB_id=564580 MCS24_RS00060 WP_005873897.1 8915..11494(+) (clpC) [Porphyromonas gingivalis strain W50/BR1]
MAYDFTQTFRNSLEYSYQEATRLGVVAVTQDMLVLGIIRDGDNGAIDIMRHYGINLYELKRLIELEAIAESLPASPEGSP
IFTPSAREAIDDATDICADMEDEAVSPVHLLLSILNSTQESLVQKIFMKQGIKYDTILSDYFGQRNPSEGKSPSEMEILD
GYQDNDFDDEEDESSPPSGNSGTGGGSGDAPEQNTGGGDTTTTTRSGGDTPALDTFGTDITAMAAAGKLDPVVGREQEIE
RVIQILSRRKKNNPVLIGEPGVGKSAIVEGLAERIVNRKVSRILFDKRIISLDLAQMVAGTKYRGQFEERLKAVLDELKK
NPQIILFIDEIHTIVGAGSAAGSMDTANMLKPALARGQVQCIGATTLDEYRKNIEKDGALERRFQKVPIAPSTAEETLTI
LQNIKEKYEDYHGVRYTDEAIKAAVELTDRYVSDRFFPDKAIDAMDEAGASVHITNVVAPKEIEILEAELASVRENKLSA
VKAQNYELAASFRDQERRTQQQIAEEKKKWEEQMSKHRETVDENVVAHVVALMTGVPAERLSTGEGERLRTMADDLKTKV
VGQDTAIEKMVHAIQRNRLGLRNEKKPIGSFLFLGPTGVGKTYLAKKLAEYLFEDENAMIRVDMSEYMEKFSVSRLVGAP
PGYVGYEEGGQLTERVRRKPYSVVLLDEIEKAHADVFNLLLQVMDEGQLTDSLGRRVNFKNTVIIITSNVGTRQLKDFGQ
GIGFRSEKDEEANKEHSRSVIQKALNKTFSPEFLNRLDDIILFDQLGKTEIRRMVDIELKAVLARIHRAGYDLVLTDEAK
DVIATKGYDLQYGARPLKRTLQNEVEDRLTDLILSGQIEKGQTLTLSARDGEIIVQEQA

Nucleotide

• Length: 2580 bp

>NTDB_id=564580 MCS24_RS00060 WP_005873897.1 8915..11494(+) (clpC) [Porphyromonas gingivalis strain W50/BR1]
ATGGCATACGACTTTACACAAACATTCCGCAACAGCCTGGAGTACAGCTATCAGGAAGCAACCCGTCTCGGCGTCGTAGC
CGTGACGCAAGATATGCTCGTACTCGGTATCATTCGCGACGGAGACAATGGCGCGATCGACATCATGCGGCACTATGGGA
TCAACTTGTACGAACTCAAACGGTTGATCGAGTTGGAAGCCATCGCCGAGAGTTTGCCTGCTTCGCCTGAGGGATCGCCC
ATCTTCACCCCTTCGGCTCGGGAGGCTATCGATGATGCCACAGACATCTGTGCCGACATGGAGGACGAGGCCGTCAGCCC
GGTCCATCTGTTGCTGAGTATCCTCAACTCGACACAGGAGAGCTTAGTACAAAAGATATTTATGAAACAAGGTATAAAAT
ACGACACCATCCTGTCGGATTACTTCGGACAGCGCAACCCCTCCGAAGGGAAGTCTCCCTCCGAAATGGAGATCCTCGAC
GGGTACCAAGACAACGACTTCGACGACGAAGAGGACGAATCCTCTCCGCCTTCCGGGAATAGCGGGACAGGCGGAGGCTC
CGGCGACGCCCCCGAACAGAATACCGGCGGAGGCGATACTACCACCACGACACGGAGTGGAGGCGACACGCCTGCACTGG
ACACCTTCGGCACCGACATCACTGCCATGGCGGCAGCAGGCAAGCTCGACCCGGTAGTGGGTCGGGAGCAGGAGATCGAA
AGGGTGATACAGATACTCAGCCGGCGCAAAAAGAACAATCCGGTGCTCATCGGCGAACCCGGTGTAGGCAAGAGTGCCAT
CGTGGAAGGACTGGCCGAACGCATCGTGAACAGGAAGGTGAGCCGTATTCTTTTCGACAAGCGGATCATCAGCCTCGATT
TGGCTCAGATGGTAGCCGGCACCAAATATCGCGGACAGTTCGAAGAGCGGTTGAAAGCCGTGCTCGATGAGCTGAAGAAG
AATCCGCAGATCATCCTCTTCATCGACGAGATACATACCATCGTGGGAGCAGGCTCTGCAGCCGGATCGATGGATACGGC
CAATATGCTCAAACCCGCTCTTGCCCGTGGACAGGTACAGTGCATCGGAGCCACTACGCTGGATGAGTATCGTAAGAACA
TAGAAAAGGACGGAGCACTCGAACGCCGCTTCCAGAAGGTGCCGATAGCCCCCTCGACTGCAGAAGAAACGCTGACCATC
CTGCAAAACATCAAAGAGAAATACGAGGACTATCACGGTGTACGCTATACGGACGAAGCGATCAAAGCGGCAGTGGAACT
GACCGATCGCTATGTATCCGATCGTTTCTTCCCAGATAAGGCGATAGATGCCATGGACGAGGCCGGCGCGAGCGTCCATA
TCACCAATGTGGTGGCTCCGAAAGAAATCGAGATACTGGAGGCCGAATTGGCATCGGTGCGAGAGAACAAGCTCTCGGCC
GTAAAGGCTCAGAACTACGAACTGGCTGCCTCCTTCCGCGATCAGGAGCGGCGCACTCAGCAGCAGATAGCGGAAGAGAA
GAAAAAATGGGAAGAGCAGATGTCCAAGCACCGCGAGACGGTGGACGAGAATGTAGTGGCGCATGTAGTGGCGTTGATGA
CAGGCGTTCCGGCTGAGCGGCTGAGCACGGGCGAAGGCGAACGTCTGCGCACGATGGCAGATGATCTCAAGACCAAAGTA
GTAGGTCAGGACACAGCCATCGAAAAGATGGTGCATGCCATCCAGCGCAATCGTCTGGGACTTCGCAATGAAAAGAAACC
GATCGGTTCTTTCCTTTTCCTCGGCCCCACGGGGGTAGGCAAGACCTATTTGGCCAAGAAGCTCGCCGAATACCTGTTCG
AGGATGAGAATGCCATGATCAGGGTGGATATGAGCGAGTATATGGAGAAGTTCTCCGTTTCGCGTCTCGTGGGTGCCCCT
CCGGGATATGTGGGCTATGAAGAAGGCGGCCAACTGACGGAGCGCGTAAGACGCAAACCCTATTCCGTGGTTCTCTTGGA
TGAGATCGAAAAGGCGCATGCCGATGTCTTCAATCTGCTCTTACAGGTGATGGACGAAGGTCAGCTGACCGACAGTCTGG
GACGGCGCGTGAATTTCAAGAACACCGTGATCATCATCACCTCCAACGTGGGTACACGCCAGCTCAAAGACTTCGGGCAG
GGTATCGGGTTCCGTTCGGAAAAAGACGAGGAAGCGAACAAGGAGCATAGCCGTTCCGTGATCCAAAAAGCTCTGAACAA
GACGTTCAGCCCCGAATTTCTCAACCGTTTGGACGATATCATCCTCTTCGACCAACTGGGCAAGACGGAGATTCGCCGGA
TGGTGGACATAGAGCTTAAAGCCGTCTTGGCGCGCATCCATCGTGCCGGATACGACCTCGTCCTTACCGATGAAGCCAAG
GATGTGATAGCGACGAAGGGATACGACCTCCAATACGGAGCACGACCGCTCAAGCGCACACTCCAGAACGAAGTGGAGGA
TCGCCTCACGGATCTTATCCTCTCCGGACAGATCGAGAAAGGGCAGACGCTTACGCTCTCTGCTCGCGATGGCGAGATCA
TCGTACAAGAACAAGCATAA

Domains

Predicted by InterProScan.

• AAA domain (Cdc48 subfamily) (AAA_2) (586-760)

• Clp amino terminal domain, pathogenicity island component (Clp_N) (19-64)

• Clp amino terminal domain, pathogenicity island component (Clp_N) (95-138)

• ATPase family associated with various cellular activities (AAA) (AAA) (255-383)

• C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small) (766-845)

• AAA lid domain (AAA_lid_9) (394-494)

3D structure

• AlphaFold DB: Q7MXY4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
clpC	Bacillus subtilis subsp. subtilis str. 168	44.743	99.651	0.446
clpC	Lactococcus lactis subsp. cremoris KW2	46.06	85.681	0.395
clpE	Streptococcus mutans UA159	50.539	75.553	0.382
clpC	Lactococcus lactis subsp. lactis strain DGCC12653	50.543	75.087	0.38
clpE	Streptococcus pneumoniae R6	49.922	74.389	0.371
clpE	Streptococcus pneumoniae TIGR4	49.922	74.389	0.371
clpE	Streptococcus pneumoniae Rx1	49.922	74.389	0.371
clpE	Streptococcus pneumoniae D39	49.922	74.389	0.371