Detailed information NTG0562145

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: KFV55_RS04965
• Genome accession: NZ_CP073904
• Coordinates: 946518..947564 (+)
• Length: 348 a.a.
• NCBI ID: WP_001830374.1
• Uniprot ID: A0A0N1EGU4
• Organism: Staphylococcus epidermidis strain V1950266
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 941518..952564

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
KFV55_RS04940 (KFV55_04940)	-	942659..943195 (+)	537	WP_002470337.1	hypothetical protein	-
KFV55_RS04945 (KFV55_04945)	-	943346..944332 (-)	987	WP_001830388.1	aromatic acid exporter family protein	-
KFV55_RS04950 (KFV55_04950)	map	944506..945261 (+)	756	WP_002457092.1	type I methionyl aminopeptidase	-
KFV55_RS04955 (KFV55_04955)	-	945419..945805 (+)	387	WP_001830382.1	hypothetical protein	-
KFV55_RS04960 (KFV55_04960)	liaF	945820..946521 (+)	702	WP_001830436.1	cell wall-active antibiotics response protein LiaF	-
KFV55_RS04965 (KFV55_04965)	vraS	946518..947564 (+)	1047	WP_001830374.1	sensor histidine kinase	Regulator
KFV55_RS04970 (KFV55_04970)	vraR	947554..948183 (+)	630	WP_001830439.1	two-component system response regulator VraR	Regulator
KFV55_RS04975 (KFV55_04975)	-	948240..949418 (-)	1179	WP_001830411.1	YihY/virulence factor BrkB family protein	-
KFV55_RS04980 (KFV55_04980)	-	949825..950109 (-)	285	WP_001830401.1	YtxH domain-containing protein	-
KFV55_RS04985 (KFV55_04985)	-	950117..950581 (-)	465	WP_001830437.1	low molecular weight protein-tyrosine-phosphatase	-
KFV55_RS04990 (KFV55_04990)	-	950722..950937 (+)	216	WP_001830421.1	DUF1128 domain-containing protein	-
KFV55_RS04995 (KFV55_04995)	-	950939..952180 (+)	1242	WP_001832467.1	aminopeptidase	-

Sequence

Protein

• Length: 348 a.a.
• Molecular weight: 40066.49 Da
• Isoelectric Point: 5.8512

>NTDB_id=562145 KFV55_RS04965 WP_001830374.1 946518..947564(+) (vraS) [Staphylococcus epidermidis strain V1950266]
MNHYIRAIGSMLILVYSMLIAFLFIDKVFVNIIFFQGMFYTQIFGIPVFLFLNLLIVLLCIIVGSVLAYKINQQNDWIIS
QIERSIEGQTVGINDQNIELYTETIDIYHTLVPLNQELHRLRMKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKESKLEPPLNQQIPILEKMVQDSQLEMRALLLHLRPIGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFEVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNQEDYLLLRIQDNGKGFNVDEKFEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEENSSGD

Nucleotide

• Length: 1047 bp

>NTDB_id=562145 KFV55_RS04965 WP_001830374.1 946518..947564(+) (vraS) [Staphylococcus epidermidis strain V1950266]
ATGAATCACTACATAAGAGCTATAGGCTCAATGCTTATATTAGTATATAGTATGCTTATTGCTTTTTTATTTATTGATAA
AGTGTTTGTAAATATTATCTTTTTTCAGGGGATGTTTTATACACAAATATTTGGAATACCTGTTTTTCTATTTTTAAATT
TATTAATTGTTCTTTTATGTATTATAGTTGGATCTGTTTTAGCTTATAAAATTAATCAACAAAATGATTGGATTATTTCA
CAAATAGAAAGATCAATAGAAGGACAAACAGTAGGTATCAATGATCAAAATATCGAATTATATACAGAAACGATAGATAT
TTATCATACACTAGTTCCATTAAATCAAGAATTACATCGACTTAGAATGAAGACTCAAAATTTAACTAATGAAAACTACA
ATATTAATGATGTAAAAGTCAAAAAGATTATCGAAGATGAGCGACAACGACTTGCCAGGGAATTACATGATTCTGTTAGT
CAACAATTATTTGCTGCGAGCATGATGCTATCGGCGATAAAAGAGTCGAAATTAGAACCACCTTTAAATCAACAGATACC
AATTCTTGAAAAAATGGTTCAAGACTCACAACTTGAAATGAGAGCTTTGTTATTACATTTAAGACCGATAGGTTTAAAAG
ATAAGTCTTTAGGTGAAGGAATTAAAGATTTAGTCATCGATTTACAAAAGAAAGTACCAATGAAAGTTGTGCATGAAATT
CAAGATTTTGAAGTGCCAAAAGGCATTGAAGATCACTTGTTCAGAATTACACAAGAAGCTATTTCAAATACATTGAGACA
TTCAAATGGTACAAAAGTAACTGTGGAATTATTTAATCAAGAGGATTATCTTTTACTAAGAATTCAAGATAATGGAAAAG
GGTTTAATGTAGATGAAAAATTTGAACAAAGTTATGGTTTGAAAAATATGCGAGAACGAGCGTTAGAAATTGGTGCGACG
TTTCATATTGTATCTTTACCTGATTCAGGTACACGAATTGAAGTTAAGGCACCATTGAATAAGGAGGAGAATTCAAGTGG
CGATTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0N1EGU4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	93.023	98.851	0.92