Detailed information
Bioinformatically predicted
Overview
| Name | ccrA | Type | Machinery gene |
| Locus tag | KFV25_RS12650 | Genome accession | NZ_CP073900 |
| Coordinates | 2602488..2603834 (+) | Length | 448 a.a. |
| NCBI ID | WP_000816499.1 | Uniprot ID | Q9R3W9 |
| Organism | Staphylococcus epidermidis strain V1949610 | ||
| Function | promote SCCmec transfer (predicted from homology) Homologous recombination |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| SCCmec | 2602488..2651149 | 2602488..2603834 | within | 0 |
Gene organization within MGE regions
Location: 2602488..2651149
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KFV25_RS12650 (KFV25_12660) | ccrA | 2602488..2603834 (+) | 1347 | WP_000816499.1 | recombinase family protein | Machinery gene |
| KFV25_RS12655 (KFV25_12665) | ccrB | 2603855..2605483 (+) | 1629 | WP_001186596.1 | recombinase family protein | Machinery gene |
| KFV25_RS12660 (KFV25_12670) | - | 2605954..2606304 (+) | 351 | WP_000171449.1 | SAUGI family uracil-DNA glycosylase inhibitor | - |
| KFV25_RS12665 (KFV25_12675) | - | 2606389..2606700 (+) | 312 | WP_000833212.1 | DUF960 family protein | - |
| KFV25_RS12670 (KFV25_12680) | - | 2606719..2607240 (+) | 522 | WP_000836008.1 | DUF1643 domain-containing protein | - |
| KFV25_RS12675 (KFV25_12685) | - | 2607242..2607448 (+) | 207 | WP_001077283.1 | hypothetical protein | - |
| KFV25_RS12680 (KFV25_12690) | - | 2607441..2607764 (+) | 324 | WP_000088091.1 | JAB domain-containing protein | - |
| KFV25_RS12685 (KFV25_12695) | - | 2607959..2609851 (+) | 1893 | WP_002485298.1 | site-specific integrase | - |
| KFV25_RS12690 (KFV25_12700) | - | 2609858..2610235 (+) | 378 | WP_001041908.1 | DUF6262 family protein | - |
| KFV25_RS12695 (KFV25_12705) | - | 2610473..2610838 (+) | 366 | WP_000159127.1 | metalloregulator ArsR/SmtB family transcription factor | - |
| KFV25_RS12700 (KFV25_12710) | - | 2610831..2613245 (+) | 2415 | WP_000378485.1 | cadmium-translocating P-type ATPase CadA | - |
| KFV25_RS12705 (KFV25_12715) | - | 2613326..2613942 (+) | 617 | Protein_2484 | CadD family cadmium resistance transporter | - |
| KFV25_RS12715 (KFV25_12725) | - | 2614216..2614854 (-) | 639 | Protein_2485 | sulfite exporter TauE/SafE family protein | - |
| KFV25_RS12720 (KFV25_12730) | cstR | 2614854..2615114 (-) | 261 | WP_000220507.1 | persulfide-sensing transcriptional repressor CstR | - |
| KFV25_RS12725 (KFV25_12735) | - | 2615250..2616314 (+) | 1065 | WP_000438836.1 | DsrE/DsrF/DrsH-like family protein | - |
| KFV25_RS12730 (KFV25_12740) | cstB | 2616347..2617681 (+) | 1335 | Protein_2488 | persulfide dioxygenase-sulfurtransferase CstB | - |
| KFV25_RS12735 (KFV25_12745) | - | 2617795..2618904 (-) | 1110 | WP_000943131.1 | ROK family transcriptional regulator | - |
| KFV25_RS12740 (KFV25_12750) | psm-mec | 2619259..2619327 (+) | 69 | WP_014532405.1 | phenol-soluble modulin PSM-mec | - |
| KFV25_RS12745 (KFV25_12755) | mecI | 2619412..2619783 (-) | 372 | WP_000369214.1 | mecA-type methicillin resistance repressor MecI | - |
| KFV25_RS12750 (KFV25_12760) | mecR1 | 2619783..2621540 (-) | 1758 | WP_000952923.1 | beta-lactam sensor/signal transducer MecR1 | - |
| KFV25_RS12755 (KFV25_12765) | mecA | 2621637..2623646 (+) | 2010 | WP_001801873.1 | PBP2a family beta-lactam-resistant peptidoglycan transpeptidase MecA | - |
| KFV25_RS12760 (KFV25_12770) | - | 2623692..2624120 (-) | 429 | WP_000872606.1 | MaoC family dehydratase | - |
| KFV25_RS12765 (KFV25_12775) | - | 2624217..2624960 (-) | 744 | WP_000958858.1 | glycerophosphoryl diester phosphodiesterase | - |
| KFV25_RS12770 (KFV25_12780) | - | 2625757..2626146 (-) | 390 | WP_020444595.1 | hydroxymethylglutaryl-CoA synthase | - |
| KFV25_RS12775 (KFV25_12785) | - | 2626182..2626856 (+) | 675 | WP_001106057.1 | IS6-like element IS257 family transposase | - |
| KFV25_RS12780 (KFV25_12790) | - | 2627301..2628557 (-) | 1257 | WP_000566670.1 | DUF3578 domain-containing protein | - |
| KFV25_RS12785 (KFV25_12795) | - | 2629000..2629545 (-) | 546 | WP_031869236.1 | YdhK family protein | - |
| KFV25_RS12790 (KFV25_12800) | - | 2629563..2629772 (-) | 210 | Protein_2500 | heavy metal translocating P-type ATPase | - |
| KFV25_RS12795 (KFV25_12805) | - | 2629942..2630700 (-) | 759 | WP_000623679.1 | sulfite exporter TauE/SafE family protein | - |
| KFV25_RS12800 (KFV25_12810) | - | 2630697..2630852 (-) | 156 | Protein_2502 | metal-sensing transcriptional repressor | - |
| KFV25_RS12810 (KFV25_12820) | - | 2631075..2631365 (-) | 291 | WP_012086558.1 | hypothetical protein | - |
| KFV25_RS12815 (KFV25_12825) | - | 2631417..2632289 (-) | 873 | WP_012086560.1 | HTH domain-containing protein | - |
| KFV25_RS12820 (KFV25_12830) | - | 2632459..2632905 (-) | 447 | WP_012086562.1 | JAB domain-containing protein | - |
| KFV25_RS12825 (KFV25_12835) | - | 2632933..2633439 (-) | 507 | WP_012086564.1 | DUF1643 domain-containing protein | - |
| KFV25_RS12830 (KFV25_12840) | - | 2633455..2633766 (-) | 312 | WP_001083109.1 | DUF960 family protein | - |
| KFV25_RS12835 (KFV25_12845) | - | 2633862..2634200 (-) | 339 | WP_012086569.1 | SAUGI family uracil-DNA glycosylase inhibitor | - |
| KFV25_RS12840 (KFV25_12850) | - | 2634306..2635982 (-) | 1677 | WP_012086571.1 | recombinase family protein | - |
| KFV25_RS12845 (KFV25_12855) | - | 2636209..2637852 (-) | 1644 | WP_012086574.1 | DUF5906 domain-containing protein | - |
| KFV25_RS12850 (KFV25_12860) | - | 2637849..2638220 (-) | 372 | WP_001058157.1 | hypothetical protein | - |
| KFV25_RS12855 (KFV25_12865) | - | 2638213..2639313 (-) | 1101 | WP_000449985.1 | DNA polymerase | - |
| KFV25_RS12860 (KFV25_12870) | - | 2639540..2641015 (-) | 1476 | WP_001138664.1 | DUF6038 family protein | - |
| KFV25_RS12865 (KFV25_12875) | - | 2641123..2641986 (-) | 864 | WP_000680579.1 | hypothetical protein | - |
| KFV25_RS12870 (KFV25_12880) | - | 2642184..2642489 (-) | 306 | WP_000677987.1 | hypothetical protein | - |
| KFV25_RS12875 (KFV25_12885) | - | 2643741..2645666 (-) | 1926 | WP_002485723.1 | heavy metal translocating P-type ATPase | - |
| KFV25_RS12880 (KFV25_12890) | - | 2645996..2646322 (-) | 327 | WP_000391495.1 | metalloregulator ArsR/SmtB family transcription factor | - |
| KFV25_RS12885 (KFV25_12895) | - | 2646529..2646888 (+) | 360 | WP_001631039.1 | hypothetical protein | - |
| KFV25_RS12890 (KFV25_12900) | - | 2647000..2647338 (-) | 339 | Protein_2519 | recombinase family protein | - |
| KFV25_RS12895 (KFV25_12905) | - | 2647347..2647976 (+) | 630 | Protein_2520 | hypothetical protein | - |
| KFV25_RS12900 (KFV25_12910) | ccrA | 2648163..2649524 (+) | 1362 | WP_001631036.1 | recombinase family protein | Machinery gene |
| KFV25_RS12905 (KFV25_12915) | ccrB | 2649521..2651149 (+) | 1629 | WP_001631035.1 | recombinase family protein | Machinery gene |
Sequence
Protein
Download Length: 448 a.a. Molecular weight: 52138.19 Da Isoelectric Point: 10.1760
>NTDB_id=562130 KFV25_RS12650 WP_000816499.1 2602488..2603834(+) (ccrA) [Staphylococcus epidermidis strain V1949610]
MKRAIGYLRQSTTKQQSLPAQKQAIELLAPKHNIQNIQYISDKQSGRTDNRTGYQQVTERIQQRQCDVLCCYRLNRLHRN
LKNALKLMKLCQKYHVHILSVHDGYFDMDKAFDRLKLNIFMSLAELESDNIGEQVKNGLREKAKQGKLITTHAPFGYHYQ
NGTFIINNDESPTVKAVFNYYLQGYGYKKIAQYLEDDNKLITRKPYQVRNIIMNPNYCGRVINQYGQYNNMVPPIVSATK
YEHAQAIRNKKQLHCIPSENQLKQKIKCPCCDSTLTNMTIRKKHTLRYYICPKNMNESRFVCSFKGINAQKLEVQVLATC
QNFFQNQQLYSKINNAIHQRLKKQRVIEAKSTLTQEQLIDKLAKGMIDAESFRKQTHLMNQKHKTISSISDNQLQTSLQK
VIQKSFTLNMLHPYIDEIRITKNKALVGIYFKNEPLNIVNQTSQSSIA
MKRAIGYLRQSTTKQQSLPAQKQAIELLAPKHNIQNIQYISDKQSGRTDNRTGYQQVTERIQQRQCDVLCCYRLNRLHRN
LKNALKLMKLCQKYHVHILSVHDGYFDMDKAFDRLKLNIFMSLAELESDNIGEQVKNGLREKAKQGKLITTHAPFGYHYQ
NGTFIINNDESPTVKAVFNYYLQGYGYKKIAQYLEDDNKLITRKPYQVRNIIMNPNYCGRVINQYGQYNNMVPPIVSATK
YEHAQAIRNKKQLHCIPSENQLKQKIKCPCCDSTLTNMTIRKKHTLRYYICPKNMNESRFVCSFKGINAQKLEVQVLATC
QNFFQNQQLYSKINNAIHQRLKKQRVIEAKSTLTQEQLIDKLAKGMIDAESFRKQTHLMNQKHKTISSISDNQLQTSLQK
VIQKSFTLNMLHPYIDEIRITKNKALVGIYFKNEPLNIVNQTSQSSIA
Nucleotide
Download Length: 1347 bp
>NTDB_id=562130 KFV25_RS12650 WP_000816499.1 2602488..2603834(+) (ccrA) [Staphylococcus epidermidis strain V1949610]
ATGAAACGAGCCATTGGTTATTTGCGCCAAAGTACAACGAAACAACAATCACTCCCAGCTCAAAAGCAAGCAATAGAATT
ATTAGCTCCAAAGCACAATATTCAAAATATCCAATACATTAGTGATAAGCAATCAGGCAGAACAGATAATCGAACAGGCT
ATCAACAAGTCACCGAACGCATCCAACAAAGACAATGTGACGTATTATGTTGTTATCGCTTGAATCGACTTCATCGCAAC
TTGAAAAATGCATTAAAACTCATGAAACTCTGTCAAAAATATCATGTTCATATTCTAAGTGTTCATGATGGCTATTTTGA
TATGGATAAAGCGTTTGATCGCCTAAAACTCAATATATTCATGAGTCTGGCTGAACTTGAATCCGATAATATTGGAGAAC
AAGTCAAAAATGGACTTAGAGAAAAGGCAAAACAAGGTAAACTCATAACGACCCATGCGCCTTTCGGTTATCACTATCAA
AATGGTACTTTCATCATTAATAATGATGAATCACCTACCGTCAAAGCTGTATTCAATTATTATCTTCAAGGATATGGCTA
CAAGAAGATTGCACAATATTTAGAAGACGATAATAAACTTATTACCCGCAAGCCTTATCAGGTACGAAATATAATTATGA
ACCCAAATTATTGTGGTCGTGTCATCAATCAATATGGTCAATATAACAATATGGTACCACCTATTGTTTCGGCAACGAAA
TATGAACATGCTCAAGCAATCCGTAATAAGAAGCAACTTCACTGTATACCTTCAGAGAATCAGCTGAAACAAAAGATCAA
ATGTCCTTGTTGTGACTCAACACTGACAAATATGACAATAAGAAAAAAACATACATTGCGATATTATATTTGTCCTAAAA
ATATGAATGAATCTCGCTTTGTCTGTTCATTCAAAGGAATAAATGCACAAAAATTAGAAGTTCAAGTCTTAGCTACATGT
CAGAACTTCTTTCAAAACCAACAGCTCTATTCAAAAATTAATAATGCAATTCATCAACGCCTCAAAAAACAAAGAGTGAT
AGAAGCTAAAAGTACGCTAACTCAAGAACAACTGATAGATAAACTTGCCAAAGGTATGATTGATGCTGAATCATTCAGAA
AACAGACTCATTTGATGAATCAAAAGCACAAAACCATATCCTCCATAAGTGATAATCAGTTACAAACATCACTACAAAAG
GTTATACAGAAAAGTTTCACGTTAAACATGCTGCATCCCTATATTGATGAAATTCGCATTACAAAAAATAAAGCCCTTGT
TGGGATCTATTTCAAAAATGAACCATTGAACATTGTGAACCAAACCTCGCAATCATCGATTGCTTAA
ATGAAACGAGCCATTGGTTATTTGCGCCAAAGTACAACGAAACAACAATCACTCCCAGCTCAAAAGCAAGCAATAGAATT
ATTAGCTCCAAAGCACAATATTCAAAATATCCAATACATTAGTGATAAGCAATCAGGCAGAACAGATAATCGAACAGGCT
ATCAACAAGTCACCGAACGCATCCAACAAAGACAATGTGACGTATTATGTTGTTATCGCTTGAATCGACTTCATCGCAAC
TTGAAAAATGCATTAAAACTCATGAAACTCTGTCAAAAATATCATGTTCATATTCTAAGTGTTCATGATGGCTATTTTGA
TATGGATAAAGCGTTTGATCGCCTAAAACTCAATATATTCATGAGTCTGGCTGAACTTGAATCCGATAATATTGGAGAAC
AAGTCAAAAATGGACTTAGAGAAAAGGCAAAACAAGGTAAACTCATAACGACCCATGCGCCTTTCGGTTATCACTATCAA
AATGGTACTTTCATCATTAATAATGATGAATCACCTACCGTCAAAGCTGTATTCAATTATTATCTTCAAGGATATGGCTA
CAAGAAGATTGCACAATATTTAGAAGACGATAATAAACTTATTACCCGCAAGCCTTATCAGGTACGAAATATAATTATGA
ACCCAAATTATTGTGGTCGTGTCATCAATCAATATGGTCAATATAACAATATGGTACCACCTATTGTTTCGGCAACGAAA
TATGAACATGCTCAAGCAATCCGTAATAAGAAGCAACTTCACTGTATACCTTCAGAGAATCAGCTGAAACAAAAGATCAA
ATGTCCTTGTTGTGACTCAACACTGACAAATATGACAATAAGAAAAAAACATACATTGCGATATTATATTTGTCCTAAAA
ATATGAATGAATCTCGCTTTGTCTGTTCATTCAAAGGAATAAATGCACAAAAATTAGAAGTTCAAGTCTTAGCTACATGT
CAGAACTTCTTTCAAAACCAACAGCTCTATTCAAAAATTAATAATGCAATTCATCAACGCCTCAAAAAACAAAGAGTGAT
AGAAGCTAAAAGTACGCTAACTCAAGAACAACTGATAGATAAACTTGCCAAAGGTATGATTGATGCTGAATCATTCAGAA
AACAGACTCATTTGATGAATCAAAAGCACAAAACCATATCCTCCATAAGTGATAATCAGTTACAAACATCACTACAAAAG
GTTATACAGAAAAGTTTCACGTTAAACATGCTGCATCCCTATATTGATGAAATTCGCATTACAAAAAATAAAGCCCTTGT
TGGGATCTATTTCAAAAATGAACCATTGAACATTGTGAACCAAACCTCGCAATCATCGATTGCTTAA
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| ccrA | Staphylococcus aureus COL |
78.174 |
100 |
0.783 |
| ccrA | Staphylococcus aureus N315 |
72.383 |
100 |
0.725 |