Detailed information NTG0562107

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: KFV25_RS04885
• Genome accession: NZ_CP073900
• Coordinates: 946540..947586 (+)
• Length: 348 a.a.
• NCBI ID: WP_001830374.1
• Uniprot ID: A0A0N1EGU4
• Organism: Staphylococcus epidermidis strain V1949610
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 941540..952586

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
KFV25_RS04860 (KFV25_04860)	-	942681..943217 (+)	537	WP_002470337.1	hypothetical protein	-
KFV25_RS04865 (KFV25_04865)	-	943368..944354 (-)	987	WP_001830388.1	aromatic acid exporter family protein	-
KFV25_RS04870 (KFV25_04870)	map	944528..945283 (+)	756	WP_002457092.1	type I methionyl aminopeptidase	-
KFV25_RS04875 (KFV25_04875)	-	945441..945827 (+)	387	WP_001830382.1	hypothetical protein	-
KFV25_RS04880 (KFV25_04880)	liaF	945842..946543 (+)	702	WP_001830436.1	cell wall-active antibiotics response protein LiaF	-
KFV25_RS04885 (KFV25_04885)	vraS	946540..947586 (+)	1047	WP_001830374.1	sensor histidine kinase	Regulator
KFV25_RS04890 (KFV25_04890)	vraR	947576..948205 (+)	630	WP_001830439.1	two-component system response regulator VraR	Regulator
KFV25_RS04895 (KFV25_04895)	-	948262..949440 (-)	1179	WP_001830411.1	YihY/virulence factor BrkB family protein	-
KFV25_RS04900 (KFV25_04900)	-	949847..950131 (-)	285	WP_001830401.1	YtxH domain-containing protein	-
KFV25_RS04905 (KFV25_04905)	-	950139..950603 (-)	465	WP_001830437.1	low molecular weight protein-tyrosine-phosphatase	-
KFV25_RS04910 (KFV25_04910)	-	950744..950959 (+)	216	WP_001830421.1	DUF1128 domain-containing protein	-
KFV25_RS04915 (KFV25_04915)	-	950961..952202 (+)	1242	WP_001832467.1	aminopeptidase	-

Sequence

Protein

• Length: 348 a.a.
• Molecular weight: 40066.49 Da
• Isoelectric Point: 5.8512

>NTDB_id=562107 KFV25_RS04885 WP_001830374.1 946540..947586(+) (vraS) [Staphylococcus epidermidis strain V1949610]
MNHYIRAIGSMLILVYSMLIAFLFIDKVFVNIIFFQGMFYTQIFGIPVFLFLNLLIVLLCIIVGSVLAYKINQQNDWIIS
QIERSIEGQTVGINDQNIELYTETIDIYHTLVPLNQELHRLRMKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKESKLEPPLNQQIPILEKMVQDSQLEMRALLLHLRPIGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFEVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNQEDYLLLRIQDNGKGFNVDEKFEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEENSSGD

Nucleotide

• Length: 1047 bp

>NTDB_id=562107 KFV25_RS04885 WP_001830374.1 946540..947586(+) (vraS) [Staphylococcus epidermidis strain V1949610]
ATGAATCACTACATAAGAGCTATAGGCTCAATGCTTATATTAGTATATAGTATGCTTATTGCTTTTTTATTTATTGATAA
AGTGTTTGTAAATATTATCTTTTTTCAGGGGATGTTTTATACACAAATATTTGGAATACCTGTTTTTCTATTTTTAAATT
TATTAATTGTTCTTTTATGTATTATAGTTGGATCTGTTTTAGCTTATAAAATTAATCAACAAAATGATTGGATTATTTCA
CAAATAGAAAGATCAATAGAAGGACAAACAGTAGGTATCAATGATCAAAATATCGAATTATATACAGAAACGATAGATAT
TTATCATACACTAGTTCCATTAAATCAAGAATTACATCGACTTAGAATGAAGACTCAAAATTTAACTAATGAAAACTACA
ATATTAATGATGTAAAAGTCAAAAAGATTATCGAAGATGAGCGACAACGACTTGCCAGGGAATTACATGATTCTGTTAGT
CAACAATTATTTGCTGCGAGCATGATGCTATCGGCGATAAAAGAGTCGAAATTAGAACCACCTTTAAATCAACAGATACC
AATTCTTGAAAAAATGGTTCAAGACTCACAACTTGAAATGAGAGCTTTGTTATTACATTTAAGACCGATAGGTTTAAAAG
ATAAGTCTTTAGGTGAAGGAATTAAAGATTTAGTCATCGATTTACAAAAGAAAGTACCAATGAAAGTTGTGCATGAAATT
CAAGATTTTGAAGTGCCAAAAGGCATTGAAGATCACTTGTTCAGAATTACACAAGAAGCTATTTCAAATACATTGAGACA
TTCAAATGGTACAAAAGTAACTGTGGAATTATTTAATCAAGAGGATTATCTTTTACTAAGAATTCAAGATAATGGAAAAG
GGTTTAATGTAGATGAAAAATTTGAACAAAGTTATGGTTTGAAAAATATGCGAGAACGAGCGTTAGAAATTGGTGCGACG
TTTCATATTGTATCTTTACCTGATTCAGGTACACGAATTGAAGTTAAGGCACCATTGAATAAGGAGGAGAATTCAAGTGG
CGATTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0N1EGU4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	93.023	98.851	0.92