Detailed information
Bioinformatically predicted
Overview
| Name | ccrA | Type | Machinery gene |
| Locus tag | KFV53_RS12970 | Genome accession | NZ_CP073881 |
| Coordinates | 2648058..2649419 (+) | Length | 453 a.a. |
| NCBI ID | WP_001631036.1 | Uniprot ID | - |
| Organism | Staphylococcus epidermidis strain B1286247 | ||
| Function | promote SCCmec transfer (predicted from homology) Homologous recombination |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| SCCmec | 2602383..2651044 | 2648058..2649419 | within | 0 |
Gene organization within MGE regions
Location: 2602383..2651044
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KFV53_RS12720 (KFV53_12730) | ccrA | 2602383..2603729 (+) | 1347 | WP_000816499.1 | recombinase family protein | Machinery gene |
| KFV53_RS12725 (KFV53_12735) | ccrB | 2603750..2605378 (+) | 1629 | WP_001186596.1 | recombinase family protein | Machinery gene |
| KFV53_RS12730 (KFV53_12740) | - | 2605849..2606199 (+) | 351 | WP_000171449.1 | SAUGI family uracil-DNA glycosylase inhibitor | - |
| KFV53_RS12735 (KFV53_12745) | - | 2606284..2606595 (+) | 312 | WP_000833212.1 | DUF960 family protein | - |
| KFV53_RS12740 (KFV53_12750) | - | 2606614..2607135 (+) | 522 | WP_000836008.1 | DUF1643 domain-containing protein | - |
| KFV53_RS12745 (KFV53_12755) | - | 2607137..2607343 (+) | 207 | WP_001077283.1 | hypothetical protein | - |
| KFV53_RS12750 (KFV53_12760) | - | 2607336..2607659 (+) | 324 | WP_000088091.1 | JAB domain-containing protein | - |
| KFV53_RS12755 (KFV53_12765) | - | 2607854..2609746 (+) | 1893 | WP_002485298.1 | site-specific integrase | - |
| KFV53_RS12760 (KFV53_12770) | - | 2609753..2610130 (+) | 378 | WP_001041908.1 | DUF6262 family protein | - |
| KFV53_RS12765 (KFV53_12775) | - | 2610368..2610733 (+) | 366 | WP_000159127.1 | metalloregulator ArsR/SmtB family transcription factor | - |
| KFV53_RS12770 (KFV53_12780) | - | 2610726..2613140 (+) | 2415 | WP_000378485.1 | cadmium-translocating P-type ATPase CadA | - |
| KFV53_RS12775 (KFV53_12785) | - | 2613221..2613837 (+) | 617 | Protein_2490 | CadD family cadmium resistance transporter | - |
| KFV53_RS12785 (KFV53_12795) | - | 2614111..2614749 (-) | 639 | Protein_2491 | sulfite exporter TauE/SafE family protein | - |
| KFV53_RS12790 (KFV53_12800) | cstR | 2614749..2615009 (-) | 261 | WP_000220507.1 | persulfide-sensing transcriptional repressor CstR | - |
| KFV53_RS12795 (KFV53_12805) | - | 2615145..2616209 (+) | 1065 | WP_000438836.1 | DsrE/DsrF/DrsH-like family protein | - |
| KFV53_RS12800 (KFV53_12810) | cstB | 2616242..2617576 (+) | 1335 | Protein_2494 | persulfide dioxygenase-sulfurtransferase CstB | - |
| KFV53_RS12805 (KFV53_12815) | - | 2617690..2618820 (-) | 1131 | WP_010922808.1 | ROK family transcriptional regulator | - |
| KFV53_RS12810 (KFV53_12820) | psm-mec | 2619154..2619222 (+) | 69 | WP_014532405.1 | phenol-soluble modulin PSM-mec | - |
| KFV53_RS12815 (KFV53_12825) | mecI | 2619307..2619678 (-) | 372 | WP_000369214.1 | mecA-type methicillin resistance repressor MecI | - |
| KFV53_RS12820 (KFV53_12830) | mecR1 | 2619678..2621435 (-) | 1758 | WP_000952923.1 | beta-lactam sensor/signal transducer MecR1 | - |
| KFV53_RS12825 (KFV53_12835) | mecA | 2621532..2623541 (+) | 2010 | WP_001801873.1 | PBP2a family beta-lactam-resistant peptidoglycan transpeptidase MecA | - |
| KFV53_RS12830 (KFV53_12840) | - | 2623587..2624015 (-) | 429 | WP_000872606.1 | MaoC family dehydratase | - |
| KFV53_RS12835 (KFV53_12845) | - | 2624112..2624855 (-) | 744 | WP_000958858.1 | glycerophosphoryl diester phosphodiesterase | - |
| KFV53_RS12840 (KFV53_12850) | - | 2625652..2626041 (-) | 390 | WP_020444595.1 | hydroxymethylglutaryl-CoA synthase | - |
| KFV53_RS12845 (KFV53_12855) | - | 2626077..2626751 (+) | 675 | WP_001106057.1 | IS6-like element IS257 family transposase | - |
| KFV53_RS12850 (KFV53_12860) | - | 2627196..2628452 (-) | 1257 | WP_000566670.1 | DUF3578 domain-containing protein | - |
| KFV53_RS12855 (KFV53_12865) | - | 2628895..2629440 (-) | 546 | WP_031869236.1 | YdhK family protein | - |
| KFV53_RS12860 (KFV53_12870) | - | 2629458..2629667 (-) | 210 | Protein_2506 | heavy metal translocating P-type ATPase | - |
| KFV53_RS12865 (KFV53_12875) | - | 2629837..2630595 (-) | 759 | WP_000623679.1 | sulfite exporter TauE/SafE family protein | - |
| KFV53_RS12870 (KFV53_12880) | - | 2630592..2630747 (-) | 156 | Protein_2508 | metal-sensing transcriptional repressor | - |
| KFV53_RS12880 (KFV53_12890) | - | 2630970..2631260 (-) | 291 | WP_012086558.1 | hypothetical protein | - |
| KFV53_RS12885 (KFV53_12895) | - | 2631312..2632184 (-) | 873 | WP_012086560.1 | HTH domain-containing protein | - |
| KFV53_RS12890 (KFV53_12900) | - | 2632354..2632800 (-) | 447 | WP_012086562.1 | JAB domain-containing protein | - |
| KFV53_RS12895 (KFV53_12905) | - | 2632828..2633334 (-) | 507 | WP_012086564.1 | DUF1643 domain-containing protein | - |
| KFV53_RS12900 (KFV53_12910) | - | 2633350..2633661 (-) | 312 | WP_001083109.1 | DUF960 family protein | - |
| KFV53_RS12905 (KFV53_12915) | - | 2633757..2634095 (-) | 339 | WP_012086569.1 | SAUGI family uracil-DNA glycosylase inhibitor | - |
| KFV53_RS12910 (KFV53_12920) | - | 2634201..2635877 (-) | 1677 | WP_012086571.1 | recombinase family protein | - |
| KFV53_RS12915 (KFV53_12925) | - | 2636104..2637747 (-) | 1644 | WP_012086574.1 | DUF5906 domain-containing protein | - |
| KFV53_RS12920 (KFV53_12930) | - | 2637744..2638115 (-) | 372 | WP_001058157.1 | hypothetical protein | - |
| KFV53_RS12925 (KFV53_12935) | - | 2638108..2639208 (-) | 1101 | WP_000449985.1 | DNA polymerase | - |
| KFV53_RS12930 (KFV53_12940) | - | 2639435..2640910 (-) | 1476 | WP_001138664.1 | DUF6038 family protein | - |
| KFV53_RS12935 (KFV53_12945) | - | 2641018..2641881 (-) | 864 | WP_000680579.1 | hypothetical protein | - |
| KFV53_RS12940 (KFV53_12950) | - | 2642079..2642384 (-) | 306 | WP_000677987.1 | hypothetical protein | - |
| KFV53_RS12945 (KFV53_12955) | - | 2643636..2645561 (-) | 1926 | WP_002485723.1 | heavy metal translocating P-type ATPase | - |
| KFV53_RS12950 (KFV53_12960) | - | 2645891..2646217 (-) | 327 | WP_000391495.1 | metalloregulator ArsR/SmtB family transcription factor | - |
| KFV53_RS12955 (KFV53_12965) | - | 2646424..2646783 (+) | 360 | WP_001631039.1 | hypothetical protein | - |
| KFV53_RS12960 (KFV53_12970) | - | 2646895..2647233 (-) | 339 | Protein_2525 | recombinase family protein | - |
| KFV53_RS12965 (KFV53_12975) | - | 2647242..2647871 (+) | 630 | Protein_2526 | hypothetical protein | - |
| KFV53_RS12970 (KFV53_12980) | ccrA | 2648058..2649419 (+) | 1362 | WP_001631036.1 | recombinase family protein | Machinery gene |
| KFV53_RS12975 (KFV53_12985) | ccrB | 2649416..2651044 (+) | 1629 | WP_001631035.1 | recombinase family protein | Machinery gene |
Sequence
Protein
Download Length: 453 a.a. Molecular weight: 53316.45 Da Isoelectric Point: 9.8596
>NTDB_id=561866 KFV53_RS12970 WP_001631036.1 2648058..2649419(+) (ccrA) [Staphylococcus epidermidis strain B1286247]
MEEAIAYVRQSTLKQQSLATQKSLIMDTAKQYGWSNVAFYDDKKTGRHTKRSGYQKMVEIITSGKCKVLCCYRLNRLHRN
LKNAIQFFEICKKHHITIISVNDGYFDLSKEFDCFRLNILMSLAEMESNNISEQTKNGIREKAKQGKLITTHAPFGYRYR
KGCFVVQEEEAYTVKSVYRWYLQGLGYKKISQHLDSNPNLIPRKPYQVRNILLNPNYCGRVINKYGTFNDIVPPIIDIDT
FEEAQERRIHKQLNRSNSRNKLKRRIKCPYCQSTLTNLTIKKENYSLRYYVCPKNMNDAYRTCPFKSINAPELESEVLDT
CKKYFEEQSFHKRLNNTILKVLKQQQMKHKETHLTQEQLIEKLAQNRIDVKTFKRLSASCKSEENYSTYSTYQIDDKLKY
VIKNKITLQDIAPFIDCIKITQTKQLQGIYFKNSPLNIVEQSHLITPERNEVI
MEEAIAYVRQSTLKQQSLATQKSLIMDTAKQYGWSNVAFYDDKKTGRHTKRSGYQKMVEIITSGKCKVLCCYRLNRLHRN
LKNAIQFFEICKKHHITIISVNDGYFDLSKEFDCFRLNILMSLAEMESNNISEQTKNGIREKAKQGKLITTHAPFGYRYR
KGCFVVQEEEAYTVKSVYRWYLQGLGYKKISQHLDSNPNLIPRKPYQVRNILLNPNYCGRVINKYGTFNDIVPPIIDIDT
FEEAQERRIHKQLNRSNSRNKLKRRIKCPYCQSTLTNLTIKKENYSLRYYVCPKNMNDAYRTCPFKSINAPELESEVLDT
CKKYFEEQSFHKRLNNTILKVLKQQQMKHKETHLTQEQLIEKLAQNRIDVKTFKRLSASCKSEENYSTYSTYQIDDKLKY
VIKNKITLQDIAPFIDCIKITQTKQLQGIYFKNSPLNIVEQSHLITPERNEVI
Nucleotide
Download Length: 1362 bp
>NTDB_id=561866 KFV53_RS12970 WP_001631036.1 2648058..2649419(+) (ccrA) [Staphylococcus epidermidis strain B1286247]
ATGGAAGAAGCGATTGCTTATGTACGTCAAAGTACACTCAAACAACAAAGCTTAGCTACTCAAAAATCGCTCATTATGGA
TACCGCTAAGCAATATGGATGGTCTAATGTGGCGTTTTATGATGATAAGAAAACAGGTCGACATACAAAACGTTCAGGTT
ATCAAAAAATGGTAGAAATAATTACGTCTGGAAAATGTAAAGTATTGTGTTGCTATCGCTTGAACCGACTACATCGTAAT
TTGAAAAATGCCATACAATTCTTTGAAATTTGTAAAAAGCATCACATCACAATCATCAGTGTTAACGATGGATATTTTGA
TTTGTCTAAAGAGTTTGATTGCTTTCGTTTGAACATACTTATGAGTCTAGCGGAAATGGAATCAAACAATATCAGCGAAC
AAACAAAAAATGGGATTAGAGAAAAAGCCAAACAAGGTAAGCTAATCACAACTCATGCTCCGTTTGGCTATCGTTATAGA
AAAGGTTGTTTTGTTGTACAAGAAGAAGAAGCGTATACAGTTAAATCGGTTTATCGCTGGTACTTACAAGGTCTAGGCTA
CAAAAAGATTTCCCAACATTTGGATAGTAATCCTAACCTTATTCCTCGTAAGCCCTATCAAGTTAGAAATATTCTCTTGA
ACCCTAACTATTGCGGTCGTGTCATCAATAAATATGGCACGTTTAATGATATCGTTCCACCTATTATTGATATTGATACA
TTTGAAGAAGCACAAGAGCGTCGTATTCATAAACAACTCAATCGATCCAATTCTAGAAATAAGCTAAAGCGACGAATCAA
ATGTCCTTACTGTCAATCAACATTAACAAACTTAACGATAAAAAAAGAGAACTATTCTCTACGTTACTATGTTTGTCCTA
AAAATATGAATGACGCTTATCGTACATGCCCATTTAAAAGTATCAATGCACCAGAACTTGAAAGTGAAGTGCTCGACACT
TGTAAAAAGTATTTTGAAGAACAATCGTTTCATAAACGATTGAATAACACAATACTCAAAGTCCTAAAACAGCAACAAAT
GAAGCATAAAGAAACCCATCTAACACAAGAACAACTTATCGAAAAGCTAGCTCAAAATCGTATTGATGTAAAAACGTTCA
AACGTTTATCTGCTAGTTGTAAAAGTGAAGAGAATTACTCTACTTATTCAACCTACCAAATCGATGACAAATTAAAATAT
GTCATAAAAAATAAAATAACTTTACAGGATATAGCACCTTTTATCGATTGCATCAAAATAACTCAAACTAAACAATTACA
AGGAATCTACTTTAAAAACAGTCCACTCAATATCGTTGAACAATCACATTTAATAACTCCTGAAAGGAATGAAGTAATAT
GA
ATGGAAGAAGCGATTGCTTATGTACGTCAAAGTACACTCAAACAACAAAGCTTAGCTACTCAAAAATCGCTCATTATGGA
TACCGCTAAGCAATATGGATGGTCTAATGTGGCGTTTTATGATGATAAGAAAACAGGTCGACATACAAAACGTTCAGGTT
ATCAAAAAATGGTAGAAATAATTACGTCTGGAAAATGTAAAGTATTGTGTTGCTATCGCTTGAACCGACTACATCGTAAT
TTGAAAAATGCCATACAATTCTTTGAAATTTGTAAAAAGCATCACATCACAATCATCAGTGTTAACGATGGATATTTTGA
TTTGTCTAAAGAGTTTGATTGCTTTCGTTTGAACATACTTATGAGTCTAGCGGAAATGGAATCAAACAATATCAGCGAAC
AAACAAAAAATGGGATTAGAGAAAAAGCCAAACAAGGTAAGCTAATCACAACTCATGCTCCGTTTGGCTATCGTTATAGA
AAAGGTTGTTTTGTTGTACAAGAAGAAGAAGCGTATACAGTTAAATCGGTTTATCGCTGGTACTTACAAGGTCTAGGCTA
CAAAAAGATTTCCCAACATTTGGATAGTAATCCTAACCTTATTCCTCGTAAGCCCTATCAAGTTAGAAATATTCTCTTGA
ACCCTAACTATTGCGGTCGTGTCATCAATAAATATGGCACGTTTAATGATATCGTTCCACCTATTATTGATATTGATACA
TTTGAAGAAGCACAAGAGCGTCGTATTCATAAACAACTCAATCGATCCAATTCTAGAAATAAGCTAAAGCGACGAATCAA
ATGTCCTTACTGTCAATCAACATTAACAAACTTAACGATAAAAAAAGAGAACTATTCTCTACGTTACTATGTTTGTCCTA
AAAATATGAATGACGCTTATCGTACATGCCCATTTAAAAGTATCAATGCACCAGAACTTGAAAGTGAAGTGCTCGACACT
TGTAAAAAGTATTTTGAAGAACAATCGTTTCATAAACGATTGAATAACACAATACTCAAAGTCCTAAAACAGCAACAAAT
GAAGCATAAAGAAACCCATCTAACACAAGAACAACTTATCGAAAAGCTAGCTCAAAATCGTATTGATGTAAAAACGTTCA
AACGTTTATCTGCTAGTTGTAAAAGTGAAGAGAATTACTCTACTTATTCAACCTACCAAATCGATGACAAATTAAAATAT
GTCATAAAAAATAAAATAACTTTACAGGATATAGCACCTTTTATCGATTGCATCAAAATAACTCAAACTAAACAATTACA
AGGAATCTACTTTAAAAACAGTCCACTCAATATCGTTGAACAATCACATTTAATAACTCCTGAAAGGAATGAAGTAATAT
GA
3D structure
| Source | ID | Structure |
|---|
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| ccrA | Staphylococcus aureus COL |
54.628 |
97.792 |
0.534 |
| ccrA | Staphylococcus aureus N315 |
50.564 |
97.792 |
0.494 |