Detailed information
Bioinformatically predicted
Overview
| Name | ccrA | Type | Machinery gene |
| Locus tag | KFV29_RS13065 | Genome accession | NZ_CP073878 |
| Coordinates | 2648126..2649487 (+) | Length | 453 a.a. |
| NCBI ID | WP_001631036.1 | Uniprot ID | - |
| Organism | Staphylococcus epidermidis strain B1285228 | ||
| Function | promote SCCmec transfer (predicted from homology) Homologous recombination |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| SCCmec | 2602451..2651112 | 2648126..2649487 | within | 0 |
Gene organization within MGE regions
Location: 2602451..2651112
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KFV29_RS12815 (KFV29_12825) | ccrA | 2602451..2603797 (+) | 1347 | WP_000816499.1 | recombinase family protein | Machinery gene |
| KFV29_RS12820 (KFV29_12830) | ccrB | 2603818..2605446 (+) | 1629 | WP_001186596.1 | recombinase family protein | Machinery gene |
| KFV29_RS12825 (KFV29_12835) | - | 2605917..2606267 (+) | 351 | WP_000171449.1 | SAUGI family uracil-DNA glycosylase inhibitor | - |
| KFV29_RS12830 (KFV29_12840) | - | 2606352..2606663 (+) | 312 | WP_000833212.1 | DUF960 family protein | - |
| KFV29_RS12835 (KFV29_12845) | - | 2606682..2607203 (+) | 522 | WP_000836008.1 | DUF1643 domain-containing protein | - |
| KFV29_RS12840 (KFV29_12850) | - | 2607205..2607411 (+) | 207 | WP_001077283.1 | hypothetical protein | - |
| KFV29_RS12845 (KFV29_12855) | - | 2607404..2607727 (+) | 324 | WP_000088091.1 | JAB domain-containing protein | - |
| KFV29_RS12850 (KFV29_12860) | - | 2607922..2609814 (+) | 1893 | WP_002485298.1 | site-specific integrase | - |
| KFV29_RS12855 (KFV29_12865) | - | 2609821..2610198 (+) | 378 | WP_001041908.1 | DUF6262 family protein | - |
| KFV29_RS12860 (KFV29_12870) | - | 2610436..2610801 (+) | 366 | WP_000159127.1 | metalloregulator ArsR/SmtB family transcription factor | - |
| KFV29_RS12865 (KFV29_12875) | - | 2610794..2613208 (+) | 2415 | WP_000378485.1 | cadmium-translocating P-type ATPase CadA | - |
| KFV29_RS12870 (KFV29_12880) | - | 2613289..2613905 (+) | 617 | Protein_2484 | CadD family cadmium resistance transporter | - |
| KFV29_RS12880 (KFV29_12890) | - | 2614179..2614817 (-) | 639 | Protein_2485 | sulfite exporter TauE/SafE family protein | - |
| KFV29_RS12885 (KFV29_12895) | cstR | 2614817..2615077 (-) | 261 | WP_000220507.1 | persulfide-sensing transcriptional repressor CstR | - |
| KFV29_RS12890 (KFV29_12900) | - | 2615213..2616277 (+) | 1065 | WP_000438836.1 | DsrE/DsrF/DrsH-like family protein | - |
| KFV29_RS12895 (KFV29_12905) | cstB | 2616310..2617644 (+) | 1335 | Protein_2488 | persulfide dioxygenase-sulfurtransferase CstB | - |
| KFV29_RS12900 (KFV29_12910) | - | 2617758..2618867 (-) | 1110 | WP_000943131.1 | ROK family transcriptional regulator | - |
| KFV29_RS12905 (KFV29_12915) | psm-mec | 2619222..2619290 (+) | 69 | WP_014532405.1 | phenol-soluble modulin PSM-mec | - |
| KFV29_RS12910 (KFV29_12920) | mecI | 2619375..2619746 (-) | 372 | WP_000369214.1 | mecA-type methicillin resistance repressor MecI | - |
| KFV29_RS12915 (KFV29_12925) | mecR1 | 2619746..2621503 (-) | 1758 | WP_000952923.1 | beta-lactam sensor/signal transducer MecR1 | - |
| KFV29_RS12920 (KFV29_12930) | mecA | 2621600..2623609 (+) | 2010 | WP_001801873.1 | PBP2a family beta-lactam-resistant peptidoglycan transpeptidase MecA | - |
| KFV29_RS12925 (KFV29_12935) | - | 2623655..2624083 (-) | 429 | WP_000872606.1 | MaoC family dehydratase | - |
| KFV29_RS12930 (KFV29_12940) | - | 2624180..2624923 (-) | 744 | WP_000958858.1 | glycerophosphoryl diester phosphodiesterase | - |
| KFV29_RS12935 (KFV29_12945) | - | 2625720..2626109 (-) | 390 | WP_020444595.1 | hydroxymethylglutaryl-CoA synthase | - |
| KFV29_RS12940 (KFV29_12950) | - | 2626145..2626819 (+) | 675 | WP_001106057.1 | IS6-like element IS257 family transposase | - |
| KFV29_RS12945 (KFV29_12955) | - | 2627264..2628520 (-) | 1257 | WP_000566670.1 | DUF3578 domain-containing protein | - |
| KFV29_RS12950 (KFV29_12960) | - | 2628963..2629508 (-) | 546 | WP_031869236.1 | YdhK family protein | - |
| KFV29_RS12955 (KFV29_12965) | - | 2629526..2629735 (-) | 210 | Protein_2500 | heavy metal translocating P-type ATPase | - |
| KFV29_RS12960 (KFV29_12970) | - | 2629905..2630663 (-) | 759 | WP_000623679.1 | sulfite exporter TauE/SafE family protein | - |
| KFV29_RS12965 (KFV29_12975) | - | 2630660..2630815 (-) | 156 | Protein_2502 | metal-sensing transcriptional repressor | - |
| KFV29_RS12975 (KFV29_12985) | - | 2631038..2631328 (-) | 291 | WP_012086558.1 | hypothetical protein | - |
| KFV29_RS12980 (KFV29_12990) | - | 2631380..2632252 (-) | 873 | WP_012086560.1 | HTH domain-containing protein | - |
| KFV29_RS12985 (KFV29_12995) | - | 2632422..2632868 (-) | 447 | WP_012086562.1 | JAB domain-containing protein | - |
| KFV29_RS12990 (KFV29_13000) | - | 2632896..2633402 (-) | 507 | WP_012086564.1 | DUF1643 domain-containing protein | - |
| KFV29_RS12995 (KFV29_13005) | - | 2633418..2633729 (-) | 312 | WP_001083109.1 | DUF960 family protein | - |
| KFV29_RS13000 (KFV29_13010) | - | 2633825..2634163 (-) | 339 | WP_012086569.1 | SAUGI family uracil-DNA glycosylase inhibitor | - |
| KFV29_RS13005 (KFV29_13015) | - | 2634269..2635945 (-) | 1677 | WP_012086571.1 | recombinase family protein | - |
| KFV29_RS13010 (KFV29_13020) | - | 2636172..2637815 (-) | 1644 | WP_012086574.1 | DUF5906 domain-containing protein | - |
| KFV29_RS13015 (KFV29_13025) | - | 2637812..2638183 (-) | 372 | WP_001058157.1 | hypothetical protein | - |
| KFV29_RS13020 (KFV29_13030) | - | 2638176..2639276 (-) | 1101 | WP_000449985.1 | DNA polymerase | - |
| KFV29_RS13025 (KFV29_13035) | - | 2639503..2640978 (-) | 1476 | WP_001138664.1 | DUF6038 family protein | - |
| KFV29_RS13030 (KFV29_13040) | - | 2641086..2641949 (-) | 864 | WP_000680579.1 | hypothetical protein | - |
| KFV29_RS13035 (KFV29_13045) | - | 2642147..2642452 (-) | 306 | WP_000677987.1 | hypothetical protein | - |
| KFV29_RS13040 (KFV29_13050) | - | 2643704..2645629 (-) | 1926 | WP_002485723.1 | heavy metal translocating P-type ATPase | - |
| KFV29_RS13045 (KFV29_13055) | - | 2645959..2646285 (-) | 327 | WP_000391495.1 | metalloregulator ArsR/SmtB family transcription factor | - |
| KFV29_RS13050 (KFV29_13060) | - | 2646492..2646851 (+) | 360 | WP_001631039.1 | hypothetical protein | - |
| KFV29_RS13055 (KFV29_13065) | - | 2646963..2647301 (-) | 339 | Protein_2519 | recombinase family protein | - |
| KFV29_RS13060 (KFV29_13070) | - | 2647310..2647939 (+) | 630 | Protein_2520 | hypothetical protein | - |
| KFV29_RS13065 (KFV29_13075) | ccrA | 2648126..2649487 (+) | 1362 | WP_001631036.1 | recombinase family protein | Machinery gene |
| KFV29_RS13070 (KFV29_13080) | ccrB | 2649484..2651112 (+) | 1629 | WP_001631035.1 | recombinase family protein | Machinery gene |
Sequence
Protein
Download Length: 453 a.a. Molecular weight: 53316.45 Da Isoelectric Point: 9.8596
>NTDB_id=561828 KFV29_RS13065 WP_001631036.1 2648126..2649487(+) (ccrA) [Staphylococcus epidermidis strain B1285228]
MEEAIAYVRQSTLKQQSLATQKSLIMDTAKQYGWSNVAFYDDKKTGRHTKRSGYQKMVEIITSGKCKVLCCYRLNRLHRN
LKNAIQFFEICKKHHITIISVNDGYFDLSKEFDCFRLNILMSLAEMESNNISEQTKNGIREKAKQGKLITTHAPFGYRYR
KGCFVVQEEEAYTVKSVYRWYLQGLGYKKISQHLDSNPNLIPRKPYQVRNILLNPNYCGRVINKYGTFNDIVPPIIDIDT
FEEAQERRIHKQLNRSNSRNKLKRRIKCPYCQSTLTNLTIKKENYSLRYYVCPKNMNDAYRTCPFKSINAPELESEVLDT
CKKYFEEQSFHKRLNNTILKVLKQQQMKHKETHLTQEQLIEKLAQNRIDVKTFKRLSASCKSEENYSTYSTYQIDDKLKY
VIKNKITLQDIAPFIDCIKITQTKQLQGIYFKNSPLNIVEQSHLITPERNEVI
MEEAIAYVRQSTLKQQSLATQKSLIMDTAKQYGWSNVAFYDDKKTGRHTKRSGYQKMVEIITSGKCKVLCCYRLNRLHRN
LKNAIQFFEICKKHHITIISVNDGYFDLSKEFDCFRLNILMSLAEMESNNISEQTKNGIREKAKQGKLITTHAPFGYRYR
KGCFVVQEEEAYTVKSVYRWYLQGLGYKKISQHLDSNPNLIPRKPYQVRNILLNPNYCGRVINKYGTFNDIVPPIIDIDT
FEEAQERRIHKQLNRSNSRNKLKRRIKCPYCQSTLTNLTIKKENYSLRYYVCPKNMNDAYRTCPFKSINAPELESEVLDT
CKKYFEEQSFHKRLNNTILKVLKQQQMKHKETHLTQEQLIEKLAQNRIDVKTFKRLSASCKSEENYSTYSTYQIDDKLKY
VIKNKITLQDIAPFIDCIKITQTKQLQGIYFKNSPLNIVEQSHLITPERNEVI
Nucleotide
Download Length: 1362 bp
>NTDB_id=561828 KFV29_RS13065 WP_001631036.1 2648126..2649487(+) (ccrA) [Staphylococcus epidermidis strain B1285228]
ATGGAAGAAGCGATTGCTTATGTACGTCAAAGTACACTCAAACAACAAAGCTTAGCTACTCAAAAATCGCTCATTATGGA
TACCGCTAAGCAATATGGATGGTCTAATGTGGCGTTTTATGATGATAAGAAAACAGGTCGACATACAAAACGTTCAGGTT
ATCAAAAAATGGTAGAAATAATTACGTCTGGAAAATGTAAAGTATTGTGTTGCTATCGCTTGAACCGACTACATCGTAAT
TTGAAAAATGCCATACAATTCTTTGAAATTTGTAAAAAGCATCACATCACAATCATCAGTGTTAACGATGGATATTTTGA
TTTGTCTAAAGAGTTTGATTGCTTTCGTTTGAACATACTTATGAGTCTAGCGGAAATGGAATCAAACAATATCAGCGAAC
AAACAAAAAATGGGATTAGAGAAAAAGCCAAACAAGGTAAGCTAATCACAACTCATGCTCCGTTTGGCTATCGTTATAGA
AAAGGTTGTTTTGTTGTACAAGAAGAAGAAGCGTATACAGTTAAATCGGTTTATCGCTGGTACTTACAAGGTCTAGGCTA
CAAAAAGATTTCCCAACATTTGGATAGTAATCCTAACCTTATTCCTCGTAAGCCCTATCAAGTTAGAAATATTCTCTTGA
ACCCTAACTATTGCGGTCGTGTCATCAATAAATATGGCACGTTTAATGATATCGTTCCACCTATTATTGATATTGATACA
TTTGAAGAAGCACAAGAGCGTCGTATTCATAAACAACTCAATCGATCCAATTCTAGAAATAAGCTAAAGCGACGAATCAA
ATGTCCTTACTGTCAATCAACATTAACAAACTTAACGATAAAAAAAGAGAACTATTCTCTACGTTACTATGTTTGTCCTA
AAAATATGAATGACGCTTATCGTACATGCCCATTTAAAAGTATCAATGCACCAGAACTTGAAAGTGAAGTGCTCGACACT
TGTAAAAAGTATTTTGAAGAACAATCGTTTCATAAACGATTGAATAACACAATACTCAAAGTCCTAAAACAGCAACAAAT
GAAGCATAAAGAAACCCATCTAACACAAGAACAACTTATCGAAAAGCTAGCTCAAAATCGTATTGATGTAAAAACGTTCA
AACGTTTATCTGCTAGTTGTAAAAGTGAAGAGAATTACTCTACTTATTCAACCTACCAAATCGATGACAAATTAAAATAT
GTCATAAAAAATAAAATAACTTTACAGGATATAGCACCTTTTATCGATTGCATCAAAATAACTCAAACTAAACAATTACA
AGGAATCTACTTTAAAAACAGTCCACTCAATATCGTTGAACAATCACATTTAATAACTCCTGAAAGGAATGAAGTAATAT
GA
ATGGAAGAAGCGATTGCTTATGTACGTCAAAGTACACTCAAACAACAAAGCTTAGCTACTCAAAAATCGCTCATTATGGA
TACCGCTAAGCAATATGGATGGTCTAATGTGGCGTTTTATGATGATAAGAAAACAGGTCGACATACAAAACGTTCAGGTT
ATCAAAAAATGGTAGAAATAATTACGTCTGGAAAATGTAAAGTATTGTGTTGCTATCGCTTGAACCGACTACATCGTAAT
TTGAAAAATGCCATACAATTCTTTGAAATTTGTAAAAAGCATCACATCACAATCATCAGTGTTAACGATGGATATTTTGA
TTTGTCTAAAGAGTTTGATTGCTTTCGTTTGAACATACTTATGAGTCTAGCGGAAATGGAATCAAACAATATCAGCGAAC
AAACAAAAAATGGGATTAGAGAAAAAGCCAAACAAGGTAAGCTAATCACAACTCATGCTCCGTTTGGCTATCGTTATAGA
AAAGGTTGTTTTGTTGTACAAGAAGAAGAAGCGTATACAGTTAAATCGGTTTATCGCTGGTACTTACAAGGTCTAGGCTA
CAAAAAGATTTCCCAACATTTGGATAGTAATCCTAACCTTATTCCTCGTAAGCCCTATCAAGTTAGAAATATTCTCTTGA
ACCCTAACTATTGCGGTCGTGTCATCAATAAATATGGCACGTTTAATGATATCGTTCCACCTATTATTGATATTGATACA
TTTGAAGAAGCACAAGAGCGTCGTATTCATAAACAACTCAATCGATCCAATTCTAGAAATAAGCTAAAGCGACGAATCAA
ATGTCCTTACTGTCAATCAACATTAACAAACTTAACGATAAAAAAAGAGAACTATTCTCTACGTTACTATGTTTGTCCTA
AAAATATGAATGACGCTTATCGTACATGCCCATTTAAAAGTATCAATGCACCAGAACTTGAAAGTGAAGTGCTCGACACT
TGTAAAAAGTATTTTGAAGAACAATCGTTTCATAAACGATTGAATAACACAATACTCAAAGTCCTAAAACAGCAACAAAT
GAAGCATAAAGAAACCCATCTAACACAAGAACAACTTATCGAAAAGCTAGCTCAAAATCGTATTGATGTAAAAACGTTCA
AACGTTTATCTGCTAGTTGTAAAAGTGAAGAGAATTACTCTACTTATTCAACCTACCAAATCGATGACAAATTAAAATAT
GTCATAAAAAATAAAATAACTTTACAGGATATAGCACCTTTTATCGATTGCATCAAAATAACTCAAACTAAACAATTACA
AGGAATCTACTTTAAAAACAGTCCACTCAATATCGTTGAACAATCACATTTAATAACTCCTGAAAGGAATGAAGTAATAT
GA
3D structure
| Source | ID | Structure |
|---|
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| ccrA | Staphylococcus aureus COL |
54.628 |
97.792 |
0.534 |
| ccrA | Staphylococcus aureus N315 |
50.564 |
97.792 |
0.494 |