Detailed information
Bioinformatically predicted
Overview
| Name | ccrB | Type | Machinery gene |
| Locus tag | KFV35_RS00605 | Genome accession | NZ_CP073865 |
| Coordinates | 138451..140079 (+) | Length | 542 a.a. |
| NCBI ID | WP_001186596.1 | Uniprot ID | - |
| Organism | Staphylococcus epidermidis strain B1276912 | ||
| Function | promote SCCmec transfer (predicted from homology) Homologous recombination |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| SCCmec | 137084..185745 | 138451..140079 | within | 0 |
Gene organization within MGE regions
Location: 137084..185745
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KFV35_RS00600 (KFV35_00640) | ccrA | 137084..138430 (+) | 1347 | WP_000816499.1 | recombinase family protein | Machinery gene |
| KFV35_RS00605 (KFV35_00645) | ccrB | 138451..140079 (+) | 1629 | WP_001186596.1 | recombinase family protein | Machinery gene |
| KFV35_RS00610 (KFV35_00650) | - | 140550..140900 (+) | 351 | WP_000171449.1 | SAUGI family uracil-DNA glycosylase inhibitor | - |
| KFV35_RS00615 (KFV35_00655) | - | 140985..141296 (+) | 312 | WP_000833212.1 | DUF960 family protein | - |
| KFV35_RS00620 (KFV35_00660) | - | 141315..141836 (+) | 522 | WP_000836008.1 | DUF1643 domain-containing protein | - |
| KFV35_RS00625 (KFV35_00665) | - | 141838..142044 (+) | 207 | WP_001077283.1 | hypothetical protein | - |
| KFV35_RS00630 (KFV35_00670) | - | 142037..142360 (+) | 324 | WP_000088091.1 | JAB domain-containing protein | - |
| KFV35_RS00635 (KFV35_00675) | - | 142555..144447 (+) | 1893 | WP_002485298.1 | site-specific integrase | - |
| KFV35_RS00640 (KFV35_00680) | - | 144454..144831 (+) | 378 | WP_001041908.1 | DUF6262 family protein | - |
| KFV35_RS00645 (KFV35_00685) | - | 145069..145434 (+) | 366 | WP_000159127.1 | metalloregulator ArsR/SmtB family transcription factor | - |
| KFV35_RS00650 (KFV35_00690) | - | 145427..147841 (+) | 2415 | WP_000378485.1 | cadmium-translocating P-type ATPase CadA | - |
| KFV35_RS00655 (KFV35_00695) | - | 147922..148538 (+) | 617 | Protein_136 | CadD family cadmium resistance transporter | - |
| KFV35_RS00665 (KFV35_00705) | - | 148812..149450 (-) | 639 | Protein_137 | sulfite exporter TauE/SafE family protein | - |
| KFV35_RS00670 (KFV35_00710) | cstR | 149450..149710 (-) | 261 | WP_000220507.1 | persulfide-sensing transcriptional repressor CstR | - |
| KFV35_RS00675 (KFV35_00715) | - | 149846..150910 (+) | 1065 | WP_000438836.1 | DsrE/DsrF/DrsH-like family protein | - |
| KFV35_RS00680 (KFV35_00720) | cstB | 150943..152277 (+) | 1335 | Protein_140 | persulfide dioxygenase-sulfurtransferase CstB | - |
| KFV35_RS00685 (KFV35_00725) | - | 152391..153521 (-) | 1131 | WP_010922808.1 | ROK family transcriptional regulator | - |
| KFV35_RS00690 (KFV35_00730) | psm-mec | 153855..153923 (+) | 69 | WP_014532405.1 | phenol-soluble modulin PSM-mec | - |
| KFV35_RS00695 (KFV35_00735) | mecI | 154008..154379 (-) | 372 | WP_000369214.1 | mecA-type methicillin resistance repressor MecI | - |
| KFV35_RS00700 (KFV35_00740) | mecR1 | 154379..156136 (-) | 1758 | WP_000952923.1 | beta-lactam sensor/signal transducer MecR1 | - |
| KFV35_RS00705 (KFV35_00745) | mecA | 156233..158242 (+) | 2010 | WP_001801873.1 | PBP2a family beta-lactam-resistant peptidoglycan transpeptidase MecA | - |
| KFV35_RS00710 (KFV35_00750) | - | 158288..158716 (-) | 429 | WP_000872606.1 | MaoC family dehydratase | - |
| KFV35_RS00715 (KFV35_00755) | - | 158813..159556 (-) | 744 | WP_000958858.1 | glycerophosphoryl diester phosphodiesterase | - |
| KFV35_RS00720 (KFV35_00760) | - | 160353..160742 (-) | 390 | WP_020444595.1 | hydroxymethylglutaryl-CoA synthase | - |
| KFV35_RS00725 (KFV35_00765) | - | 160778..161452 (+) | 675 | WP_001106057.1 | IS6-like element IS257 family transposase | - |
| KFV35_RS00730 (KFV35_00770) | - | 161897..163153 (-) | 1257 | WP_000566670.1 | DUF3578 domain-containing protein | - |
| KFV35_RS00735 (KFV35_00775) | - | 163596..164141 (-) | 546 | WP_031869236.1 | YdhK family protein | - |
| KFV35_RS00740 (KFV35_00780) | - | 164159..164368 (-) | 210 | Protein_152 | heavy metal translocating P-type ATPase | - |
| KFV35_RS00745 (KFV35_00785) | - | 164538..165296 (-) | 759 | WP_000623679.1 | sulfite exporter TauE/SafE family protein | - |
| KFV35_RS00750 (KFV35_00790) | - | 165293..165448 (-) | 156 | Protein_154 | metal-sensing transcriptional repressor | - |
| KFV35_RS00760 (KFV35_00800) | - | 165671..165961 (-) | 291 | WP_012086558.1 | hypothetical protein | - |
| KFV35_RS00765 (KFV35_00805) | - | 166013..166885 (-) | 873 | WP_012086560.1 | HTH domain-containing protein | - |
| KFV35_RS00770 (KFV35_00810) | - | 167055..167501 (-) | 447 | WP_012086562.1 | JAB domain-containing protein | - |
| KFV35_RS00775 (KFV35_00815) | - | 167529..168035 (-) | 507 | WP_012086564.1 | DUF1643 domain-containing protein | - |
| KFV35_RS00780 (KFV35_00820) | - | 168051..168362 (-) | 312 | WP_001083109.1 | DUF960 family protein | - |
| KFV35_RS00785 (KFV35_00825) | - | 168458..168796 (-) | 339 | WP_012086569.1 | SAUGI family uracil-DNA glycosylase inhibitor | - |
| KFV35_RS00790 (KFV35_00830) | - | 168902..170578 (-) | 1677 | WP_012086571.1 | recombinase family protein | - |
| KFV35_RS00795 (KFV35_00835) | - | 170805..172448 (-) | 1644 | WP_012086574.1 | DUF5906 domain-containing protein | - |
| KFV35_RS00800 (KFV35_00840) | - | 172445..172816 (-) | 372 | WP_001058157.1 | hypothetical protein | - |
| KFV35_RS00805 (KFV35_00845) | - | 172809..173909 (-) | 1101 | WP_000449985.1 | DNA polymerase | - |
| KFV35_RS00810 (KFV35_00850) | - | 174136..175611 (-) | 1476 | WP_001138664.1 | DUF6038 family protein | - |
| KFV35_RS00815 (KFV35_00855) | - | 175719..176582 (-) | 864 | WP_000680579.1 | hypothetical protein | - |
| KFV35_RS00820 (KFV35_00860) | - | 176780..177085 (-) | 306 | WP_000677987.1 | hypothetical protein | - |
| KFV35_RS00825 (KFV35_00865) | - | 178337..180262 (-) | 1926 | WP_002485723.1 | heavy metal translocating P-type ATPase | - |
| KFV35_RS00830 (KFV35_00870) | - | 180592..180918 (-) | 327 | WP_000391495.1 | metalloregulator ArsR/SmtB family transcription factor | - |
| KFV35_RS00835 (KFV35_00875) | - | 181125..181484 (+) | 360 | WP_001631039.1 | hypothetical protein | - |
| KFV35_RS00840 (KFV35_00880) | - | 181596..181934 (-) | 339 | Protein_171 | recombinase family protein | - |
| KFV35_RS00845 (KFV35_00885) | - | 181943..182572 (+) | 630 | Protein_172 | hypothetical protein | - |
| KFV35_RS00850 (KFV35_00890) | ccrA | 182759..184120 (+) | 1362 | WP_001631036.1 | recombinase family protein | Machinery gene |
| KFV35_RS00855 (KFV35_00895) | ccrB | 184117..185745 (+) | 1629 | WP_001631035.1 | recombinase family protein | Machinery gene |
Sequence
Protein
Download Length: 542 a.a. Molecular weight: 62274.15 Da Isoelectric Point: 9.7334
>NTDB_id=561643 KFV35_RS00605 WP_001186596.1 138451..140079(+) (ccrB) [Staphylococcus epidermidis strain B1276912]
MQQLKQKRVGIYVRVSTEIQSTEGYSIDGQINQIREYCDFNNFVVVDVYADRGISGKSMNRPELQRLLKDANEGQIDSVM
VYKTNRLARNTSDLLKIVEDLHRQNVEFFSLSERMEVNTSSGKLMLQILASFSEFERNNIVENVFMGQTRRAQEGYYQGN
LPLGYDKIPDSKHELMINQHEANIVKYIFESYAKGHGYRKIANALNHKGYVTKKGKPFSIGSVTYILSNPFYVGKIQFAK
YKDWNEKRRKGLNDKPIIAEGKHSPIIIQDLWDKVQLRKKQVSQKPQVHGKGTNLLTGIVHCPQCGAPMAASNTTNTLKD
GTKKRIRYYSCSNFRNKGSKVCSANSVRADVIEKYVMDQILEIVKSDKVINQVLERVNQENKVDIGALNHDIAYKQQQYD
EVSGKLHNLVKTIEDNPDLTSALKATIHQYETQLNDITNQMNQLKQQQNQEKLSYDTKQIAALLQRIFQNIESMDKAQLK
ALYLTVIDRIDIRKDGNHKKQFYVTLKLNNEIIKQLFNNTPLDEVLLSTSSLFLPQTLFLQI
MQQLKQKRVGIYVRVSTEIQSTEGYSIDGQINQIREYCDFNNFVVVDVYADRGISGKSMNRPELQRLLKDANEGQIDSVM
VYKTNRLARNTSDLLKIVEDLHRQNVEFFSLSERMEVNTSSGKLMLQILASFSEFERNNIVENVFMGQTRRAQEGYYQGN
LPLGYDKIPDSKHELMINQHEANIVKYIFESYAKGHGYRKIANALNHKGYVTKKGKPFSIGSVTYILSNPFYVGKIQFAK
YKDWNEKRRKGLNDKPIIAEGKHSPIIIQDLWDKVQLRKKQVSQKPQVHGKGTNLLTGIVHCPQCGAPMAASNTTNTLKD
GTKKRIRYYSCSNFRNKGSKVCSANSVRADVIEKYVMDQILEIVKSDKVINQVLERVNQENKVDIGALNHDIAYKQQQYD
EVSGKLHNLVKTIEDNPDLTSALKATIHQYETQLNDITNQMNQLKQQQNQEKLSYDTKQIAALLQRIFQNIESMDKAQLK
ALYLTVIDRIDIRKDGNHKKQFYVTLKLNNEIIKQLFNNTPLDEVLLSTSSLFLPQTLFLQI
Nucleotide
Download Length: 1629 bp
>NTDB_id=561643 KFV35_RS00605 WP_001186596.1 138451..140079(+) (ccrB) [Staphylococcus epidermidis strain B1276912]
ATGCAACAACTCAAACAAAAACGTGTCGGTATCTATGTTCGTGTATCAACGGAAATCCAAAGTACTGAAGGCTATAGTAT
CGATGGACAAATCAATCAAATTCGAGAATATTGTGATTTCAATAACTTTGTTGTTGTAGATGTATACGCGGATAGAGGTA
TCTCTGGAAAATCTATGAACCGACCAGAACTACAACGTTTGTTAAAAGATGCGAACGAAGGTCAGATTGATTCTGTTATG
GTCTACAAAACAAACCGACTAGCACGTAACACTTCTGACTTACTCAAAATTGTTGAAGACCTTCATCGTCAAAATGTCGA
ATTCTTCAGCTTATCTGAGCGTATGGAAGTCAATACAAGCAGTGGTAAATTGATGCTACAAATTCTAGCGAGTTTTTCAG
AATTTGAAAGAAATAATATTGTCGAAAATGTATTCATGGGTCAAACCCGACGCGCTCAAGAAGGCTATTATCAAGGCAAT
TTGCCGCTGGGCTATGACAAAATACCGGATAGCAAGCATGAACTCATGATAAACCAACATGAAGCGAATATTGTCAAATA
TATATTTGAGTCATATGCTAAAGGCCACGGATATCGTAAAATTGCGAATGCACTCAATCACAAAGGATACGTGACTAAAA
AAGGAAAGCCTTTCAGTATTGGTTCAGTGACCTATATCTTATCTAATCCATTCTATGTTGGTAAAATTCAATTCGCAAAG
TACAAAGATTGGAATGAAAAGCGTCGTAAAGGGCTGAATGATAAACCAATAATAGCTGAAGGTAAGCATTCCCCTATTAT
TATTCAAGACTTATGGGATAAAGTCCAATTACGTAAAAAACAAGTCAGTCAAAAACCTCAAGTCCACGGTAAAGGAACTA
ATCTATTAACAGGTATCGTTCATTGTCCACAATGTGGTGCACCAATGGCAGCTAGTAACACAACGAACACATTGAAAGAT
GGTACCAAGAAGCGAATACGTTATTATTCTTGCAGTAACTTCCGAAACAAAGGCTCAAAAGTATGTTCTGCGAATAGCGT
TAGAGCTGATGTGATTGAGAAATACGTCATGGATCAAATACTCGAAATTGTCAAAAGTGATAAAGTCATTAACCAAGTCT
TAGAACGTGTCAATCAAGAAAATAAAGTCGATATTGGTGCATTGAACCACGATATCGCTTATAAACAACAACAATACGAT
GAAGTCAGCGGGAAACTCCATAATTTAGTTAAAACCATTGAAGATAATCCGGACCTAACATCTGCATTGAAAGCAACTAT
TCATCAATATGAAACACAACTCAATGACATTACAAATCAAATGAATCAACTCAAACAGCAACAAAATCAAGAGAAACTAT
CTTATGATACGAAACAAATCGCTGCCCTATTACAACGAATATTTCAAAATATAGAATCAATGGATAAAGCACAACTCAAA
GCATTATATCTTACAGTCATTGACCGTATTGATATTCGTAAAGACGGTAATCATAAAAAACAGTTCTACGTTACACTAAA
ACTCAATAATGAAATTATTAAACAACTTTTCAATAATACCCCTCTCGACGAAGTGCTCCTCAGCACTTCGTCTTTATTTT
TGCCTCAAACGCTCTTTCTTCAAATCTAA
ATGCAACAACTCAAACAAAAACGTGTCGGTATCTATGTTCGTGTATCAACGGAAATCCAAAGTACTGAAGGCTATAGTAT
CGATGGACAAATCAATCAAATTCGAGAATATTGTGATTTCAATAACTTTGTTGTTGTAGATGTATACGCGGATAGAGGTA
TCTCTGGAAAATCTATGAACCGACCAGAACTACAACGTTTGTTAAAAGATGCGAACGAAGGTCAGATTGATTCTGTTATG
GTCTACAAAACAAACCGACTAGCACGTAACACTTCTGACTTACTCAAAATTGTTGAAGACCTTCATCGTCAAAATGTCGA
ATTCTTCAGCTTATCTGAGCGTATGGAAGTCAATACAAGCAGTGGTAAATTGATGCTACAAATTCTAGCGAGTTTTTCAG
AATTTGAAAGAAATAATATTGTCGAAAATGTATTCATGGGTCAAACCCGACGCGCTCAAGAAGGCTATTATCAAGGCAAT
TTGCCGCTGGGCTATGACAAAATACCGGATAGCAAGCATGAACTCATGATAAACCAACATGAAGCGAATATTGTCAAATA
TATATTTGAGTCATATGCTAAAGGCCACGGATATCGTAAAATTGCGAATGCACTCAATCACAAAGGATACGTGACTAAAA
AAGGAAAGCCTTTCAGTATTGGTTCAGTGACCTATATCTTATCTAATCCATTCTATGTTGGTAAAATTCAATTCGCAAAG
TACAAAGATTGGAATGAAAAGCGTCGTAAAGGGCTGAATGATAAACCAATAATAGCTGAAGGTAAGCATTCCCCTATTAT
TATTCAAGACTTATGGGATAAAGTCCAATTACGTAAAAAACAAGTCAGTCAAAAACCTCAAGTCCACGGTAAAGGAACTA
ATCTATTAACAGGTATCGTTCATTGTCCACAATGTGGTGCACCAATGGCAGCTAGTAACACAACGAACACATTGAAAGAT
GGTACCAAGAAGCGAATACGTTATTATTCTTGCAGTAACTTCCGAAACAAAGGCTCAAAAGTATGTTCTGCGAATAGCGT
TAGAGCTGATGTGATTGAGAAATACGTCATGGATCAAATACTCGAAATTGTCAAAAGTGATAAAGTCATTAACCAAGTCT
TAGAACGTGTCAATCAAGAAAATAAAGTCGATATTGGTGCATTGAACCACGATATCGCTTATAAACAACAACAATACGAT
GAAGTCAGCGGGAAACTCCATAATTTAGTTAAAACCATTGAAGATAATCCGGACCTAACATCTGCATTGAAAGCAACTAT
TCATCAATATGAAACACAACTCAATGACATTACAAATCAAATGAATCAACTCAAACAGCAACAAAATCAAGAGAAACTAT
CTTATGATACGAAACAAATCGCTGCCCTATTACAACGAATATTTCAAAATATAGAATCAATGGATAAAGCACAACTCAAA
GCATTATATCTTACAGTCATTGACCGTATTGATATTCGTAAAGACGGTAATCATAAAAAACAGTTCTACGTTACACTAAA
ACTCAATAATGAAATTATTAAACAACTTTTCAATAATACCCCTCTCGACGAAGTGCTCCTCAGCACTTCGTCTTTATTTT
TGCCTCAAACGCTCTTTCTTCAAATCTAA
3D structure
| Source | ID | Structure |
|---|
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| ccrB | Staphylococcus aureus N315 |
86.531 |
100 |
0.865 |