Detailed information
Bioinformatically predicted
Overview
| Name | ccrB | Type | Machinery gene |
| Locus tag | KFV46_RS00280 | Genome accession | NZ_CP073863 |
| Coordinates | 64811..66439 (-) | Length | 542 a.a. |
| NCBI ID | WP_001631035.1 | Uniprot ID | - |
| Organism | Staphylococcus epidermidis strain B1276296 | ||
| Function | promote SCCmec transfer (predicted from homology) Homologous recombination |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| SCCmec | 64811..113472 | 64811..66439 | within | 0 |
Gene organization within MGE regions
Location: 64811..113472
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KFV46_RS00280 (KFV46_00280) | ccrB | 64811..66439 (-) | 1629 | WP_001631035.1 | recombinase family protein | Machinery gene |
| KFV46_RS00285 (KFV46_00285) | ccrA | 66436..67797 (-) | 1362 | WP_001631036.1 | recombinase family protein | Machinery gene |
| KFV46_RS00290 (KFV46_00290) | - | 67984..68613 (-) | 630 | Protein_55 | hypothetical protein | - |
| KFV46_RS00295 (KFV46_00295) | - | 68622..68960 (+) | 339 | Protein_56 | recombinase family protein | - |
| KFV46_RS00300 (KFV46_00300) | - | 69072..69431 (-) | 360 | WP_001631039.1 | hypothetical protein | - |
| KFV46_RS00305 (KFV46_00305) | - | 69638..69964 (+) | 327 | WP_000391495.1 | metalloregulator ArsR/SmtB family transcription factor | - |
| KFV46_RS00310 (KFV46_00310) | - | 70294..72219 (+) | 1926 | WP_002485723.1 | heavy metal translocating P-type ATPase | - |
| KFV46_RS00315 (KFV46_00315) | - | 73471..73776 (+) | 306 | WP_000677987.1 | hypothetical protein | - |
| KFV46_RS00320 (KFV46_00320) | - | 73974..74837 (+) | 864 | WP_000680579.1 | hypothetical protein | - |
| KFV46_RS00325 (KFV46_00325) | - | 74945..76420 (+) | 1476 | WP_001138664.1 | DUF6038 family protein | - |
| KFV46_RS00330 (KFV46_00330) | - | 76647..77747 (+) | 1101 | WP_000449985.1 | DNA polymerase | - |
| KFV46_RS00335 (KFV46_00335) | - | 77740..78111 (+) | 372 | WP_001058157.1 | hypothetical protein | - |
| KFV46_RS00340 (KFV46_00340) | - | 78108..79751 (+) | 1644 | WP_012086574.1 | DUF5906 domain-containing protein | - |
| KFV46_RS00345 (KFV46_00345) | - | 79978..81654 (+) | 1677 | WP_012086571.1 | recombinase family protein | - |
| KFV46_RS00350 (KFV46_00350) | - | 81760..82098 (+) | 339 | WP_012086569.1 | SAUGI family uracil-DNA glycosylase inhibitor | - |
| KFV46_RS00355 (KFV46_00355) | - | 82194..82505 (+) | 312 | WP_001083109.1 | DUF960 family protein | - |
| KFV46_RS00360 (KFV46_00360) | - | 82521..83027 (+) | 507 | WP_012086564.1 | DUF1643 domain-containing protein | - |
| KFV46_RS00365 (KFV46_00365) | - | 83055..83501 (+) | 447 | WP_012086562.1 | JAB domain-containing protein | - |
| KFV46_RS00370 (KFV46_00370) | - | 83671..84543 (+) | 873 | WP_012086560.1 | HTH domain-containing protein | - |
| KFV46_RS00375 (KFV46_00375) | - | 84595..84885 (+) | 291 | WP_012086558.1 | hypothetical protein | - |
| KFV46_RS00385 (KFV46_00385) | - | 85108..85263 (+) | 156 | Protein_73 | metal-sensing transcriptional repressor | - |
| KFV46_RS00390 (KFV46_00390) | - | 85260..86018 (+) | 759 | WP_000623679.1 | sulfite exporter TauE/SafE family protein | - |
| KFV46_RS00395 (KFV46_00395) | - | 86188..86397 (+) | 210 | Protein_75 | heavy metal translocating P-type ATPase | - |
| KFV46_RS00400 (KFV46_00400) | - | 86415..86960 (+) | 546 | WP_031869236.1 | YdhK family protein | - |
| KFV46_RS00405 (KFV46_00405) | - | 87403..88659 (+) | 1257 | WP_000566670.1 | DUF3578 domain-containing protein | - |
| KFV46_RS00410 (KFV46_00410) | - | 89104..89778 (-) | 675 | WP_001106057.1 | IS6-like element IS257 family transposase | - |
| KFV46_RS00415 (KFV46_00415) | - | 89862..90203 (+) | 342 | WP_001797647.1 | hydroxymethylglutaryl-CoA synthase | - |
| KFV46_RS00420 (KFV46_00420) | - | 91000..91743 (+) | 744 | WP_000958858.1 | glycerophosphoryl diester phosphodiesterase | - |
| KFV46_RS00425 (KFV46_00425) | - | 91840..92268 (+) | 429 | WP_000872606.1 | MaoC family dehydratase | - |
| KFV46_RS00430 (KFV46_00430) | mecA | 92314..94323 (-) | 2010 | WP_001801873.1 | PBP2a family beta-lactam-resistant peptidoglycan transpeptidase MecA | - |
| KFV46_RS00435 (KFV46_00435) | mecR1 | 94420..96177 (+) | 1758 | WP_000952923.1 | beta-lactam sensor/signal transducer MecR1 | - |
| KFV46_RS00440 (KFV46_00440) | mecI | 96177..96548 (+) | 372 | WP_000369214.1 | mecA-type methicillin resistance repressor MecI | - |
| KFV46_RS00445 (KFV46_00445) | psm-mec | 96633..96701 (-) | 69 | WP_014532405.1 | phenol-soluble modulin PSM-mec | - |
| KFV46_RS00450 (KFV46_00450) | - | 97035..98165 (+) | 1131 | WP_010922808.1 | ROK family transcriptional regulator | - |
| KFV46_RS00455 (KFV46_00455) | cstB | 98279..99613 (-) | 1335 | Protein_87 | persulfide dioxygenase-sulfurtransferase CstB | - |
| KFV46_RS00460 (KFV46_00460) | - | 99646..100710 (-) | 1065 | WP_000438836.1 | DsrE/DsrF/DrsH-like family protein | - |
| KFV46_RS00465 (KFV46_00465) | cstR | 100846..101106 (+) | 261 | WP_000220507.1 | persulfide-sensing transcriptional repressor CstR | - |
| KFV46_RS00470 (KFV46_00470) | - | 101106..101744 (+) | 639 | Protein_90 | sulfite exporter TauE/SafE family protein | - |
| KFV46_RS00480 (KFV46_00480) | - | 102018..102634 (-) | 617 | Protein_91 | CadD family cadmium resistance transporter | - |
| KFV46_RS00485 (KFV46_00485) | - | 102715..105129 (-) | 2415 | WP_000378485.1 | cadmium-translocating P-type ATPase CadA | - |
| KFV46_RS00490 (KFV46_00490) | - | 105122..105487 (-) | 366 | WP_000159127.1 | metalloregulator ArsR/SmtB family transcription factor | - |
| KFV46_RS00495 (KFV46_00495) | - | 105725..106102 (-) | 378 | WP_001041908.1 | DUF6262 family protein | - |
| KFV46_RS00500 (KFV46_00500) | - | 106109..108001 (-) | 1893 | WP_002485298.1 | site-specific integrase | - |
| KFV46_RS00505 (KFV46_00505) | - | 108196..108519 (-) | 324 | WP_000088091.1 | JAB domain-containing protein | - |
| KFV46_RS00510 (KFV46_00510) | - | 108512..108718 (-) | 207 | WP_001077283.1 | hypothetical protein | - |
| KFV46_RS00515 (KFV46_00515) | - | 108720..109241 (-) | 522 | WP_000836008.1 | DUF1643 domain-containing protein | - |
| KFV46_RS00520 (KFV46_00520) | - | 109260..109571 (-) | 312 | WP_000833212.1 | DUF960 family protein | - |
| KFV46_RS00525 (KFV46_00525) | - | 109656..110006 (-) | 351 | WP_000171449.1 | SAUGI family uracil-DNA glycosylase inhibitor | - |
| KFV46_RS00530 (KFV46_00530) | ccrB | 110477..112105 (-) | 1629 | WP_001186596.1 | recombinase family protein | Machinery gene |
| KFV46_RS00535 (KFV46_00535) | ccrA | 112126..113472 (-) | 1347 | WP_000816499.1 | recombinase family protein | Machinery gene |
Sequence
Protein
Download Length: 542 a.a. Molecular weight: 62474.71 Da Isoelectric Point: 9.6103
>NTDB_id=561607 KFV46_RS00280 WP_001631035.1 64811..66439(-) (ccrB) [Staphylococcus epidermidis strain B1276296]
MKQLKKKRIGLYARVSTEMQTDGYSIQGQLNQLTEYCQFQGYEVVNEYTDRGISGKTMQRPELQRMLKDANEGKLDCIMV
YKTNRLARNTSDLLNIVEELYKINVEFFSLTEKIEIASSTGKLMLQILASFAEFERNTIVENVYNGQRQRAIEGYYQGNL
PLGYDKVPDSKKELMINQHEANIVKYIFDSYAKGHGYRKIANALNHKGYVTKKGKPFSISSITYIISNPFYIGKIQFAKY
RHWSDKRRKGLNEEPIIADGKHAPIIDRNLWDKVQFKRQESRKKPQVHGKGTNLLTGIVKCPKCGAAMAASNTTNTLKDG
TKKRIRYYSCSNFRNKGSKVCSANSVRADVLEKYVMDQILEIIKSKKVLKQLVEKVNEKSQIDVSSLNHDIAYKQSQCEE
IKAKMHTLTKTIEDSPDLDSVLKPTILSYQDELNQINNQIYQLEQDKQAEAPHYDADMIANVLQAIFKDIDKLEKSQLKS
LYLTIIDRIDIRKDEHHKKQFYVTLKLNNDIIKQLFNNHPLDEVLPSTSSLFLPQTLYITIE
MKQLKKKRIGLYARVSTEMQTDGYSIQGQLNQLTEYCQFQGYEVVNEYTDRGISGKTMQRPELQRMLKDANEGKLDCIMV
YKTNRLARNTSDLLNIVEELYKINVEFFSLTEKIEIASSTGKLMLQILASFAEFERNTIVENVYNGQRQRAIEGYYQGNL
PLGYDKVPDSKKELMINQHEANIVKYIFDSYAKGHGYRKIANALNHKGYVTKKGKPFSISSITYIISNPFYIGKIQFAKY
RHWSDKRRKGLNEEPIIADGKHAPIIDRNLWDKVQFKRQESRKKPQVHGKGTNLLTGIVKCPKCGAAMAASNTTNTLKDG
TKKRIRYYSCSNFRNKGSKVCSANSVRADVLEKYVMDQILEIIKSKKVLKQLVEKVNEKSQIDVSSLNHDIAYKQSQCEE
IKAKMHTLTKTIEDSPDLDSVLKPTILSYQDELNQINNQIYQLEQDKQAEAPHYDADMIANVLQAIFKDIDKLEKSQLKS
LYLTIIDRIDIRKDEHHKKQFYVTLKLNNDIIKQLFNNHPLDEVLPSTSSLFLPQTLYITIE
Nucleotide
Download Length: 1629 bp
>NTDB_id=561607 KFV46_RS00280 WP_001631035.1 64811..66439(-) (ccrB) [Staphylococcus epidermidis strain B1276296]
ATGAAACAACTCAAAAAGAAACGTATTGGATTATATGCACGTGTATCGACTGAAATGCAAACGGATGGTTACAGTATTCA
AGGTCAATTGAATCAACTTACAGAGTATTGTCAATTTCAAGGCTATGAAGTCGTCAATGAATACACCGATCGTGGTATAT
CAGGTAAAACAATGCAACGTCCAGAATTACAACGTATGTTAAAAGATGCCAACGAAGGTAAATTAGATTGTATTATGGTC
TACAAAACAAATCGTTTAGCTAGAAATACCTCAGATTTGTTAAATATTGTCGAGGAATTGTATAAGATTAATGTCGAATT
TTTTAGTCTAACTGAAAAAATAGAAATTGCCAGTTCAACAGGTAAATTGATGCTCCAAATTTTAGCCAGCTTCGCAGAAT
TTGAACGTAATACGATTGTAGAGAATGTCTACAATGGCCAAAGACAACGTGCTATTGAAGGTTATTATCAAGGTAATTTA
CCTCTAGGCTACGATAAAGTACCTGACAGTAAAAAAGAGCTCATGATCAATCAACATGAAGCGAATATTGTTAAATATAT
TTTTGATTCATACGCTAAAGGTCATGGTTATCGTAAGATTGCGAACGCATTGAATCATAAAGGTTATGTGACTAAGAAAG
GGAAACCTTTTAGTATTTCGTCCATTACCTACATCATCTCAAACCCTTTTTACATTGGAAAGATACAGTTTGCGAAGTAT
AGACACTGGAGCGATAAAAGACGAAAAGGACTCAATGAGGAACCGATTATCGCTGATGGTAAACATGCGCCTATTATTGA
TAGAAACCTATGGGATAAAGTACAGTTTAAACGTCAAGAGAGTCGCAAGAAACCACAAGTTCACGGCAAAGGAACAAACC
TACTGACTGGGATTGTAAAATGTCCGAAATGTGGTGCAGCAATGGCGGCAAGTAATACAACTAATACATTAAAAGATGGC
ACTAAGAAAAGAATCAGATATTACTCATGTAGCAATTTTAGAAATAAAGGTTCAAAAGTTTGTTCTGCCAATAGCGTTAG
AGCAGATGTACTAGAAAAATATGTTATGGATCAGATATTGGAAATTATCAAAAGCAAAAAGGTATTGAAGCAATTGGTTG
AAAAGGTAAATGAAAAAAGTCAAATAGACGTCTCTTCTTTGAACCATGATATTGCCTATAAACAGTCACAATGTGAAGAA
ATAAAAGCAAAAATGCATACATTAACGAAAACTATTGAAGACTCACCTGACTTAGATAGCGTATTAAAACCAACAATACT
TAGCTACCAAGATGAATTGAATCAAATAAATAATCAAATCTATCAACTAGAACAAGATAAACAAGCAGAAGCTCCACATT
ATGATGCTGATATGATTGCGAATGTACTACAAGCAATATTCAAAGATATAGACAAATTAGAGAAATCTCAGTTGAAATCA
CTATATCTAACAATCATCGATCGCATTGACATAAGAAAAGATGAGCATCATAAGAAGCAATTTTATGTTACGCTCAAGTT
AAATAATGATATAATCAAACAACTATTTAATAACCATCCACTCGACGAAGTGCTCCCTAGCACTTCGTCTTTATTTTTGC
CACAAACTTTATATATAACTATTGAATAA
ATGAAACAACTCAAAAAGAAACGTATTGGATTATATGCACGTGTATCGACTGAAATGCAAACGGATGGTTACAGTATTCA
AGGTCAATTGAATCAACTTACAGAGTATTGTCAATTTCAAGGCTATGAAGTCGTCAATGAATACACCGATCGTGGTATAT
CAGGTAAAACAATGCAACGTCCAGAATTACAACGTATGTTAAAAGATGCCAACGAAGGTAAATTAGATTGTATTATGGTC
TACAAAACAAATCGTTTAGCTAGAAATACCTCAGATTTGTTAAATATTGTCGAGGAATTGTATAAGATTAATGTCGAATT
TTTTAGTCTAACTGAAAAAATAGAAATTGCCAGTTCAACAGGTAAATTGATGCTCCAAATTTTAGCCAGCTTCGCAGAAT
TTGAACGTAATACGATTGTAGAGAATGTCTACAATGGCCAAAGACAACGTGCTATTGAAGGTTATTATCAAGGTAATTTA
CCTCTAGGCTACGATAAAGTACCTGACAGTAAAAAAGAGCTCATGATCAATCAACATGAAGCGAATATTGTTAAATATAT
TTTTGATTCATACGCTAAAGGTCATGGTTATCGTAAGATTGCGAACGCATTGAATCATAAAGGTTATGTGACTAAGAAAG
GGAAACCTTTTAGTATTTCGTCCATTACCTACATCATCTCAAACCCTTTTTACATTGGAAAGATACAGTTTGCGAAGTAT
AGACACTGGAGCGATAAAAGACGAAAAGGACTCAATGAGGAACCGATTATCGCTGATGGTAAACATGCGCCTATTATTGA
TAGAAACCTATGGGATAAAGTACAGTTTAAACGTCAAGAGAGTCGCAAGAAACCACAAGTTCACGGCAAAGGAACAAACC
TACTGACTGGGATTGTAAAATGTCCGAAATGTGGTGCAGCAATGGCGGCAAGTAATACAACTAATACATTAAAAGATGGC
ACTAAGAAAAGAATCAGATATTACTCATGTAGCAATTTTAGAAATAAAGGTTCAAAAGTTTGTTCTGCCAATAGCGTTAG
AGCAGATGTACTAGAAAAATATGTTATGGATCAGATATTGGAAATTATCAAAAGCAAAAAGGTATTGAAGCAATTGGTTG
AAAAGGTAAATGAAAAAAGTCAAATAGACGTCTCTTCTTTGAACCATGATATTGCCTATAAACAGTCACAATGTGAAGAA
ATAAAAGCAAAAATGCATACATTAACGAAAACTATTGAAGACTCACCTGACTTAGATAGCGTATTAAAACCAACAATACT
TAGCTACCAAGATGAATTGAATCAAATAAATAATCAAATCTATCAACTAGAACAAGATAAACAAGCAGAAGCTCCACATT
ATGATGCTGATATGATTGCGAATGTACTACAAGCAATATTCAAAGATATAGACAAATTAGAGAAATCTCAGTTGAAATCA
CTATATCTAACAATCATCGATCGCATTGACATAAGAAAAGATGAGCATCATAAGAAGCAATTTTATGTTACGCTCAAGTT
AAATAATGATATAATCAAACAACTATTTAATAACCATCCACTCGACGAAGTGCTCCCTAGCACTTCGTCTTTATTTTTGC
CACAAACTTTATATATAACTATTGAATAA
3D structure
| Source | ID | Structure |
|---|
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| ccrB | Staphylococcus aureus N315 |
72.694 |
100 |
0.727 |