Detailed information
Bioinformatically predicted
Overview
| Name | ccrA | Type | Machinery gene |
| Locus tag | KFV50_RS00285 | Genome accession | NZ_CP073847 |
| Coordinates | 64990..66351 (-) | Length | 453 a.a. |
| NCBI ID | WP_001631036.1 | Uniprot ID | - |
| Organism | Staphylococcus epidermidis strain B1266875 | ||
| Function | promote SCCmec transfer (predicted from homology) Homologous recombination |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| SCCmec | 63365..112026 | 64990..66351 | within | 0 |
Gene organization within MGE regions
Location: 63365..112026
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KFV50_RS00280 (KFV50_00280) | ccrB | 63365..64993 (-) | 1629 | WP_001631035.1 | recombinase family protein | Machinery gene |
| KFV50_RS00285 (KFV50_00285) | ccrA | 64990..66351 (-) | 1362 | WP_001631036.1 | recombinase family protein | Machinery gene |
| KFV50_RS00290 (KFV50_00290) | - | 66538..67167 (-) | 630 | Protein_55 | hypothetical protein | - |
| KFV50_RS00295 (KFV50_00295) | - | 67176..67514 (+) | 339 | Protein_56 | recombinase family protein | - |
| KFV50_RS00300 (KFV50_00300) | - | 67626..67985 (-) | 360 | WP_001631039.1 | hypothetical protein | - |
| KFV50_RS00305 (KFV50_00305) | - | 68192..68518 (+) | 327 | WP_000391495.1 | metalloregulator ArsR/SmtB family transcription factor | - |
| KFV50_RS00310 (KFV50_00310) | - | 68848..70773 (+) | 1926 | WP_002485723.1 | heavy metal translocating P-type ATPase | - |
| KFV50_RS00315 (KFV50_00315) | - | 72025..72330 (+) | 306 | WP_000677987.1 | hypothetical protein | - |
| KFV50_RS00320 (KFV50_00320) | - | 72528..73391 (+) | 864 | WP_000680579.1 | hypothetical protein | - |
| KFV50_RS00325 (KFV50_00325) | - | 73499..74974 (+) | 1476 | WP_001138664.1 | DUF6038 family protein | - |
| KFV50_RS00330 (KFV50_00330) | - | 75201..76301 (+) | 1101 | WP_000449985.1 | DNA polymerase | - |
| KFV50_RS00335 (KFV50_00335) | - | 76294..76665 (+) | 372 | WP_001058157.1 | hypothetical protein | - |
| KFV50_RS00340 (KFV50_00340) | - | 76662..78305 (+) | 1644 | WP_012086574.1 | DUF5906 domain-containing protein | - |
| KFV50_RS00345 (KFV50_00345) | - | 78532..80208 (+) | 1677 | WP_012086571.1 | recombinase family protein | - |
| KFV50_RS00350 (KFV50_00350) | - | 80314..80652 (+) | 339 | WP_012086569.1 | SAUGI family uracil-DNA glycosylase inhibitor | - |
| KFV50_RS00355 (KFV50_00355) | - | 80748..81059 (+) | 312 | WP_001083109.1 | DUF960 family protein | - |
| KFV50_RS00360 (KFV50_00360) | - | 81075..81581 (+) | 507 | WP_012086564.1 | DUF1643 domain-containing protein | - |
| KFV50_RS00365 (KFV50_00365) | - | 81609..82055 (+) | 447 | WP_012086562.1 | JAB domain-containing protein | - |
| KFV50_RS00370 (KFV50_00370) | - | 82225..83097 (+) | 873 | WP_012086560.1 | HTH domain-containing protein | - |
| KFV50_RS00375 (KFV50_00375) | - | 83149..83439 (+) | 291 | WP_012086558.1 | hypothetical protein | - |
| KFV50_RS00385 (KFV50_00385) | - | 83662..83817 (+) | 156 | Protein_73 | metal-sensing transcriptional repressor | - |
| KFV50_RS00390 (KFV50_00390) | - | 83814..84572 (+) | 759 | WP_000623679.1 | sulfite exporter TauE/SafE family protein | - |
| KFV50_RS00395 (KFV50_00395) | - | 84742..84951 (+) | 210 | Protein_75 | heavy metal translocating P-type ATPase | - |
| KFV50_RS00400 (KFV50_00400) | - | 84969..85514 (+) | 546 | WP_031869236.1 | YdhK family protein | - |
| KFV50_RS00405 (KFV50_00405) | - | 85957..87213 (+) | 1257 | WP_000566670.1 | DUF3578 domain-containing protein | - |
| KFV50_RS00410 (KFV50_00410) | - | 87658..88332 (-) | 675 | WP_001106057.1 | IS6-like element IS257 family transposase | - |
| KFV50_RS00415 (KFV50_00415) | - | 88416..88757 (+) | 342 | WP_001797647.1 | hydroxymethylglutaryl-CoA synthase | - |
| KFV50_RS00420 (KFV50_00420) | - | 89554..90297 (+) | 744 | WP_000958858.1 | glycerophosphoryl diester phosphodiesterase | - |
| KFV50_RS00425 (KFV50_00425) | - | 90394..90822 (+) | 429 | WP_000872606.1 | MaoC family dehydratase | - |
| KFV50_RS00430 (KFV50_00430) | mecA | 90868..92877 (-) | 2010 | WP_001801873.1 | PBP2a family beta-lactam-resistant peptidoglycan transpeptidase MecA | - |
| KFV50_RS00435 (KFV50_00435) | mecR1 | 92974..94731 (+) | 1758 | WP_000952923.1 | beta-lactam sensor/signal transducer MecR1 | - |
| KFV50_RS00440 (KFV50_00440) | mecI | 94731..95102 (+) | 372 | WP_000369214.1 | mecA-type methicillin resistance repressor MecI | - |
| KFV50_RS00445 (KFV50_00445) | psm-mec | 95187..95255 (-) | 69 | WP_014532405.1 | phenol-soluble modulin PSM-mec | - |
| KFV50_RS00450 (KFV50_00450) | - | 95610..96719 (+) | 1110 | WP_000943131.1 | ROK family transcriptional regulator | - |
| KFV50_RS00455 (KFV50_00455) | cstB | 96833..98167 (-) | 1335 | Protein_87 | persulfide dioxygenase-sulfurtransferase CstB | - |
| KFV50_RS00460 (KFV50_00460) | - | 98200..99264 (-) | 1065 | WP_000438836.1 | DsrE/DsrF/DrsH-like family protein | - |
| KFV50_RS00465 (KFV50_00465) | cstR | 99400..99660 (+) | 261 | WP_000220507.1 | persulfide-sensing transcriptional repressor CstR | - |
| KFV50_RS00470 (KFV50_00470) | - | 99660..100298 (+) | 639 | Protein_90 | sulfite exporter TauE/SafE family protein | - |
| KFV50_RS00480 (KFV50_00480) | - | 100572..101188 (-) | 617 | Protein_91 | CadD family cadmium resistance transporter | - |
| KFV50_RS00485 (KFV50_00485) | - | 101269..103683 (-) | 2415 | WP_000378485.1 | cadmium-translocating P-type ATPase CadA | - |
| KFV50_RS00490 (KFV50_00490) | - | 103676..104041 (-) | 366 | WP_000159127.1 | metalloregulator ArsR/SmtB family transcription factor | - |
| KFV50_RS00495 (KFV50_00495) | - | 104279..104656 (-) | 378 | WP_001041908.1 | DUF6262 family protein | - |
| KFV50_RS00500 (KFV50_00500) | - | 104663..106555 (-) | 1893 | WP_002485298.1 | site-specific integrase | - |
| KFV50_RS00505 (KFV50_00505) | - | 106750..107073 (-) | 324 | WP_000088091.1 | JAB domain-containing protein | - |
| KFV50_RS00510 (KFV50_00510) | - | 107066..107272 (-) | 207 | WP_001077283.1 | hypothetical protein | - |
| KFV50_RS00515 (KFV50_00515) | - | 107274..107795 (-) | 522 | WP_000836008.1 | DUF1643 domain-containing protein | - |
| KFV50_RS00520 (KFV50_00520) | - | 107814..108125 (-) | 312 | WP_000833212.1 | DUF960 family protein | - |
| KFV50_RS00525 (KFV50_00525) | - | 108210..108560 (-) | 351 | WP_000171449.1 | SAUGI family uracil-DNA glycosylase inhibitor | - |
| KFV50_RS00530 (KFV50_00530) | ccrB | 109031..110659 (-) | 1629 | WP_001186596.1 | recombinase family protein | Machinery gene |
| KFV50_RS00535 (KFV50_00535) | ccrA | 110680..112026 (-) | 1347 | WP_000816499.1 | recombinase family protein | Machinery gene |
Sequence
Protein
Download Length: 453 a.a. Molecular weight: 53316.45 Da Isoelectric Point: 9.8596
>NTDB_id=561344 KFV50_RS00285 WP_001631036.1 64990..66351(-) (ccrA) [Staphylococcus epidermidis strain B1266875]
MEEAIAYVRQSTLKQQSLATQKSLIMDTAKQYGWSNVAFYDDKKTGRHTKRSGYQKMVEIITSGKCKVLCCYRLNRLHRN
LKNAIQFFEICKKHHITIISVNDGYFDLSKEFDCFRLNILMSLAEMESNNISEQTKNGIREKAKQGKLITTHAPFGYRYR
KGCFVVQEEEAYTVKSVYRWYLQGLGYKKISQHLDSNPNLIPRKPYQVRNILLNPNYCGRVINKYGTFNDIVPPIIDIDT
FEEAQERRIHKQLNRSNSRNKLKRRIKCPYCQSTLTNLTIKKENYSLRYYVCPKNMNDAYRTCPFKSINAPELESEVLDT
CKKYFEEQSFHKRLNNTILKVLKQQQMKHKETHLTQEQLIEKLAQNRIDVKTFKRLSASCKSEENYSTYSTYQIDDKLKY
VIKNKITLQDIAPFIDCIKITQTKQLQGIYFKNSPLNIVEQSHLITPERNEVI
MEEAIAYVRQSTLKQQSLATQKSLIMDTAKQYGWSNVAFYDDKKTGRHTKRSGYQKMVEIITSGKCKVLCCYRLNRLHRN
LKNAIQFFEICKKHHITIISVNDGYFDLSKEFDCFRLNILMSLAEMESNNISEQTKNGIREKAKQGKLITTHAPFGYRYR
KGCFVVQEEEAYTVKSVYRWYLQGLGYKKISQHLDSNPNLIPRKPYQVRNILLNPNYCGRVINKYGTFNDIVPPIIDIDT
FEEAQERRIHKQLNRSNSRNKLKRRIKCPYCQSTLTNLTIKKENYSLRYYVCPKNMNDAYRTCPFKSINAPELESEVLDT
CKKYFEEQSFHKRLNNTILKVLKQQQMKHKETHLTQEQLIEKLAQNRIDVKTFKRLSASCKSEENYSTYSTYQIDDKLKY
VIKNKITLQDIAPFIDCIKITQTKQLQGIYFKNSPLNIVEQSHLITPERNEVI
Nucleotide
Download Length: 1362 bp
>NTDB_id=561344 KFV50_RS00285 WP_001631036.1 64990..66351(-) (ccrA) [Staphylococcus epidermidis strain B1266875]
ATGGAAGAAGCGATTGCTTATGTACGTCAAAGTACACTCAAACAACAAAGCTTAGCTACTCAAAAATCGCTCATTATGGA
TACCGCTAAGCAATATGGATGGTCTAATGTGGCGTTTTATGATGATAAGAAAACAGGTCGACATACAAAACGTTCAGGTT
ATCAAAAAATGGTAGAAATAATTACGTCTGGAAAATGTAAAGTATTGTGTTGCTATCGCTTGAACCGACTACATCGTAAT
TTGAAAAATGCCATACAATTCTTTGAAATTTGTAAAAAGCATCACATCACAATCATCAGTGTTAACGATGGATATTTTGA
TTTGTCTAAAGAGTTTGATTGCTTTCGTTTGAACATACTTATGAGTCTAGCGGAAATGGAATCAAACAATATCAGCGAAC
AAACAAAAAATGGGATTAGAGAAAAAGCCAAACAAGGTAAGCTAATCACAACTCATGCTCCGTTTGGCTATCGTTATAGA
AAAGGTTGTTTTGTTGTACAAGAAGAAGAAGCGTATACAGTTAAATCGGTTTATCGCTGGTACTTACAAGGTCTAGGCTA
CAAAAAGATTTCCCAACATTTGGATAGTAATCCTAACCTTATTCCTCGTAAGCCCTATCAAGTTAGAAATATTCTCTTGA
ACCCTAACTATTGCGGTCGTGTCATCAATAAATATGGCACGTTTAATGATATCGTTCCACCTATTATTGATATTGATACA
TTTGAAGAAGCACAAGAGCGTCGTATTCATAAACAACTCAATCGATCCAATTCTAGAAATAAGCTAAAGCGACGAATCAA
ATGTCCTTACTGTCAATCAACATTAACAAACTTAACGATAAAAAAAGAGAACTATTCTCTACGTTACTATGTTTGTCCTA
AAAATATGAATGACGCTTATCGTACATGCCCATTTAAAAGTATCAATGCACCAGAACTTGAAAGTGAAGTGCTCGACACT
TGTAAAAAGTATTTTGAAGAACAATCGTTTCATAAACGATTGAATAACACAATACTCAAAGTCCTAAAACAGCAACAAAT
GAAGCATAAAGAAACCCATCTAACACAAGAACAACTTATCGAAAAGCTAGCTCAAAATCGTATTGATGTAAAAACGTTCA
AACGTTTATCTGCTAGTTGTAAAAGTGAAGAGAATTACTCTACTTATTCAACCTACCAAATCGATGACAAATTAAAATAT
GTCATAAAAAATAAAATAACTTTACAGGATATAGCACCTTTTATCGATTGCATCAAAATAACTCAAACTAAACAATTACA
AGGAATCTACTTTAAAAACAGTCCACTCAATATCGTTGAACAATCACATTTAATAACTCCTGAAAGGAATGAAGTAATAT
GA
ATGGAAGAAGCGATTGCTTATGTACGTCAAAGTACACTCAAACAACAAAGCTTAGCTACTCAAAAATCGCTCATTATGGA
TACCGCTAAGCAATATGGATGGTCTAATGTGGCGTTTTATGATGATAAGAAAACAGGTCGACATACAAAACGTTCAGGTT
ATCAAAAAATGGTAGAAATAATTACGTCTGGAAAATGTAAAGTATTGTGTTGCTATCGCTTGAACCGACTACATCGTAAT
TTGAAAAATGCCATACAATTCTTTGAAATTTGTAAAAAGCATCACATCACAATCATCAGTGTTAACGATGGATATTTTGA
TTTGTCTAAAGAGTTTGATTGCTTTCGTTTGAACATACTTATGAGTCTAGCGGAAATGGAATCAAACAATATCAGCGAAC
AAACAAAAAATGGGATTAGAGAAAAAGCCAAACAAGGTAAGCTAATCACAACTCATGCTCCGTTTGGCTATCGTTATAGA
AAAGGTTGTTTTGTTGTACAAGAAGAAGAAGCGTATACAGTTAAATCGGTTTATCGCTGGTACTTACAAGGTCTAGGCTA
CAAAAAGATTTCCCAACATTTGGATAGTAATCCTAACCTTATTCCTCGTAAGCCCTATCAAGTTAGAAATATTCTCTTGA
ACCCTAACTATTGCGGTCGTGTCATCAATAAATATGGCACGTTTAATGATATCGTTCCACCTATTATTGATATTGATACA
TTTGAAGAAGCACAAGAGCGTCGTATTCATAAACAACTCAATCGATCCAATTCTAGAAATAAGCTAAAGCGACGAATCAA
ATGTCCTTACTGTCAATCAACATTAACAAACTTAACGATAAAAAAAGAGAACTATTCTCTACGTTACTATGTTTGTCCTA
AAAATATGAATGACGCTTATCGTACATGCCCATTTAAAAGTATCAATGCACCAGAACTTGAAAGTGAAGTGCTCGACACT
TGTAAAAAGTATTTTGAAGAACAATCGTTTCATAAACGATTGAATAACACAATACTCAAAGTCCTAAAACAGCAACAAAT
GAAGCATAAAGAAACCCATCTAACACAAGAACAACTTATCGAAAAGCTAGCTCAAAATCGTATTGATGTAAAAACGTTCA
AACGTTTATCTGCTAGTTGTAAAAGTGAAGAGAATTACTCTACTTATTCAACCTACCAAATCGATGACAAATTAAAATAT
GTCATAAAAAATAAAATAACTTTACAGGATATAGCACCTTTTATCGATTGCATCAAAATAACTCAAACTAAACAATTACA
AGGAATCTACTTTAAAAACAGTCCACTCAATATCGTTGAACAATCACATTTAATAACTCCTGAAAGGAATGAAGTAATAT
GA
3D structure
| Source | ID | Structure |
|---|
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| ccrA | Staphylococcus aureus COL |
54.628 |
97.792 |
0.534 |
| ccrA | Staphylococcus aureus N315 |
50.564 |
97.792 |
0.494 |