Detailed information
Bioinformatically predicted
Overview
| Name | ccrB | Type | Machinery gene |
| Locus tag | KFV41_RS12685 | Genome accession | NZ_CP073844 |
| Coordinates | 2603760..2605388 (+) | Length | 542 a.a. |
| NCBI ID | WP_001186596.1 | Uniprot ID | - |
| Organism | Staphylococcus epidermidis strain B1265603 | ||
| Function | promote SCCmec transfer (predicted from homology) Homologous recombination |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| SCCmec | 2602393..2651054 | 2603760..2605388 | within | 0 |
Gene organization within MGE regions
Location: 2602393..2651054
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KFV41_RS12680 (KFV41_12690) | ccrA | 2602393..2603739 (+) | 1347 | WP_000816499.1 | recombinase family protein | Machinery gene |
| KFV41_RS12685 (KFV41_12695) | ccrB | 2603760..2605388 (+) | 1629 | WP_001186596.1 | recombinase family protein | Machinery gene |
| KFV41_RS12690 (KFV41_12700) | - | 2605859..2606209 (+) | 351 | WP_000171449.1 | SAUGI family uracil-DNA glycosylase inhibitor | - |
| KFV41_RS12695 (KFV41_12705) | - | 2606294..2606605 (+) | 312 | WP_000833212.1 | DUF960 family protein | - |
| KFV41_RS12700 (KFV41_12710) | - | 2606624..2607145 (+) | 522 | WP_000836008.1 | DUF1643 domain-containing protein | - |
| KFV41_RS12705 (KFV41_12715) | - | 2607147..2607353 (+) | 207 | WP_001077283.1 | hypothetical protein | - |
| KFV41_RS12710 (KFV41_12720) | - | 2607346..2607669 (+) | 324 | WP_000088091.1 | JAB domain-containing protein | - |
| KFV41_RS12715 (KFV41_12725) | - | 2607864..2609756 (+) | 1893 | WP_002485298.1 | site-specific integrase | - |
| KFV41_RS12720 (KFV41_12730) | - | 2609763..2610140 (+) | 378 | WP_001041908.1 | DUF6262 family protein | - |
| KFV41_RS12725 (KFV41_12735) | - | 2610378..2610743 (+) | 366 | WP_000159127.1 | metalloregulator ArsR/SmtB family transcription factor | - |
| KFV41_RS12730 (KFV41_12740) | - | 2610736..2613150 (+) | 2415 | WP_000378485.1 | cadmium-translocating P-type ATPase CadA | - |
| KFV41_RS12735 (KFV41_12745) | - | 2613231..2613847 (+) | 617 | Protein_2491 | CadD family cadmium resistance transporter | - |
| KFV41_RS12745 (KFV41_12755) | - | 2614121..2614759 (-) | 639 | Protein_2492 | sulfite exporter TauE/SafE family protein | - |
| KFV41_RS12750 (KFV41_12760) | cstR | 2614759..2615019 (-) | 261 | WP_000220507.1 | persulfide-sensing transcriptional repressor CstR | - |
| KFV41_RS12755 (KFV41_12765) | - | 2615155..2616219 (+) | 1065 | WP_000438836.1 | DsrE/DsrF/DrsH-like family protein | - |
| KFV41_RS12760 (KFV41_12770) | cstB | 2616252..2617586 (+) | 1335 | Protein_2495 | persulfide dioxygenase-sulfurtransferase CstB | - |
| KFV41_RS12765 (KFV41_12775) | - | 2617700..2618809 (-) | 1110 | WP_000943131.1 | ROK family transcriptional regulator | - |
| KFV41_RS12770 (KFV41_12780) | psm-mec | 2619164..2619232 (+) | 69 | WP_014532405.1 | phenol-soluble modulin PSM-mec | - |
| KFV41_RS12775 (KFV41_12785) | mecI | 2619317..2619688 (-) | 372 | WP_000369214.1 | mecA-type methicillin resistance repressor MecI | - |
| KFV41_RS12780 (KFV41_12790) | mecR1 | 2619688..2621445 (-) | 1758 | WP_000952923.1 | beta-lactam sensor/signal transducer MecR1 | - |
| KFV41_RS12785 (KFV41_12795) | mecA | 2621542..2623551 (+) | 2010 | WP_001801873.1 | PBP2a family beta-lactam-resistant peptidoglycan transpeptidase MecA | - |
| KFV41_RS12790 (KFV41_12800) | - | 2623597..2624025 (-) | 429 | WP_000872606.1 | MaoC family dehydratase | - |
| KFV41_RS12795 (KFV41_12805) | - | 2624122..2624865 (-) | 744 | WP_000958858.1 | glycerophosphoryl diester phosphodiesterase | - |
| KFV41_RS12800 (KFV41_12810) | - | 2625662..2626051 (-) | 390 | WP_020444595.1 | hydroxymethylglutaryl-CoA synthase | - |
| KFV41_RS12805 (KFV41_12815) | - | 2626087..2626761 (+) | 675 | WP_001106057.1 | IS6-like element IS257 family transposase | - |
| KFV41_RS12810 (KFV41_12820) | - | 2627206..2628462 (-) | 1257 | WP_000566670.1 | DUF3578 domain-containing protein | - |
| KFV41_RS12815 (KFV41_12825) | - | 2628905..2629450 (-) | 546 | WP_031869236.1 | YdhK family protein | - |
| KFV41_RS12820 (KFV41_12830) | - | 2629468..2629677 (-) | 210 | Protein_2507 | heavy metal translocating P-type ATPase | - |
| KFV41_RS12825 (KFV41_12835) | - | 2629847..2630605 (-) | 759 | WP_000623679.1 | sulfite exporter TauE/SafE family protein | - |
| KFV41_RS12830 (KFV41_12840) | - | 2630602..2630757 (-) | 156 | Protein_2509 | metal-sensing transcriptional repressor | - |
| KFV41_RS12840 (KFV41_12850) | - | 2630980..2631270 (-) | 291 | WP_012086558.1 | hypothetical protein | - |
| KFV41_RS12845 (KFV41_12855) | - | 2631322..2632194 (-) | 873 | WP_012086560.1 | HTH domain-containing protein | - |
| KFV41_RS12850 (KFV41_12860) | - | 2632364..2632810 (-) | 447 | WP_012086562.1 | JAB domain-containing protein | - |
| KFV41_RS12855 (KFV41_12865) | - | 2632838..2633344 (-) | 507 | WP_012086564.1 | DUF1643 domain-containing protein | - |
| KFV41_RS12860 (KFV41_12870) | - | 2633360..2633671 (-) | 312 | WP_001083109.1 | DUF960 family protein | - |
| KFV41_RS12865 (KFV41_12875) | - | 2633767..2634105 (-) | 339 | WP_012086569.1 | SAUGI family uracil-DNA glycosylase inhibitor | - |
| KFV41_RS12870 (KFV41_12880) | - | 2634211..2635887 (-) | 1677 | WP_012086571.1 | recombinase family protein | - |
| KFV41_RS12875 (KFV41_12885) | - | 2636114..2637757 (-) | 1644 | WP_012086574.1 | DUF5906 domain-containing protein | - |
| KFV41_RS12880 (KFV41_12890) | - | 2637754..2638125 (-) | 372 | WP_001058157.1 | hypothetical protein | - |
| KFV41_RS12885 (KFV41_12895) | - | 2638118..2639218 (-) | 1101 | WP_000449985.1 | DNA polymerase | - |
| KFV41_RS12890 (KFV41_12900) | - | 2639445..2640920 (-) | 1476 | WP_001138664.1 | DUF6038 family protein | - |
| KFV41_RS12895 (KFV41_12905) | - | 2641028..2641891 (-) | 864 | WP_000680579.1 | hypothetical protein | - |
| KFV41_RS12900 (KFV41_12910) | - | 2642089..2642394 (-) | 306 | WP_000677987.1 | hypothetical protein | - |
| KFV41_RS12905 (KFV41_12915) | - | 2643646..2645571 (-) | 1926 | WP_002485723.1 | heavy metal translocating P-type ATPase | - |
| KFV41_RS12910 (KFV41_12920) | - | 2645901..2646227 (-) | 327 | WP_000391495.1 | metalloregulator ArsR/SmtB family transcription factor | - |
| KFV41_RS12915 (KFV41_12925) | - | 2646434..2646793 (+) | 360 | WP_001631039.1 | hypothetical protein | - |
| KFV41_RS12920 (KFV41_12930) | - | 2646905..2647243 (-) | 339 | Protein_2526 | recombinase family protein | - |
| KFV41_RS12925 (KFV41_12935) | - | 2647252..2647881 (+) | 630 | Protein_2527 | hypothetical protein | - |
| KFV41_RS12930 (KFV41_12940) | ccrA | 2648068..2649429 (+) | 1362 | WP_001631036.1 | recombinase family protein | Machinery gene |
| KFV41_RS12935 (KFV41_12945) | ccrB | 2649426..2651054 (+) | 1629 | WP_001631035.1 | recombinase family protein | Machinery gene |
Sequence
Protein
Download Length: 542 a.a. Molecular weight: 62274.15 Da Isoelectric Point: 9.7334
>NTDB_id=561336 KFV41_RS12685 WP_001186596.1 2603760..2605388(+) (ccrB) [Staphylococcus epidermidis strain B1265603]
MQQLKQKRVGIYVRVSTEIQSTEGYSIDGQINQIREYCDFNNFVVVDVYADRGISGKSMNRPELQRLLKDANEGQIDSVM
VYKTNRLARNTSDLLKIVEDLHRQNVEFFSLSERMEVNTSSGKLMLQILASFSEFERNNIVENVFMGQTRRAQEGYYQGN
LPLGYDKIPDSKHELMINQHEANIVKYIFESYAKGHGYRKIANALNHKGYVTKKGKPFSIGSVTYILSNPFYVGKIQFAK
YKDWNEKRRKGLNDKPIIAEGKHSPIIIQDLWDKVQLRKKQVSQKPQVHGKGTNLLTGIVHCPQCGAPMAASNTTNTLKD
GTKKRIRYYSCSNFRNKGSKVCSANSVRADVIEKYVMDQILEIVKSDKVINQVLERVNQENKVDIGALNHDIAYKQQQYD
EVSGKLHNLVKTIEDNPDLTSALKATIHQYETQLNDITNQMNQLKQQQNQEKLSYDTKQIAALLQRIFQNIESMDKAQLK
ALYLTVIDRIDIRKDGNHKKQFYVTLKLNNEIIKQLFNNTPLDEVLLSTSSLFLPQTLFLQI
MQQLKQKRVGIYVRVSTEIQSTEGYSIDGQINQIREYCDFNNFVVVDVYADRGISGKSMNRPELQRLLKDANEGQIDSVM
VYKTNRLARNTSDLLKIVEDLHRQNVEFFSLSERMEVNTSSGKLMLQILASFSEFERNNIVENVFMGQTRRAQEGYYQGN
LPLGYDKIPDSKHELMINQHEANIVKYIFESYAKGHGYRKIANALNHKGYVTKKGKPFSIGSVTYILSNPFYVGKIQFAK
YKDWNEKRRKGLNDKPIIAEGKHSPIIIQDLWDKVQLRKKQVSQKPQVHGKGTNLLTGIVHCPQCGAPMAASNTTNTLKD
GTKKRIRYYSCSNFRNKGSKVCSANSVRADVIEKYVMDQILEIVKSDKVINQVLERVNQENKVDIGALNHDIAYKQQQYD
EVSGKLHNLVKTIEDNPDLTSALKATIHQYETQLNDITNQMNQLKQQQNQEKLSYDTKQIAALLQRIFQNIESMDKAQLK
ALYLTVIDRIDIRKDGNHKKQFYVTLKLNNEIIKQLFNNTPLDEVLLSTSSLFLPQTLFLQI
Nucleotide
Download Length: 1629 bp
>NTDB_id=561336 KFV41_RS12685 WP_001186596.1 2603760..2605388(+) (ccrB) [Staphylococcus epidermidis strain B1265603]
ATGCAACAACTCAAACAAAAACGTGTCGGTATCTATGTTCGTGTATCAACGGAAATCCAAAGTACTGAAGGCTATAGTAT
CGATGGACAAATCAATCAAATTCGAGAATATTGTGATTTCAATAACTTTGTTGTTGTAGATGTATACGCGGATAGAGGTA
TCTCTGGAAAATCTATGAACCGACCAGAACTACAACGTTTGTTAAAAGATGCGAACGAAGGTCAGATTGATTCTGTTATG
GTCTACAAAACAAACCGACTAGCACGTAACACTTCTGACTTACTCAAAATTGTTGAAGACCTTCATCGTCAAAATGTCGA
ATTCTTCAGCTTATCTGAGCGTATGGAAGTCAATACAAGCAGTGGTAAATTGATGCTACAAATTCTAGCGAGTTTTTCAG
AATTTGAAAGAAATAATATTGTCGAAAATGTATTCATGGGTCAAACCCGACGCGCTCAAGAAGGCTATTATCAAGGCAAT
TTGCCGCTGGGCTATGACAAAATACCGGATAGCAAGCATGAACTCATGATAAACCAACATGAAGCGAATATTGTCAAATA
TATATTTGAGTCATATGCTAAAGGCCACGGATATCGTAAAATTGCGAATGCACTCAATCACAAAGGATACGTGACTAAAA
AAGGAAAGCCTTTCAGTATTGGTTCAGTGACCTATATCTTATCTAATCCATTCTATGTTGGTAAAATTCAATTCGCAAAG
TACAAAGATTGGAATGAAAAGCGTCGTAAAGGGCTGAATGATAAACCAATAATAGCTGAAGGTAAGCATTCCCCTATTAT
TATTCAAGACTTATGGGATAAAGTCCAATTACGTAAAAAACAAGTCAGTCAAAAACCTCAAGTCCACGGTAAAGGAACTA
ATCTATTAACAGGTATCGTTCATTGTCCACAATGTGGTGCACCAATGGCAGCTAGTAACACAACGAACACATTGAAAGAT
GGTACCAAGAAGCGAATACGTTATTATTCTTGCAGTAACTTCCGAAACAAAGGCTCAAAAGTATGTTCTGCGAATAGCGT
TAGAGCTGATGTGATTGAGAAATACGTCATGGATCAAATACTCGAAATTGTCAAAAGTGATAAAGTCATTAACCAAGTCT
TAGAACGTGTCAATCAAGAAAATAAAGTCGATATTGGTGCATTGAACCACGATATCGCTTATAAACAACAACAATACGAT
GAAGTCAGCGGGAAACTCCATAATTTAGTTAAAACCATTGAAGATAATCCGGACCTAACATCTGCATTGAAAGCAACTAT
TCATCAATATGAAACACAACTCAATGACATTACAAATCAAATGAATCAACTCAAACAGCAACAAAATCAAGAGAAACTAT
CTTATGATACGAAACAAATCGCTGCCCTATTACAACGAATATTTCAAAATATAGAATCAATGGATAAAGCACAACTCAAA
GCATTATATCTTACAGTCATTGACCGTATTGATATTCGTAAAGACGGTAATCATAAAAAACAGTTCTACGTTACACTAAA
ACTCAATAATGAAATTATTAAACAACTTTTCAATAATACCCCTCTCGACGAAGTGCTCCTCAGCACTTCGTCTTTATTTT
TGCCTCAAACGCTCTTTCTTCAAATCTAA
ATGCAACAACTCAAACAAAAACGTGTCGGTATCTATGTTCGTGTATCAACGGAAATCCAAAGTACTGAAGGCTATAGTAT
CGATGGACAAATCAATCAAATTCGAGAATATTGTGATTTCAATAACTTTGTTGTTGTAGATGTATACGCGGATAGAGGTA
TCTCTGGAAAATCTATGAACCGACCAGAACTACAACGTTTGTTAAAAGATGCGAACGAAGGTCAGATTGATTCTGTTATG
GTCTACAAAACAAACCGACTAGCACGTAACACTTCTGACTTACTCAAAATTGTTGAAGACCTTCATCGTCAAAATGTCGA
ATTCTTCAGCTTATCTGAGCGTATGGAAGTCAATACAAGCAGTGGTAAATTGATGCTACAAATTCTAGCGAGTTTTTCAG
AATTTGAAAGAAATAATATTGTCGAAAATGTATTCATGGGTCAAACCCGACGCGCTCAAGAAGGCTATTATCAAGGCAAT
TTGCCGCTGGGCTATGACAAAATACCGGATAGCAAGCATGAACTCATGATAAACCAACATGAAGCGAATATTGTCAAATA
TATATTTGAGTCATATGCTAAAGGCCACGGATATCGTAAAATTGCGAATGCACTCAATCACAAAGGATACGTGACTAAAA
AAGGAAAGCCTTTCAGTATTGGTTCAGTGACCTATATCTTATCTAATCCATTCTATGTTGGTAAAATTCAATTCGCAAAG
TACAAAGATTGGAATGAAAAGCGTCGTAAAGGGCTGAATGATAAACCAATAATAGCTGAAGGTAAGCATTCCCCTATTAT
TATTCAAGACTTATGGGATAAAGTCCAATTACGTAAAAAACAAGTCAGTCAAAAACCTCAAGTCCACGGTAAAGGAACTA
ATCTATTAACAGGTATCGTTCATTGTCCACAATGTGGTGCACCAATGGCAGCTAGTAACACAACGAACACATTGAAAGAT
GGTACCAAGAAGCGAATACGTTATTATTCTTGCAGTAACTTCCGAAACAAAGGCTCAAAAGTATGTTCTGCGAATAGCGT
TAGAGCTGATGTGATTGAGAAATACGTCATGGATCAAATACTCGAAATTGTCAAAAGTGATAAAGTCATTAACCAAGTCT
TAGAACGTGTCAATCAAGAAAATAAAGTCGATATTGGTGCATTGAACCACGATATCGCTTATAAACAACAACAATACGAT
GAAGTCAGCGGGAAACTCCATAATTTAGTTAAAACCATTGAAGATAATCCGGACCTAACATCTGCATTGAAAGCAACTAT
TCATCAATATGAAACACAACTCAATGACATTACAAATCAAATGAATCAACTCAAACAGCAACAAAATCAAGAGAAACTAT
CTTATGATACGAAACAAATCGCTGCCCTATTACAACGAATATTTCAAAATATAGAATCAATGGATAAAGCACAACTCAAA
GCATTATATCTTACAGTCATTGACCGTATTGATATTCGTAAAGACGGTAATCATAAAAAACAGTTCTACGTTACACTAAA
ACTCAATAATGAAATTATTAAACAACTTTTCAATAATACCCCTCTCGACGAAGTGCTCCTCAGCACTTCGTCTTTATTTT
TGCCTCAAACGCTCTTTCTTCAAATCTAA
3D structure
| Source | ID | Structure |
|---|
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| ccrB | Staphylococcus aureus N315 |
86.531 |
100 |
0.865 |