Detailed information
Bioinformatically predicted
Overview
| Name | ccrA | Type | Machinery gene |
| Locus tag | KFV39_RS12975 | Genome accession | NZ_CP073840 |
| Coordinates | 2647031..2648392 (+) | Length | 453 a.a. |
| NCBI ID | WP_001631036.1 | Uniprot ID | - |
| Organism | Staphylococcus epidermidis strain B1264454 | ||
| Function | promote SCCmec transfer (predicted from homology) Homologous recombination |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| SCCmec | 2601356..2650017 | 2647031..2648392 | within | 0 |
Gene organization within MGE regions
Location: 2601356..2650017
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KFV39_RS12725 (KFV39_12735) | ccrA | 2601356..2602702 (+) | 1347 | WP_000816499.1 | recombinase family protein | Machinery gene |
| KFV39_RS12730 (KFV39_12740) | ccrB | 2602723..2604351 (+) | 1629 | WP_001186596.1 | recombinase family protein | Machinery gene |
| KFV39_RS12735 (KFV39_12745) | - | 2604822..2605172 (+) | 351 | WP_000171449.1 | SAUGI family uracil-DNA glycosylase inhibitor | - |
| KFV39_RS12740 (KFV39_12750) | - | 2605257..2605568 (+) | 312 | WP_000833212.1 | DUF960 family protein | - |
| KFV39_RS12745 (KFV39_12755) | - | 2605587..2606108 (+) | 522 | WP_000836008.1 | DUF1643 domain-containing protein | - |
| KFV39_RS12750 (KFV39_12760) | - | 2606110..2606316 (+) | 207 | WP_001077283.1 | hypothetical protein | - |
| KFV39_RS12755 (KFV39_12765) | - | 2606309..2606632 (+) | 324 | WP_000088091.1 | JAB domain-containing protein | - |
| KFV39_RS12760 (KFV39_12770) | - | 2606827..2608719 (+) | 1893 | WP_002485298.1 | site-specific integrase | - |
| KFV39_RS12765 (KFV39_12775) | - | 2608726..2609103 (+) | 378 | WP_001041908.1 | DUF6262 family protein | - |
| KFV39_RS12770 (KFV39_12780) | - | 2609341..2609706 (+) | 366 | WP_000159127.1 | metalloregulator ArsR/SmtB family transcription factor | - |
| KFV39_RS12775 (KFV39_12785) | - | 2609699..2612113 (+) | 2415 | WP_000378485.1 | cadmium-translocating P-type ATPase CadA | - |
| KFV39_RS12780 (KFV39_12790) | - | 2612194..2612810 (+) | 617 | Protein_2483 | CadD family cadmium resistance transporter | - |
| KFV39_RS12790 (KFV39_12800) | - | 2613084..2613722 (-) | 639 | Protein_2484 | sulfite exporter TauE/SafE family protein | - |
| KFV39_RS12795 (KFV39_12805) | cstR | 2613722..2613982 (-) | 261 | WP_000220507.1 | persulfide-sensing transcriptional repressor CstR | - |
| KFV39_RS12800 (KFV39_12810) | - | 2614118..2615182 (+) | 1065 | WP_000438836.1 | DsrE/DsrF/DrsH-like family protein | - |
| KFV39_RS12805 (KFV39_12815) | cstB | 2615215..2616549 (+) | 1335 | Protein_2487 | persulfide dioxygenase-sulfurtransferase CstB | - |
| KFV39_RS12810 (KFV39_12820) | - | 2616663..2617793 (-) | 1131 | WP_010922808.1 | ROK family transcriptional regulator | - |
| KFV39_RS12815 (KFV39_12825) | psm-mec | 2618127..2618195 (+) | 69 | WP_014532405.1 | phenol-soluble modulin PSM-mec | - |
| KFV39_RS12820 (KFV39_12830) | mecI | 2618280..2618651 (-) | 372 | WP_000369214.1 | mecA-type methicillin resistance repressor MecI | - |
| KFV39_RS12825 (KFV39_12835) | mecR1 | 2618651..2620408 (-) | 1758 | WP_000952923.1 | beta-lactam sensor/signal transducer MecR1 | - |
| KFV39_RS12830 (KFV39_12840) | mecA | 2620505..2622514 (+) | 2010 | WP_001801873.1 | PBP2a family beta-lactam-resistant peptidoglycan transpeptidase MecA | - |
| KFV39_RS12835 (KFV39_12845) | - | 2622560..2622988 (-) | 429 | WP_000872606.1 | MaoC family dehydratase | - |
| KFV39_RS12840 (KFV39_12850) | - | 2623085..2623828 (-) | 744 | WP_000958858.1 | glycerophosphoryl diester phosphodiesterase | - |
| KFV39_RS12845 (KFV39_12855) | - | 2624625..2625014 (-) | 390 | WP_020444595.1 | hydroxymethylglutaryl-CoA synthase | - |
| KFV39_RS12850 (KFV39_12860) | - | 2625050..2625724 (+) | 675 | WP_001106057.1 | IS6-like element IS257 family transposase | - |
| KFV39_RS12855 (KFV39_12865) | - | 2626169..2627425 (-) | 1257 | WP_000566670.1 | DUF3578 domain-containing protein | - |
| KFV39_RS12860 (KFV39_12870) | - | 2627868..2628413 (-) | 546 | WP_031869236.1 | YdhK family protein | - |
| KFV39_RS12865 (KFV39_12875) | - | 2628431..2628640 (-) | 210 | Protein_2499 | heavy metal translocating P-type ATPase | - |
| KFV39_RS12870 (KFV39_12880) | - | 2628810..2629568 (-) | 759 | WP_000623679.1 | sulfite exporter TauE/SafE family protein | - |
| KFV39_RS12875 (KFV39_12885) | - | 2629565..2629720 (-) | 156 | Protein_2501 | metal-sensing transcriptional repressor | - |
| KFV39_RS12885 (KFV39_12895) | - | 2629943..2630233 (-) | 291 | WP_012086558.1 | hypothetical protein | - |
| KFV39_RS12890 (KFV39_12900) | - | 2630285..2631157 (-) | 873 | WP_012086560.1 | HTH domain-containing protein | - |
| KFV39_RS12895 (KFV39_12905) | - | 2631327..2631773 (-) | 447 | WP_012086562.1 | JAB domain-containing protein | - |
| KFV39_RS12900 (KFV39_12910) | - | 2631801..2632307 (-) | 507 | WP_012086564.1 | DUF1643 domain-containing protein | - |
| KFV39_RS12905 (KFV39_12915) | - | 2632323..2632634 (-) | 312 | WP_001083109.1 | DUF960 family protein | - |
| KFV39_RS12910 (KFV39_12920) | - | 2632730..2633068 (-) | 339 | WP_012086569.1 | SAUGI family uracil-DNA glycosylase inhibitor | - |
| KFV39_RS12915 (KFV39_12925) | - | 2633174..2634850 (-) | 1677 | WP_012086571.1 | recombinase family protein | - |
| KFV39_RS12920 (KFV39_12930) | - | 2635077..2636720 (-) | 1644 | WP_012086574.1 | DUF5906 domain-containing protein | - |
| KFV39_RS12925 (KFV39_12935) | - | 2636717..2637088 (-) | 372 | WP_001058157.1 | hypothetical protein | - |
| KFV39_RS12930 (KFV39_12940) | - | 2637081..2638181 (-) | 1101 | WP_000449985.1 | DNA polymerase | - |
| KFV39_RS12935 (KFV39_12945) | - | 2638408..2639883 (-) | 1476 | WP_001138664.1 | DUF6038 family protein | - |
| KFV39_RS12940 (KFV39_12950) | - | 2639991..2640854 (-) | 864 | WP_000680579.1 | hypothetical protein | - |
| KFV39_RS12945 (KFV39_12955) | - | 2641052..2641357 (-) | 306 | WP_000677987.1 | hypothetical protein | - |
| KFV39_RS12950 (KFV39_12960) | - | 2642609..2644534 (-) | 1926 | WP_002485723.1 | heavy metal translocating P-type ATPase | - |
| KFV39_RS12955 (KFV39_12965) | - | 2644864..2645190 (-) | 327 | WP_000391495.1 | metalloregulator ArsR/SmtB family transcription factor | - |
| KFV39_RS12960 (KFV39_12970) | - | 2645397..2645756 (+) | 360 | WP_001631039.1 | hypothetical protein | - |
| KFV39_RS12965 (KFV39_12975) | - | 2645868..2646206 (-) | 339 | Protein_2518 | recombinase family protein | - |
| KFV39_RS12970 (KFV39_12980) | - | 2646215..2646844 (+) | 630 | Protein_2519 | hypothetical protein | - |
| KFV39_RS12975 (KFV39_12985) | ccrA | 2647031..2648392 (+) | 1362 | WP_001631036.1 | recombinase family protein | Machinery gene |
| KFV39_RS12980 (KFV39_12990) | ccrB | 2648389..2650017 (+) | 1629 | WP_001631035.1 | recombinase family protein | Machinery gene |
Sequence
Protein
Download Length: 453 a.a. Molecular weight: 53316.45 Da Isoelectric Point: 9.8596
>NTDB_id=561262 KFV39_RS12975 WP_001631036.1 2647031..2648392(+) (ccrA) [Staphylococcus epidermidis strain B1264454]
MEEAIAYVRQSTLKQQSLATQKSLIMDTAKQYGWSNVAFYDDKKTGRHTKRSGYQKMVEIITSGKCKVLCCYRLNRLHRN
LKNAIQFFEICKKHHITIISVNDGYFDLSKEFDCFRLNILMSLAEMESNNISEQTKNGIREKAKQGKLITTHAPFGYRYR
KGCFVVQEEEAYTVKSVYRWYLQGLGYKKISQHLDSNPNLIPRKPYQVRNILLNPNYCGRVINKYGTFNDIVPPIIDIDT
FEEAQERRIHKQLNRSNSRNKLKRRIKCPYCQSTLTNLTIKKENYSLRYYVCPKNMNDAYRTCPFKSINAPELESEVLDT
CKKYFEEQSFHKRLNNTILKVLKQQQMKHKETHLTQEQLIEKLAQNRIDVKTFKRLSASCKSEENYSTYSTYQIDDKLKY
VIKNKITLQDIAPFIDCIKITQTKQLQGIYFKNSPLNIVEQSHLITPERNEVI
MEEAIAYVRQSTLKQQSLATQKSLIMDTAKQYGWSNVAFYDDKKTGRHTKRSGYQKMVEIITSGKCKVLCCYRLNRLHRN
LKNAIQFFEICKKHHITIISVNDGYFDLSKEFDCFRLNILMSLAEMESNNISEQTKNGIREKAKQGKLITTHAPFGYRYR
KGCFVVQEEEAYTVKSVYRWYLQGLGYKKISQHLDSNPNLIPRKPYQVRNILLNPNYCGRVINKYGTFNDIVPPIIDIDT
FEEAQERRIHKQLNRSNSRNKLKRRIKCPYCQSTLTNLTIKKENYSLRYYVCPKNMNDAYRTCPFKSINAPELESEVLDT
CKKYFEEQSFHKRLNNTILKVLKQQQMKHKETHLTQEQLIEKLAQNRIDVKTFKRLSASCKSEENYSTYSTYQIDDKLKY
VIKNKITLQDIAPFIDCIKITQTKQLQGIYFKNSPLNIVEQSHLITPERNEVI
Nucleotide
Download Length: 1362 bp
>NTDB_id=561262 KFV39_RS12975 WP_001631036.1 2647031..2648392(+) (ccrA) [Staphylococcus epidermidis strain B1264454]
ATGGAAGAAGCGATTGCTTATGTACGTCAAAGTACACTCAAACAACAAAGCTTAGCTACTCAAAAATCGCTCATTATGGA
TACCGCTAAGCAATATGGATGGTCTAATGTGGCGTTTTATGATGATAAGAAAACAGGTCGACATACAAAACGTTCAGGTT
ATCAAAAAATGGTAGAAATAATTACGTCTGGAAAATGTAAAGTATTGTGTTGCTATCGCTTGAACCGACTACATCGTAAT
TTGAAAAATGCCATACAATTCTTTGAAATTTGTAAAAAGCATCACATCACAATCATCAGTGTTAACGATGGATATTTTGA
TTTGTCTAAAGAGTTTGATTGCTTTCGTTTGAACATACTTATGAGTCTAGCGGAAATGGAATCAAACAATATCAGCGAAC
AAACAAAAAATGGGATTAGAGAAAAAGCCAAACAAGGTAAGCTAATCACAACTCATGCTCCGTTTGGCTATCGTTATAGA
AAAGGTTGTTTTGTTGTACAAGAAGAAGAAGCGTATACAGTTAAATCGGTTTATCGCTGGTACTTACAAGGTCTAGGCTA
CAAAAAGATTTCCCAACATTTGGATAGTAATCCTAACCTTATTCCTCGTAAGCCCTATCAAGTTAGAAATATTCTCTTGA
ACCCTAACTATTGCGGTCGTGTCATCAATAAATATGGCACGTTTAATGATATCGTTCCACCTATTATTGATATTGATACA
TTTGAAGAAGCACAAGAGCGTCGTATTCATAAACAACTCAATCGATCCAATTCTAGAAATAAGCTAAAGCGACGAATCAA
ATGTCCTTACTGTCAATCAACATTAACAAACTTAACGATAAAAAAAGAGAACTATTCTCTACGTTACTATGTTTGTCCTA
AAAATATGAATGACGCTTATCGTACATGCCCATTTAAAAGTATCAATGCACCAGAACTTGAAAGTGAAGTGCTCGACACT
TGTAAAAAGTATTTTGAAGAACAATCGTTTCATAAACGATTGAATAACACAATACTCAAAGTCCTAAAACAGCAACAAAT
GAAGCATAAAGAAACCCATCTAACACAAGAACAACTTATCGAAAAGCTAGCTCAAAATCGTATTGATGTAAAAACGTTCA
AACGTTTATCTGCTAGTTGTAAAAGTGAAGAGAATTACTCTACTTATTCAACCTACCAAATCGATGACAAATTAAAATAT
GTCATAAAAAATAAAATAACTTTACAGGATATAGCACCTTTTATCGATTGCATCAAAATAACTCAAACTAAACAATTACA
AGGAATCTACTTTAAAAACAGTCCACTCAATATCGTTGAACAATCACATTTAATAACTCCTGAAAGGAATGAAGTAATAT
GA
ATGGAAGAAGCGATTGCTTATGTACGTCAAAGTACACTCAAACAACAAAGCTTAGCTACTCAAAAATCGCTCATTATGGA
TACCGCTAAGCAATATGGATGGTCTAATGTGGCGTTTTATGATGATAAGAAAACAGGTCGACATACAAAACGTTCAGGTT
ATCAAAAAATGGTAGAAATAATTACGTCTGGAAAATGTAAAGTATTGTGTTGCTATCGCTTGAACCGACTACATCGTAAT
TTGAAAAATGCCATACAATTCTTTGAAATTTGTAAAAAGCATCACATCACAATCATCAGTGTTAACGATGGATATTTTGA
TTTGTCTAAAGAGTTTGATTGCTTTCGTTTGAACATACTTATGAGTCTAGCGGAAATGGAATCAAACAATATCAGCGAAC
AAACAAAAAATGGGATTAGAGAAAAAGCCAAACAAGGTAAGCTAATCACAACTCATGCTCCGTTTGGCTATCGTTATAGA
AAAGGTTGTTTTGTTGTACAAGAAGAAGAAGCGTATACAGTTAAATCGGTTTATCGCTGGTACTTACAAGGTCTAGGCTA
CAAAAAGATTTCCCAACATTTGGATAGTAATCCTAACCTTATTCCTCGTAAGCCCTATCAAGTTAGAAATATTCTCTTGA
ACCCTAACTATTGCGGTCGTGTCATCAATAAATATGGCACGTTTAATGATATCGTTCCACCTATTATTGATATTGATACA
TTTGAAGAAGCACAAGAGCGTCGTATTCATAAACAACTCAATCGATCCAATTCTAGAAATAAGCTAAAGCGACGAATCAA
ATGTCCTTACTGTCAATCAACATTAACAAACTTAACGATAAAAAAAGAGAACTATTCTCTACGTTACTATGTTTGTCCTA
AAAATATGAATGACGCTTATCGTACATGCCCATTTAAAAGTATCAATGCACCAGAACTTGAAAGTGAAGTGCTCGACACT
TGTAAAAAGTATTTTGAAGAACAATCGTTTCATAAACGATTGAATAACACAATACTCAAAGTCCTAAAACAGCAACAAAT
GAAGCATAAAGAAACCCATCTAACACAAGAACAACTTATCGAAAAGCTAGCTCAAAATCGTATTGATGTAAAAACGTTCA
AACGTTTATCTGCTAGTTGTAAAAGTGAAGAGAATTACTCTACTTATTCAACCTACCAAATCGATGACAAATTAAAATAT
GTCATAAAAAATAAAATAACTTTACAGGATATAGCACCTTTTATCGATTGCATCAAAATAACTCAAACTAAACAATTACA
AGGAATCTACTTTAAAAACAGTCCACTCAATATCGTTGAACAATCACATTTAATAACTCCTGAAAGGAATGAAGTAATAT
GA
3D structure
| Source | ID | Structure |
|---|
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| ccrA | Staphylococcus aureus COL |
54.628 |
97.792 |
0.534 |
| ccrA | Staphylococcus aureus N315 |
50.564 |
97.792 |
0.494 |