Detailed information
Bioinformatically predicted
Overview
| Name | ccrA | Type | Machinery gene |
| Locus tag | KFV52_RS00460 | Genome accession | NZ_CP073835 |
| Coordinates | 63941..65302 (-) | Length | 453 a.a. |
| NCBI ID | WP_001631036.1 | Uniprot ID | - |
| Organism | Staphylococcus epidermidis strain B1230143 | ||
| Function | promote SCCmec transfer (predicted from homology) Homologous recombination |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| SCCmec | 62316..110977 | 63941..65302 | within | 0 |
Gene organization within MGE regions
Location: 62316..110977
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KFV52_RS00455 (KFV52_00455) | ccrB | 62316..63944 (-) | 1629 | WP_001631035.1 | recombinase family protein | Machinery gene |
| KFV52_RS00460 (KFV52_00460) | ccrA | 63941..65302 (-) | 1362 | WP_001631036.1 | recombinase family protein | Machinery gene |
| KFV52_RS00465 (KFV52_00465) | - | 65489..66118 (-) | 630 | Protein_54 | hypothetical protein | - |
| KFV52_RS00470 (KFV52_00470) | - | 66127..66465 (+) | 339 | Protein_55 | recombinase family protein | - |
| KFV52_RS00475 (KFV52_00475) | - | 66577..66936 (-) | 360 | WP_001631039.1 | hypothetical protein | - |
| KFV52_RS00480 (KFV52_00480) | - | 67143..67469 (+) | 327 | WP_000391495.1 | metalloregulator ArsR/SmtB family transcription factor | - |
| KFV52_RS00485 (KFV52_00485) | - | 67799..69724 (+) | 1926 | WP_002485723.1 | heavy metal translocating P-type ATPase | - |
| KFV52_RS00490 (KFV52_00490) | - | 70976..71281 (+) | 306 | WP_000677987.1 | hypothetical protein | - |
| KFV52_RS00495 (KFV52_00495) | - | 71479..72342 (+) | 864 | WP_000680579.1 | hypothetical protein | - |
| KFV52_RS00500 (KFV52_00500) | - | 72450..73925 (+) | 1476 | WP_001138664.1 | DUF6038 family protein | - |
| KFV52_RS00505 (KFV52_00505) | - | 74152..75252 (+) | 1101 | WP_000449985.1 | DNA polymerase | - |
| KFV52_RS00510 (KFV52_00510) | - | 75245..75616 (+) | 372 | WP_001058157.1 | hypothetical protein | - |
| KFV52_RS00515 (KFV52_00515) | - | 75613..77256 (+) | 1644 | WP_012086574.1 | DUF5906 domain-containing protein | - |
| KFV52_RS00520 (KFV52_00520) | - | 77483..79159 (+) | 1677 | WP_012086571.1 | recombinase family protein | - |
| KFV52_RS00525 (KFV52_00525) | - | 79265..79603 (+) | 339 | WP_012086569.1 | SAUGI family uracil-DNA glycosylase inhibitor | - |
| KFV52_RS00530 (KFV52_00530) | - | 79699..80010 (+) | 312 | WP_001083109.1 | DUF960 family protein | - |
| KFV52_RS00535 (KFV52_00535) | - | 80026..80532 (+) | 507 | WP_012086564.1 | DUF1643 domain-containing protein | - |
| KFV52_RS00540 (KFV52_00540) | - | 80560..81006 (+) | 447 | WP_012086562.1 | JAB domain-containing protein | - |
| KFV52_RS00545 (KFV52_00545) | - | 81176..82048 (+) | 873 | WP_012086560.1 | HTH domain-containing protein | - |
| KFV52_RS00550 (KFV52_00550) | - | 82100..82390 (+) | 291 | WP_012086558.1 | hypothetical protein | - |
| KFV52_RS00560 (KFV52_00560) | - | 82613..82768 (+) | 156 | Protein_72 | metal-sensing transcriptional repressor | - |
| KFV52_RS00565 (KFV52_00565) | - | 82765..83523 (+) | 759 | WP_000623679.1 | sulfite exporter TauE/SafE family protein | - |
| KFV52_RS00570 (KFV52_00570) | - | 83693..83902 (+) | 210 | Protein_74 | heavy metal translocating P-type ATPase | - |
| KFV52_RS00575 (KFV52_00575) | - | 83920..84465 (+) | 546 | WP_031869236.1 | YdhK family protein | - |
| KFV52_RS00580 (KFV52_00580) | - | 84908..86164 (+) | 1257 | WP_000566670.1 | DUF3578 domain-containing protein | - |
| KFV52_RS00585 (KFV52_00585) | - | 86609..87283 (-) | 675 | WP_001106057.1 | IS6-like element IS257 family transposase | - |
| KFV52_RS00590 (KFV52_00590) | - | 87367..87708 (+) | 342 | WP_001797647.1 | hydroxymethylglutaryl-CoA synthase | - |
| KFV52_RS00595 (KFV52_00595) | - | 88505..89248 (+) | 744 | WP_000958858.1 | glycerophosphoryl diester phosphodiesterase | - |
| KFV52_RS00600 (KFV52_00600) | - | 89345..89773 (+) | 429 | WP_000872606.1 | MaoC family dehydratase | - |
| KFV52_RS00605 (KFV52_00605) | mecA | 89819..91828 (-) | 2010 | WP_001801873.1 | PBP2a family beta-lactam-resistant peptidoglycan transpeptidase MecA | - |
| KFV52_RS00610 (KFV52_00610) | mecR1 | 91925..93682 (+) | 1758 | WP_000952923.1 | beta-lactam sensor/signal transducer MecR1 | - |
| KFV52_RS00615 (KFV52_00615) | mecI | 93682..94053 (+) | 372 | WP_000369214.1 | mecA-type methicillin resistance repressor MecI | - |
| KFV52_RS00620 (KFV52_00620) | psm-mec | 94138..94206 (-) | 69 | WP_014532405.1 | phenol-soluble modulin PSM-mec | - |
| KFV52_RS00625 (KFV52_00625) | - | 94561..95670 (+) | 1110 | WP_000943131.1 | ROK family transcriptional regulator | - |
| KFV52_RS00630 (KFV52_00630) | cstB | 95784..97118 (-) | 1335 | Protein_86 | persulfide dioxygenase-sulfurtransferase CstB | - |
| KFV52_RS00635 (KFV52_00635) | - | 97151..98215 (-) | 1065 | WP_000438836.1 | DsrE/DsrF/DrsH-like family protein | - |
| KFV52_RS00640 (KFV52_00640) | cstR | 98351..98611 (+) | 261 | WP_000220507.1 | persulfide-sensing transcriptional repressor CstR | - |
| KFV52_RS00645 (KFV52_00645) | - | 98611..99249 (+) | 639 | Protein_89 | sulfite exporter TauE/SafE family protein | - |
| KFV52_RS00655 (KFV52_00655) | - | 99523..100139 (-) | 617 | Protein_90 | CadD family cadmium resistance transporter | - |
| KFV52_RS00660 (KFV52_00660) | - | 100220..102634 (-) | 2415 | WP_000378485.1 | cadmium-translocating P-type ATPase CadA | - |
| KFV52_RS00665 (KFV52_00665) | - | 102627..102992 (-) | 366 | WP_000159127.1 | metalloregulator ArsR/SmtB family transcription factor | - |
| KFV52_RS00670 (KFV52_00670) | - | 103230..103607 (-) | 378 | WP_001041908.1 | DUF6262 family protein | - |
| KFV52_RS00675 (KFV52_00675) | - | 103614..105506 (-) | 1893 | WP_002485298.1 | site-specific integrase | - |
| KFV52_RS00680 (KFV52_00680) | - | 105701..106024 (-) | 324 | WP_000088091.1 | JAB domain-containing protein | - |
| KFV52_RS00685 (KFV52_00685) | - | 106017..106223 (-) | 207 | WP_001077283.1 | hypothetical protein | - |
| KFV52_RS00690 (KFV52_00690) | - | 106225..106746 (-) | 522 | WP_000836008.1 | DUF1643 domain-containing protein | - |
| KFV52_RS00695 (KFV52_00695) | - | 106765..107076 (-) | 312 | WP_000833212.1 | DUF960 family protein | - |
| KFV52_RS00700 (KFV52_00700) | - | 107161..107511 (-) | 351 | WP_000171449.1 | SAUGI family uracil-DNA glycosylase inhibitor | - |
| KFV52_RS00705 (KFV52_00705) | ccrB | 107982..109610 (-) | 1629 | WP_001186596.1 | recombinase family protein | Machinery gene |
| KFV52_RS00710 (KFV52_00710) | ccrA | 109631..110977 (-) | 1347 | WP_000816499.1 | recombinase family protein | Machinery gene |
Sequence
Protein
Download Length: 453 a.a. Molecular weight: 53316.45 Da Isoelectric Point: 9.8596
>NTDB_id=561155 KFV52_RS00460 WP_001631036.1 63941..65302(-) (ccrA) [Staphylococcus epidermidis strain B1230143]
MEEAIAYVRQSTLKQQSLATQKSLIMDTAKQYGWSNVAFYDDKKTGRHTKRSGYQKMVEIITSGKCKVLCCYRLNRLHRN
LKNAIQFFEICKKHHITIISVNDGYFDLSKEFDCFRLNILMSLAEMESNNISEQTKNGIREKAKQGKLITTHAPFGYRYR
KGCFVVQEEEAYTVKSVYRWYLQGLGYKKISQHLDSNPNLIPRKPYQVRNILLNPNYCGRVINKYGTFNDIVPPIIDIDT
FEEAQERRIHKQLNRSNSRNKLKRRIKCPYCQSTLTNLTIKKENYSLRYYVCPKNMNDAYRTCPFKSINAPELESEVLDT
CKKYFEEQSFHKRLNNTILKVLKQQQMKHKETHLTQEQLIEKLAQNRIDVKTFKRLSASCKSEENYSTYSTYQIDDKLKY
VIKNKITLQDIAPFIDCIKITQTKQLQGIYFKNSPLNIVEQSHLITPERNEVI
MEEAIAYVRQSTLKQQSLATQKSLIMDTAKQYGWSNVAFYDDKKTGRHTKRSGYQKMVEIITSGKCKVLCCYRLNRLHRN
LKNAIQFFEICKKHHITIISVNDGYFDLSKEFDCFRLNILMSLAEMESNNISEQTKNGIREKAKQGKLITTHAPFGYRYR
KGCFVVQEEEAYTVKSVYRWYLQGLGYKKISQHLDSNPNLIPRKPYQVRNILLNPNYCGRVINKYGTFNDIVPPIIDIDT
FEEAQERRIHKQLNRSNSRNKLKRRIKCPYCQSTLTNLTIKKENYSLRYYVCPKNMNDAYRTCPFKSINAPELESEVLDT
CKKYFEEQSFHKRLNNTILKVLKQQQMKHKETHLTQEQLIEKLAQNRIDVKTFKRLSASCKSEENYSTYSTYQIDDKLKY
VIKNKITLQDIAPFIDCIKITQTKQLQGIYFKNSPLNIVEQSHLITPERNEVI
Nucleotide
Download Length: 1362 bp
>NTDB_id=561155 KFV52_RS00460 WP_001631036.1 63941..65302(-) (ccrA) [Staphylococcus epidermidis strain B1230143]
ATGGAAGAAGCGATTGCTTATGTACGTCAAAGTACACTCAAACAACAAAGCTTAGCTACTCAAAAATCGCTCATTATGGA
TACCGCTAAGCAATATGGATGGTCTAATGTGGCGTTTTATGATGATAAGAAAACAGGTCGACATACAAAACGTTCAGGTT
ATCAAAAAATGGTAGAAATAATTACGTCTGGAAAATGTAAAGTATTGTGTTGCTATCGCTTGAACCGACTACATCGTAAT
TTGAAAAATGCCATACAATTCTTTGAAATTTGTAAAAAGCATCACATCACAATCATCAGTGTTAACGATGGATATTTTGA
TTTGTCTAAAGAGTTTGATTGCTTTCGTTTGAACATACTTATGAGTCTAGCGGAAATGGAATCAAACAATATCAGCGAAC
AAACAAAAAATGGGATTAGAGAAAAAGCCAAACAAGGTAAGCTAATCACAACTCATGCTCCGTTTGGCTATCGTTATAGA
AAAGGTTGTTTTGTTGTACAAGAAGAAGAAGCGTATACAGTTAAATCGGTTTATCGCTGGTACTTACAAGGTCTAGGCTA
CAAAAAGATTTCCCAACATTTGGATAGTAATCCTAACCTTATTCCTCGTAAGCCCTATCAAGTTAGAAATATTCTCTTGA
ACCCTAACTATTGCGGTCGTGTCATCAATAAATATGGCACGTTTAATGATATCGTTCCACCTATTATTGATATTGATACA
TTTGAAGAAGCACAAGAGCGTCGTATTCATAAACAACTCAATCGATCCAATTCTAGAAATAAGCTAAAGCGACGAATCAA
ATGTCCTTACTGTCAATCAACATTAACAAACTTAACGATAAAAAAAGAGAACTATTCTCTACGTTACTATGTTTGTCCTA
AAAATATGAATGACGCTTATCGTACATGCCCATTTAAAAGTATCAATGCACCAGAACTTGAAAGTGAAGTGCTCGACACT
TGTAAAAAGTATTTTGAAGAACAATCGTTTCATAAACGATTGAATAACACAATACTCAAAGTCCTAAAACAGCAACAAAT
GAAGCATAAAGAAACCCATCTAACACAAGAACAACTTATCGAAAAGCTAGCTCAAAATCGTATTGATGTAAAAACGTTCA
AACGTTTATCTGCTAGTTGTAAAAGTGAAGAGAATTACTCTACTTATTCAACCTACCAAATCGATGACAAATTAAAATAT
GTCATAAAAAATAAAATAACTTTACAGGATATAGCACCTTTTATCGATTGCATCAAAATAACTCAAACTAAACAATTACA
AGGAATCTACTTTAAAAACAGTCCACTCAATATCGTTGAACAATCACATTTAATAACTCCTGAAAGGAATGAAGTAATAT
GA
ATGGAAGAAGCGATTGCTTATGTACGTCAAAGTACACTCAAACAACAAAGCTTAGCTACTCAAAAATCGCTCATTATGGA
TACCGCTAAGCAATATGGATGGTCTAATGTGGCGTTTTATGATGATAAGAAAACAGGTCGACATACAAAACGTTCAGGTT
ATCAAAAAATGGTAGAAATAATTACGTCTGGAAAATGTAAAGTATTGTGTTGCTATCGCTTGAACCGACTACATCGTAAT
TTGAAAAATGCCATACAATTCTTTGAAATTTGTAAAAAGCATCACATCACAATCATCAGTGTTAACGATGGATATTTTGA
TTTGTCTAAAGAGTTTGATTGCTTTCGTTTGAACATACTTATGAGTCTAGCGGAAATGGAATCAAACAATATCAGCGAAC
AAACAAAAAATGGGATTAGAGAAAAAGCCAAACAAGGTAAGCTAATCACAACTCATGCTCCGTTTGGCTATCGTTATAGA
AAAGGTTGTTTTGTTGTACAAGAAGAAGAAGCGTATACAGTTAAATCGGTTTATCGCTGGTACTTACAAGGTCTAGGCTA
CAAAAAGATTTCCCAACATTTGGATAGTAATCCTAACCTTATTCCTCGTAAGCCCTATCAAGTTAGAAATATTCTCTTGA
ACCCTAACTATTGCGGTCGTGTCATCAATAAATATGGCACGTTTAATGATATCGTTCCACCTATTATTGATATTGATACA
TTTGAAGAAGCACAAGAGCGTCGTATTCATAAACAACTCAATCGATCCAATTCTAGAAATAAGCTAAAGCGACGAATCAA
ATGTCCTTACTGTCAATCAACATTAACAAACTTAACGATAAAAAAAGAGAACTATTCTCTACGTTACTATGTTTGTCCTA
AAAATATGAATGACGCTTATCGTACATGCCCATTTAAAAGTATCAATGCACCAGAACTTGAAAGTGAAGTGCTCGACACT
TGTAAAAAGTATTTTGAAGAACAATCGTTTCATAAACGATTGAATAACACAATACTCAAAGTCCTAAAACAGCAACAAAT
GAAGCATAAAGAAACCCATCTAACACAAGAACAACTTATCGAAAAGCTAGCTCAAAATCGTATTGATGTAAAAACGTTCA
AACGTTTATCTGCTAGTTGTAAAAGTGAAGAGAATTACTCTACTTATTCAACCTACCAAATCGATGACAAATTAAAATAT
GTCATAAAAAATAAAATAACTTTACAGGATATAGCACCTTTTATCGATTGCATCAAAATAACTCAAACTAAACAATTACA
AGGAATCTACTTTAAAAACAGTCCACTCAATATCGTTGAACAATCACATTTAATAACTCCTGAAAGGAATGAAGTAATAT
GA
3D structure
| Source | ID | Structure |
|---|
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| ccrA | Staphylococcus aureus COL |
54.628 |
97.792 |
0.534 |
| ccrA | Staphylococcus aureus N315 |
50.564 |
97.792 |
0.494 |