Detailed information NTG0561009

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: KFV43_RS04900
• Genome accession: NZ_CP073821
• Coordinates: 946541..947587 (+)
• Length: 348 a.a.
• NCBI ID: WP_001830374.1
• Uniprot ID: A0A0N1EGU4
• Organism: Staphylococcus epidermidis strain B1200343
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 941541..952587

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
KFV43_RS04875 (KFV43_04875)	-	942682..943218 (+)	537	WP_002470337.1	hypothetical protein	-
KFV43_RS04880 (KFV43_04880)	-	943369..944355 (-)	987	WP_001830388.1	aromatic acid exporter family protein	-
KFV43_RS04885 (KFV43_04885)	map	944529..945284 (+)	756	WP_002457092.1	type I methionyl aminopeptidase	-
KFV43_RS04890 (KFV43_04890)	-	945442..945828 (+)	387	WP_001830382.1	hypothetical protein	-
KFV43_RS04895 (KFV43_04895)	liaF	945843..946544 (+)	702	WP_001830436.1	cell wall-active antibiotics response protein LiaF	-
KFV43_RS04900 (KFV43_04900)	vraS	946541..947587 (+)	1047	WP_001830374.1	sensor histidine kinase	Regulator
KFV43_RS04905 (KFV43_04905)	vraR	947577..948206 (+)	630	WP_001830439.1	two-component system response regulator VraR	Regulator
KFV43_RS04910 (KFV43_04910)	-	948263..949441 (-)	1179	WP_001830411.1	YihY/virulence factor BrkB family protein	-
KFV43_RS04915 (KFV43_04915)	-	949848..950132 (-)	285	WP_001830401.1	YtxH domain-containing protein	-
KFV43_RS04920 (KFV43_04920)	-	950140..950604 (-)	465	WP_001830437.1	low molecular weight protein-tyrosine-phosphatase	-
KFV43_RS04925 (KFV43_04925)	-	950745..950960 (+)	216	WP_001830421.1	DUF1128 domain-containing protein	-
KFV43_RS04930 (KFV43_04930)	-	950962..952203 (+)	1242	WP_001832467.1	aminopeptidase	-

Sequence

Protein

• Length: 348 a.a.
• Molecular weight: 40066.49 Da
• Isoelectric Point: 5.8512

>NTDB_id=561009 KFV43_RS04900 WP_001830374.1 946541..947587(+) (vraS) [Staphylococcus epidermidis strain B1200343]
MNHYIRAIGSMLILVYSMLIAFLFIDKVFVNIIFFQGMFYTQIFGIPVFLFLNLLIVLLCIIVGSVLAYKINQQNDWIIS
QIERSIEGQTVGINDQNIELYTETIDIYHTLVPLNQELHRLRMKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKESKLEPPLNQQIPILEKMVQDSQLEMRALLLHLRPIGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFEVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNQEDYLLLRIQDNGKGFNVDEKFEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEENSSGD

Nucleotide

• Length: 1047 bp

>NTDB_id=561009 KFV43_RS04900 WP_001830374.1 946541..947587(+) (vraS) [Staphylococcus epidermidis strain B1200343]
ATGAATCACTACATAAGAGCTATAGGCTCAATGCTTATATTAGTATATAGTATGCTTATTGCTTTTTTATTTATTGATAA
AGTGTTTGTAAATATTATCTTTTTTCAGGGGATGTTTTATACACAAATATTTGGAATACCTGTTTTTCTATTTTTAAATT
TATTAATTGTTCTTTTATGTATTATAGTTGGATCTGTTTTAGCTTATAAAATTAATCAACAAAATGATTGGATTATTTCA
CAAATAGAAAGATCAATAGAAGGACAAACAGTAGGTATCAATGATCAAAATATCGAATTATATACAGAAACGATAGATAT
TTATCATACACTAGTTCCATTAAATCAAGAATTACATCGACTTAGAATGAAGACTCAAAATTTAACTAATGAAAACTACA
ATATTAATGATGTAAAAGTCAAAAAGATTATCGAAGATGAGCGACAACGACTTGCCAGGGAATTACATGATTCTGTTAGT
CAACAATTATTTGCTGCGAGCATGATGCTATCGGCGATAAAAGAGTCGAAATTAGAACCACCTTTAAATCAACAGATACC
AATTCTTGAAAAAATGGTTCAAGACTCACAACTTGAAATGAGAGCTTTGTTATTACATTTAAGACCGATAGGTTTAAAAG
ATAAGTCTTTAGGTGAAGGAATTAAAGATTTAGTCATCGATTTACAAAAGAAAGTACCAATGAAAGTTGTGCATGAAATT
CAAGATTTTGAAGTGCCAAAAGGCATTGAAGATCACTTGTTCAGAATTACACAAGAAGCTATTTCAAATACATTGAGACA
TTCAAATGGTACAAAAGTAACTGTGGAATTATTTAATCAAGAGGATTATCTTTTACTAAGAATTCAAGATAATGGAAAAG
GGTTTAATGTAGATGAAAAATTTGAACAAAGTTATGGTTTGAAAAATATGCGAGAACGAGCGTTAGAAATTGGTGCGACG
TTTCATATTGTATCTTTACCTGATTCAGGTACACGAATTGAAGTTAAGGCACCATTGAATAAGGAGGAGAATTCAAGTGG
CGATTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0N1EGU4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	93.023	98.851	0.92