Detailed information    

insolico Bioinformatically predicted

Overview

Name   clpE   Type   Regulator
Locus tag   INT76_RS03780 Genome accession   NZ_CP073084
Coordinates   755470..757710 (+) Length   746 a.a.
NCBI ID   WP_212572347.1    Uniprot ID   -
Organism   Streptococcus oriscaviae strain HKU75     
Function   degradation of ComX (predicted from homology)   
Competence regulation

Genomic Context

Location: 750470..762710
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  INT76_RS03750 (INT76_03750) - 750747..751595 (-) 849 WP_212572335.1 bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase -
  INT76_RS03755 (INT76_03755) - 751703..752437 (-) 735 WP_212572337.1 amino acid ABC transporter ATP-binding protein -
  INT76_RS03760 (INT76_03760) - 752430..753119 (-) 690 WP_212572339.1 amino acid ABC transporter permease -
  INT76_RS03765 (INT76_03765) - 753277..753507 (-) 231 WP_212572341.1 DUF1797 family protein -
  INT76_RS03770 (INT76_03770) - 753682..754986 (+) 1305 WP_212572343.1 DUF1576 domain-containing protein -
  INT76_RS03775 (INT76_03775) - 754967..755308 (+) 342 WP_212572345.1 hypothetical protein -
  INT76_RS03780 (INT76_03780) clpE 755470..757710 (+) 2241 WP_212572347.1 ATP-dependent Clp protease ATP-binding subunit Regulator
  INT76_RS03785 (INT76_03785) - 757766..758032 (+) 267 WP_212572353.1 hypothetical protein -
  INT76_RS03790 (INT76_03790) - 758130..759125 (-) 996 WP_212572355.1 MBL fold metallo-hydrolase -
  INT76_RS03795 (INT76_03795) - 759299..759757 (+) 459 WP_212572357.1 NUDIX hydrolase -
  INT76_RS03800 (INT76_03800) - 759808..760119 (+) 312 WP_212572359.1 DUF1827 family protein -

Sequence

Protein


Download         Length: 746 a.a.        Molecular weight: 82645.08 Da        Isoelectric Point: 5.4393

>NTDB_id=557831 INT76_RS03780 WP_212572347.1 755470..757710(+) (clpE) [Streptococcus oriscaviae strain HKU75]
MLCHNCKINDATIHLYTNLNGKQQQVDLCHNCYQIMKTDPNNAILKGLGDLSNPNNMDPFSEFFNNLGGYPGKTPAGKPR
NPTPPTQSGGGNGRNNGGNQQPPQRPNGLLEEFGINVTEIARRGEIDPVIGRDQEITRVIEILNRRTKNNPVLIGEPGVG
KTAVVEGLAQKIVDGAVPQKLQGKEVIRLDVVSLVQGTGIRGQFEERMQKLMEEIRNRKEVILFIDEIHEIVGAGSAGDG
NMDAGNILKPALARGEMQLVGATTLNEYRIIEKDAALERRMQPVKVDEPSVEETITILKGIQSKYQDYHHVKYTDAAIEA
AAVLSNRYIQDRFLPDKAIDLLDEAGSKMNLTLNFVDPKELDQRLIDAENRKAQATRDEDYEKAAYFRDQIAKYKEMQKA
TLSEEDTPLITEKEIEAIVEQKTNIPVGDLKEKEQSQLINLASDLKAHVIGQDQAVDKIAKAIRRNRVGLGAPNRPIGSF
LFVGPTGVGKTELSKQLAIELFGSADSMIRFDMSEYMEKHAVAKLVGAPPGYVGYEEAGQLTEKVRRNPYSLILLDEVEK
AHPDVMHMFLQVLDDGRLTDGQGRTVSFKDTIIIMTSNAGTGKVEASVGFGAAMEGRSQSVLGQLSNFFSPEFMNRFDGI
IEFQPLSKENLLQIVDLMLQDVNKRLASNGISLHVTDKVKEKLVDLGYDPKMGARPLRRTIQDQIEDAVTDFYLEHPNEK
DLRAVMNAKGEILVKASQKKPVETSA

Nucleotide


Download         Length: 2241 bp        

>NTDB_id=557831 INT76_RS03780 WP_212572347.1 755470..757710(+) (clpE) [Streptococcus oriscaviae strain HKU75]
ATGCTTTGTCACAATTGTAAAATCAACGATGCAACTATTCACCTTTACACCAATCTCAACGGAAAACAGCAACAAGTCGA
CCTCTGTCATAACTGCTATCAAATCATGAAGACCGACCCTAACAATGCCATTTTAAAAGGCTTGGGCGATTTGTCCAATC
CAAACAATATGGATCCTTTTAGTGAGTTTTTCAATAATTTGGGAGGCTATCCTGGAAAAACACCTGCTGGCAAGCCCCGC
AACCCGACTCCACCCACCCAGTCAGGAGGAGGAAACGGCCGCAATAATGGAGGAAATCAACAACCGCCGCAGCGTCCAAA
TGGTCTTTTGGAAGAGTTTGGCATAAACGTTACCGAAATTGCCCGCCGAGGCGAAATAGACCCTGTTATCGGTCGCGATC
AGGAAATCACCCGTGTCATTGAAATTCTCAACCGCAGAACCAAGAACAATCCTGTTCTTATCGGCGAACCCGGAGTTGGT
AAAACAGCTGTTGTCGAAGGACTAGCCCAGAAGATTGTCGATGGAGCTGTTCCGCAAAAACTACAAGGGAAGGAAGTTAT
CCGACTGGATGTAGTCAGCTTGGTACAAGGAACTGGAATCCGCGGTCAATTTGAAGAACGAATGCAAAAGCTGATGGAAG
AGATTCGCAACCGCAAGGAAGTCATTCTCTTTATTGACGAGATTCATGAGATTGTCGGAGCAGGTTCTGCAGGTGATGGC
AATATGGATGCGGGAAATATCCTCAAACCAGCCCTAGCACGTGGAGAAATGCAGCTAGTCGGTGCTACCACTCTCAATGA
GTATCGCATCATTGAAAAAGATGCCGCTCTGGAACGTCGGATGCAGCCTGTCAAGGTAGATGAACCAAGTGTAGAAGAAA
CCATCACCATCCTCAAGGGTATCCAAAGCAAGTACCAAGACTATCACCATGTCAAGTACACCGATGCTGCTATTGAAGCT
GCTGCCGTTCTTTCCAACCGCTACATTCAGGATCGTTTCTTGCCAGATAAGGCCATTGACCTATTGGATGAAGCAGGCTC
TAAGATGAATCTGACCCTCAACTTTGTCGATCCAAAAGAACTGGACCAACGCCTGATTGATGCTGAGAATCGCAAGGCTC
AGGCAACCCGAGATGAAGATTATGAAAAAGCTGCTTATTTCCGTGACCAAATTGCCAAATACAAGGAAATGCAAAAAGCA
ACCTTGAGCGAAGAAGATACCCCGCTCATCACCGAGAAGGAAATTGAAGCCATTGTAGAGCAAAAGACCAATATCCCTGT
CGGTGACCTTAAAGAAAAAGAACAGTCACAGCTAATCAATCTAGCTAGCGACCTCAAGGCTCATGTCATCGGTCAAGATC
AGGCAGTCGATAAGATTGCTAAGGCCATCCGCCGTAACCGTGTCGGTCTTGGTGCCCCTAATCGCCCTATCGGCAGCTTC
CTCTTTGTGGGGCCAACGGGTGTCGGAAAGACCGAGCTTTCCAAACAACTGGCCATTGAACTCTTTGGTTCAGCAGATAG
TATGATTCGCTTCGATATGTCTGAGTATATGGAAAAACACGCAGTGGCTAAACTGGTTGGAGCCCCTCCAGGCTACGTTG
GCTACGAAGAAGCTGGTCAGCTGACAGAAAAAGTCCGTCGCAACCCTTACTCTCTCATCCTTCTTGATGAGGTTGAAAAG
GCACATCCGGACGTCATGCATATGTTCTTACAAGTTCTGGATGACGGCCGACTAACAGATGGTCAAGGCCGTACCGTCAG
CTTCAAAGACACCATTATTATCATGACTTCCAATGCTGGAACAGGTAAGGTGGAGGCTAGTGTTGGTTTTGGAGCGGCTA
TGGAAGGCCGGAGCCAATCTGTTCTTGGCCAACTCAGCAATTTCTTTAGTCCTGAATTCATGAACCGCTTTGATGGTATT
ATCGAATTTCAACCGCTCAGCAAGGAAAATCTCCTGCAAATCGTTGATCTCATGCTGCAAGATGTCAATAAACGTCTAGC
AAGCAACGGTATCAGCCTGCATGTGACCGACAAGGTTAAGGAAAAACTGGTCGACTTGGGCTACGATCCAAAGATGGGAG
CTCGTCCTCTTCGTCGAACCATTCAGGATCAAATCGAAGATGCCGTCACAGACTTCTATCTGGAGCATCCAAACGAAAAA
GACCTTCGGGCTGTGATGAATGCCAAAGGGGAAATCCTTGTCAAAGCCAGCCAGAAAAAACCGGTCGAAACCAGTGCATA
A

Domains

Predicted by InterProScan.

ATPase family associated with various cellular activities (AAA) (AAA)

(152-271)

AAA lid domain (AAA_lid_9)

(290-388)

AAA domain (Cdc48 subfamily) (AAA_2)

(475-638)

C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small)

(646-717)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  clpE Streptococcus pneumoniae Rx1

82.736

100

0.835
  clpE Streptococcus pneumoniae D39

82.736

100

0.835
  clpE Streptococcus pneumoniae R6

82.736

100

0.835
  clpE Streptococcus pneumoniae TIGR4

82.736

100

0.835
  clpE Streptococcus mutans UA159

82.603

100

0.834
  clpC Lactococcus lactis subsp. cremoris KW2

77.931

97.185

0.757
  clpC Bacillus subtilis subsp. subtilis str. 168

49.857

93.566

0.466
  clpC Lactococcus lactis subsp. lactis strain DGCC12653

46.789

87.668

0.41
  clpC Streptococcus thermophilus LMD-9

47.95

84.987

0.408
  clpC Streptococcus mutans UA159

48.32

83.78

0.405
  clpC Streptococcus thermophilus LMG 18311

47.634

84.987

0.405
  clpC Streptococcus pneumoniae Rx1

48.16

83.78

0.403
  clpC Streptococcus pneumoniae D39

48.16

83.78

0.403
  clpC Streptococcus pneumoniae TIGR4

48

83.78

0.402